European Journal of Chemistry 2019, 10(4), 273-280 | doi: https://doi.org/10.5155/eurjchem.10.4.273-280.1885 | Get rights and content






  OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms


Mohamed Salem Rizk (1) orcid , Emad Mohamed Hussien (2) orcid , Rasha Tharwat El-Eryan (3) orcid , Amira Mohamed Daoud (4,*) orcid

(1) Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(2) National Organization for Drug Control & Research (NODCAR), Cairo, 29, Egypt
(3) Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt
(4) National Organization for Drug Control & Research (NODCAR), Cairo, 29, Egypt
(*) Corresponding Author

Received: 27 Apr 2019 | Revised: 12 Jun 2019 | Accepted: 30 Jul 2019 | Published: 31 Dec 2019 | Issue Date: December 2019

Abstract


All-solid state potentiometric ion selective electrodes have the merits of being portable, small and suitable for small volume samples. Herein, disposable home-made screen printed polymeric ion selective electrode (SPE) is developed for determination of oxymetazoline (OXM) in pharmaceutical nasal drops and drug substance. Ion selective electrodes with optimal potentiometric response were achieved by careful selection of the ion exchanger and plasticizer. A screen printed electrode utilizing oxymetazoline-tetraphenyl borate (OXM-TPB) as an ion exchanger and dibutyl phthalate (DBP) as a plasticizer exhibited a Nernstian slope of 59.5±0.5 mV/decade (n=3) over the concentration range from 1×10-5 to 1×10-2 M OXM (r = 0.9999) with a detection limit of 5.0×10-6 M. The electrode is useful over a wide pH range from 4.0 to 8.0. The electrode showed a high selectivity for OXM against several common interfering ions. The potential interference from benzalkonium chloride was easily eliminated by treatment the sample with KI. Comparable potentiometric characteristics including linearity, detection limit, pH range and selectivity pattern were obtained with a carbon paste electrode (CPE) comprising same ion exchanger and plasticizer. The electrodes were successfully used for the assay of OXM in the drug substance and in the dosage form in presence of benzalkonium chloride with high accuracy (±2%) and precision (%RSD ˂2.5). The proposed method is simple, accurate and precise.


Keywords


Electrode; Solid-state; Carbon paste; Screen printing; Oxymetazoline HCl; Ion selective electrode

Full Text:

PDF /    /


DOI: 10.5155/eurjchem.10.4.273-280.1885

Links for Article


| | | | |

| | | | | | |

Related Articles




Article Metrics

This Abstract was viewed 137 times | PDF Article downloaded 37 times


References

[1]. The United States Pharmacopeia (USP), USP 39-NF 34 (2016), Rockville, MD, USA.

[2]. Martindale: The complete drug reference, Thirty-six edition, Royal Pharmaceutical Society of Great Britain, RPS, 2009.

[3]. Covington, T. R.; Pau, A. K. American Pharm. 1985, 25, 21-26.
https://doi.org/10.1016/S0160-3450(16)32692-7

[4]. Theia'a, N.; Mohammed, N. M.; Abdul-Jabar, P. A. Eur. Chem. Bull. 2015, 4, 372-377.

[5]. Abdel-Aziz, O.; El-Kosasy, A.; Magdy, N.; El Zahar, N. Spectrochim. Acta A 2014, 131, 59-66.
https://doi.org/10.1016/j.saa.2014.04.047

[6]. Othman, N. S.; Fathe, S. A. Rafidain J. Sci. 2013, 24, 84-95.

[7]. Al-Sabha, T. A. N.; Rasheed, B. A. Jordan J. Chem. 2011, 146, 1-9.

[8]. Palma, R. J.; Palkowetz, J. M. Anal. Lett. B, Clin. Biochem. Anal. 1981, 14, 357-362.
https://doi.org/10.1080/00032718108081411

[9]. Hoffmann, T. J.; Thompson, R. D.; Seifert, J. R. Drug Develop. Indus. Pharm. 1989, 15, 743-757.
https://doi.org/10.3109/03639048909058529

[10]. Hayes, F. J.; Baker, T. R.; Dobson, R. L. M.; Tsueda, M. S. J. Chromatog. A 1995, 692, 73-81.
https://doi.org/10.1016/0021-9673(94)00630-R

[11]. Sudsakorn, S.; Kaplan, L.; Williams, D. A. J. Pharm. Biomed. Anal. 2006, 40, 1273-1280.
https://doi.org/10.1016/j.jpba.2005.09.018

[12]. Golubitskii, G. B.; Basova, E. M.; Ivanov, V. M. J. Anal. Chem. 2008, 63, 875-880.
https://doi.org/10.1134/S1061934808090141

[13]. Garcia-Campana, A. M.; Sendra, J. M. B.; Vargas, M. P. B.; Baeyens, W. R. G.; Zhang, X. R. Anal. Chim. Acta 2004, 516, 245-249.
https://doi.org/10.1016/j.aca.2004.03.067

[14]. Wang, N. N.; Sha, Y. Q.; Tang, Y. H.; Yin, H. P.; Wu, X. Z. Luminescence 2009, 24, 178-182.
https://doi.org/10.1002/bio.1092

[15]. Issa, Y. M.; Zayed, S. I. M. Anal. Sci. 2004, 20, 297-300.
https://doi.org/10.2116/analsci.20.297

[16]. Derar, A. R.; Hussien, E. M. IEEE Sensors J. 2019, 19, 1626-1632.
https://doi.org/10.1109/JSEN.2018.2883656

[17]. Hussien, E. M.; Derar, A. R. SN Appl. Sci. 2019, 1, 338, 1-11.
https://doi.org/10.1007/s42452-019-0349-z

[18]. Tymecki, L.; Glab, S.; Koncki, R. Sensors 2006, 6, 390-396.
https://doi.org/10.3390/s6040390

[19]. Trojanowicz, M. Trac-Trends Anal. Chem. 2016, 84, 22-47.
https://doi.org/10.1016/j.trac.2016.03.027

[20]. Buck, R. P.; Linder, E. Pure Appl. Chem. 1994, 66, 2527-2536.
https://doi.org/10.1351/pac199466122527

[21]. Bakker, E.; Pretsch, E.; Bühlmann, P. Anal. Chem. 2000, 72, 1127-1133.
https://doi.org/10.1021/ac991146n

[22]. ICH Guidelines, In Validation of analytical procedures: text and methodology Q2 (R1), International conference on harmonization, Geneva, Switzerland, 2005; pp 11-12.

How to cite


Rizk, M.; Hussien, E.; El-Eryan, R.; Daoud, A. Eur. J. Chem. 2019, 10(4), 273-280. doi:10.5155/eurjchem.10.4.273-280.1885
Rizk, M.; Hussien, E.; El-Eryan, R.; Daoud, A. All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms. Eur. J. Chem. 2019, 10(4), 273-280. doi:10.5155/eurjchem.10.4.273-280.1885
Rizk, M., Hussien, E., El-Eryan, R., & Daoud, A. (2019). All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms. European Journal of Chemistry, 10(4), 273-280. doi:10.5155/eurjchem.10.4.273-280.1885
Rizk, Mohamed, Emad Mohamed Hussien, Rasha Tharwat El-Eryan, & Amira Mohamed Daoud. "All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms." European Journal of Chemistry [Online], 10.4 (2019): 273-280. Web. 20 Jan. 2020
Rizk, Mohamed, Hussien, Emad, El-Eryan, Rasha, AND Daoud, Amira. "All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms" European Journal of Chemistry [Online], Volume 10 Number 4 (31 December 2019)

DOI Link: https://doi.org/10.5155/eurjchem.10.4.273-280.1885

| | | | |

| | | | | |

Save to Zotero Save to Mendeley

European Journal of Chemistry 2019, 10(4), 273-280 | doi: https://doi.org/10.5155/eurjchem.10.4.273-280.1885 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c) 2019 Authors

Creative Commons License
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).


© Copyright 2019  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.