European Journal of Chemistry

Synthesis of new 3,4-dihydropyrano[c]chromene derivatives and their evaluation as acetyl cholinesterase inhibitors



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Younes Bouazizi
Anis Romdhane
Hichem Ben Jannet

Abstract

2-Amino-4-phenyl-4,5-dihydro-5-oxopyrano[2,3-c]chromen-3-carbonitrile derivatives (8a-d) have been isolated in good yields by the reaction of corresponding 4-hydroxycoumarin (1) with substituted aldehydes (2a-d) and malononitrile (3) under reflux conditions. The reactivity of α-functionalized iminoethers (9a-d) with hydrazine, hydroxylamine and piperidine was studied. The synthesized compounds were characterized by various techniques including spectroscopy. Compounds 8-11 were also evaluated as potential acetylcholinesterase inhibitors.


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Bouazizi, Y.; Romdhane, A.; Jannet, H. B. Synthesis of New 3,4-dihydropyrano[c]chromene Derivatives and Their Evaluation As Acetyl Cholinesterase Inhibitors. Eur. J. Chem. 2014, 5, 457-462.

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