A convenient synthesis and preparation of the derivatives of  ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents

Shawkat Ahmed Abdelmohsen

doi:10.5155/eurjchem.5.3.517-525.1072

European Journal of Chemistry 2014, 5(3), 517-525 | doi: https://doi.org/10.5155/eurjchem.5.3.517-525.1072 | Get rights and content

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A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents

Shawkat Ahmed Abdelmohsen ^(1,*)

⁽¹⁾ Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt
^(*) Corresponding Author

Received: 10 Apr 2014 | Revised: 29 May 2014 | Accepted: 06 Jun 2014 | Published: 30 Sep 2014 | Issue Date: September 2014

Abstract

Synthesis of ethyl 6-(8-hydroxyquinolin-5-yl)-3-methylpyridazin-4-carboxylate (4) via one-pot three component reaction of ethyl acetoacetate with (8-hydroxyquinolin-5-yl)(oxo) acetaldehyde (2) in the presence of hydrazine hydrate at room temperature in water was described. A new series of heterocyclic moieties such as oxadiazoles, triazoles, pyrazoles and Schiff bases were prepared and characterized. The structures of the newly synthesized compounds were established by elemental and spectral data. The antimicrobial activity of some of the synthesized compounds was examined against two Gram‐positive bacteria, two Gram‐negative bacteria and four fungi. The results showed that the tested compounds exhibited significant to moderate antimicrobial.

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Keywords

Triazoles; Pyrazoles; Pyridazines; Oxadiazoles; One-pot reaction; Antimicrobial activity

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DOI: 10.5155/eurjchem.5.3.517-525.1072

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Citations

[1]. Shawkat Ahmed Abdelmohsen, Yasser Abou-bakr El-Ossaily
One-pot synthesis of 5-[1-substituted 4-acetyl-5-methyl-1H-pyrrol-2-yl)]-8-hydroxyquinolines using DABCO as green catalyst
Heterocyclic Communications 21(4), 207, 2015
DOI: 10.1515/hc-2015-0033

[2]. A. V. Velikorodov, E. A. Shustova
Synthesis and some transformations of methyl [4-(oxoacetyl)phenyl]carbamate
Russian Journal of Organic Chemistry 53(1), 82, 2017
DOI: 10.1134/S1070428017010146

[3]. Oszkár Csuvik, István Szatmári
Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction
International Journal of Molecular Sciences 24(9), 7915, 2023
DOI: 10.3390/ijms24097915

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How to cite

Abdelmohsen, S. Eur. J. Chem. 2014, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072

Abdelmohsen, S. A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents. Eur. J. Chem. 2014, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072

Abdelmohsen, S. (2014). A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents. European Journal of Chemistry, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072

Abdelmohsen, Shawkat. "A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents." European Journal of Chemistry [Online], 5.3 (2014): 517-525. Web. 3 Jun. 2023

Abdelmohsen, Shawkat. "A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

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