

Synthesis of new 3,4-dihydropyrano[c]chromene derivatives and their evaluation as acetyl cholinesterase inhibitors
Younes Bouazizi (1)



(1) Chemistry Department, Faculty of Science, Jazan University, 2097, Saudi Arabia
(2) Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Bioorganic Chemistry and Natural Products, Faculty of Sciences, University of Monastir, Monastir, 5000, Tunisia
(3) Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Bioorganic Chemistry and Natural Products, Faculty of Sciences, University of Monastir, Monastir, 5000, Tunisia
(*) Corresponding Author
Received: 02 Mar 2014 | Accepted: 27 Apr 2014 | Published: 30 Sep 2014 | Issue Date: September 2014
Abstract
2-Amino-4-phenyl-4,5-dihydro-5-oxopyrano[2,3-c]chromen-3-carbonitrile derivatives (8a-d) have been isolated in good yields by the reaction of corresponding 4-hydroxycoumarin (1) with substituted aldehydes (2a-d) and malononitrile (3) under reflux conditions. The reactivity of α-functionalized iminoethers (9a-d) with hydrazine, hydroxylamine and piperidine was studied. The synthesized compounds were characterized by various techniques including spectroscopy. Compounds 8-11 were also evaluated as potential acetylcholinesterase inhibitors.
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DOI: 10.5155/eurjchem.5.3.457-462.1040
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Citations
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Synthesis, characterization and DFT studies of diethyl 4-hydroxy-6-nitro-4H-chromene-2,3-dicarboxylate
Journal of Molecular Structure 1105, 118, 2016
DOI: 10.1016/j.molstruc.2015.10.044

[2]. Maher Cherif, Mabrouk Horchani, Youssef O. Al-Ghamdi, Sami G. Almalki, Yaser E. Alqurashi, Hichem Ben Jannet, Anis Romdhane
New pyrano-1,2,3-triazolopyrimidinone derivatives as anticholinesterase and antibacterial agents: Design, microwave-assisted synthesis and molecular docking study
Journal of Molecular Structure 1220, 128685, 2020
DOI: 10.1016/j.molstruc.2020.128685

[3]. Soraya Rahmatinejad, Hossein Naeimi
Design, preparation, and characterization of Fe3O4 nanoparticles encapsulating β‐cyclodextrin‐bearing guanidine as a highly efficient and reusable heterogeneous base catalyst for synthesis of 3,4‐dihydropyrano[3,2‐c]chromenes
Applied Organometallic Chemistry 34(10), , 2020
DOI: 10.1002/aoc.5862

[4]. Najet Aouled Dlala, Younes Bouazizi, Houcine Ghalla, Naceur Hamdi, Pasquale Longo
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[5]. Pooja Garg, Sabbasani Rajasekhara Reddy
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[6]. Arezou Mohammadinezhad, Batool Akhlaghinia
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DOI: 10.1071/CH17093

[7]. Amel Hajlaoui, Maha Laajimi, Mansour Znati, Hichem Ben Jannet, Anis Romdhane
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DOI Link: https://doi.org/10.5155/eurjchem.5.3.457-462.1040

















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