European Journal of Chemistry 2014, 5(3), 517-525 | doi: https://doi.org/10.5155/eurjchem.5.3.517-525.1072 | Get rights and content

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A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents


Shawkat Ahmed Abdelmohsen (1,*)

(1) Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt
(*) Corresponding Author

Received: 10 Apr 2014 | Revised: 29 May 2014 | Accepted: 06 Jun 2014 | Published: 30 Sep 2014 | Issue Date: September 2014

Abstract


Synthesis of ethyl 6-(8-hydroxyquinolin-5-yl)-3-methylpyridazin-4-carboxylate (4) via one-pot three component reaction of ethyl acetoacetate with (8-hydroxyquinolin-5-yl)(oxo) acetaldehyde (2) in the presence of hydrazine hydrate at room temperature in water was described. A new series of heterocyclic moieties such as oxadiazoles, triazoles, pyrazoles and Schiff bases were prepared and characterized. The structures of the newly synthesized compounds were established by elemental and spectral data. The antimicrobial activity of some of the synthesized compounds was examined against two Gram‐positive bacteria, two Gram‐negative bacteria and four fungi. The results showed that the tested compounds exhibited significant to moderate antimicrobial.


Keywords


Triazoles; Pyrazoles; Pyridazines; Oxadiazoles; One-pot reaction; Antimicrobial activity

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DOI: 10.5155/eurjchem.5.3.517-525.1072

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[1]. A. V. Velikorodov, E. A. Shustova
Synthesis and some transformations of methyl [4-(oxoacetyl)phenyl]carbamate
Russian Journal of Organic Chemistry  53(1), 82, 2017
DOI: 10.1134/S1070428017010146
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How to cite


Abdelmohsen, S. Eur. J. Chem. 2014, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072
Abdelmohsen, S. A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents. Eur. J. Chem. 2014, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072
Abdelmohsen, S. (2014). A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents. European Journal of Chemistry, 5(3), 517-525. doi:10.5155/eurjchem.5.3.517-525.1072
Abdelmohsen, Shawkat. "A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents." European Journal of Chemistry [Online], 5.3 (2014): 517-525. Web. 25 Feb. 2021
Abdelmohsen, Shawkat. "A convenient synthesis and preparation of the derivatives of ethyl-6-(8-hydroxyquinolin-5-yl)-3-methylpyridazine-4-carboxylate as antimicrobial agents" European Journal of Chemistry [Online], Volume 5 Number 3 (30 September 2014)

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