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Synthesis of 2-aryl substituted 2,3-dihydroquinazoline-4(1H)-ones under solvent free conditions using ionic liquid as a mild and efficient catalyst
Obaiah Obaiah (1)
, Nandeesh Nagalingaiah Kebbahalli (2) , Raghavendra Manchigaiah Goravanahalli (3) , Pavankumar Siddalingaiah Chottanahalli (4) , Rangappa Subbegowda Kanchugarakoppal (5) , Mantelingu Kempegowda (6,*) (1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(5) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(6) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570006, India
(*) Corresponding Author
Received: 10 Apr 2014 | Revised: 14 May 2014 | Accepted: 13 Jun 2014 | Published: 31 Dec 2014 | Issue Date: December 2014
Abstract
A simple, green and environmentally benign procedure has been developed for the synthesis of 2,3-dihydroquinazoline-4(1H)-ones in basic ionic liquid via the cyclocondensation of 2-amino benzamide with an aldehyde. This offers several advantages such as high yields, simple procedure, low cost, short reaction times, mild and solvent free condition.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.5.4.671-675.1071
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Funding information
University Grants Commission, Government of India, The project vide No. F. No. 39-710-2011 (SR/dated 12-01-2010).
Citations
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Schiff base ligands derived from 4-chloro-6-methylpyrimidin-2-amine: Chemical synthesis, bactericidal activity and molecular docking studies against targeted microbial pathogen
International Journal of Health & Allied Sciences 10(2), 157, 2021
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[3]. Archana Rajmane, Dipti Jadhav, Kiran Bagade, Suresh Patil, Arjun Kumbhar
Alginic acid in water at room temperature: a natural combination for the environmental benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Research on Chemical Intermediates 49(12), 5237, 2023
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[4]. Satish Uttamrao Deshmukh, Kiran Ramesh Kharat, Gajanan Gulabrao Kadam, Rajendra Pundlikrao Pawar
Synthesis of quinazolinones derivatives an antiproliferative agent against human lung carcinoma cells
European Journal of Chemistry 8(3), 317, 2017
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[5]. Jie Mou, Ninghai Chen, Yu Zhao, Hao Qi, Sihan Meng, Rui Xiang, Dongsheng Pei
An Aqueous Facile Synthesis of 2,3-Dihydroquinazolin-4(1H)-One Derivatives by Reverse Zinc Oxide Micelles as Nanoreactor
Frontiers in Chemistry 8, , 2020
DOI: 10.3389/fchem.2020.00239
[6]. Madiha M. Siddiqui, Amol A. Nagargoje, Satish V. Akolkar, Jaiprakash N. Sangshetti, Vijay M. Khedkar, Parshuram M. Pisal, Bapurao B. Shingate
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Research on Chemical Intermediates 48(3), 1199, 2022
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[7]. Mariateresa Badolato, Francesca Aiello, Nouri Neamati
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[8]. Sadashivamurthy Shamanth, Nagaraju Chaithra, Mahesha Gurukiran, Mahesha Mamatha, N. K. Lokanath, Kanchugarakoppal S. Rangappa, Kempegowda Mantelingu
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Ultrasound-promoted Regioselective Synthesis of 2-aryl-quinazolinones Using Citric Acid as a Natural and Efficient Media and Catalyst
Letters in Organic Chemistry 20(8), 763, 2023
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KOH/DMSO: A basic suspension for transition metal-free Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones
Tetrahedron Letters 60(24), 1614, 2019
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