OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Synthesis and study of antimicrobial activity of new tetralone esters
Krishna Mudeenahally Hucchegowda (1) , Basavaraju Yeriyur Basavaiah (2,*) , Umesha Basavaiah (3) , Shivakumar Santhekasalagere Basavaiah (4)
(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(*) Corresponding Author
Received: 17 May 2014 | Revised: 28 Jun 2014 | Accepted: 01 Jul 2014 | Published: 31 Dec 2014 | Issue Date: December 2014
Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities.
Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.
1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).
2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).
3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).
European Journal of Chemistry
Links for Article
| | | | | | |
| | | | | | |
| | | |
Article MetricsThis Abstract was viewed 1360 times | PDF Article downloaded 668 times
Central Drug Research Institute (CDRI), Lucknow and Indian Institute of Technology (IIT), Chennai, India
. Smissman, E. E.; Murray, R. J.; McChesney, J. D. J. Med. Chem. 1976, 19, 148-153.
. Jungi, W. F.; Senn, H. J. Cancer Chemother. Rep. 1975, 59, 737-742.
. Podwyssotzki, V. Arch. Exp. Pathol. Pharmakol. 1880, 13, 29-52.
. Jackson, D. E.; Dewick, P. M. Phytochemistry 1985, 24, 2407-2409.
. Yalamati, D.; William, L. Curr. Med. Chem. 1998, 5, 205-252.
. Kelly, M. G.; Hartwell, J. L. J. Natl. Cancer Inst. 1954, 14, 967-1010.
. Canel, C.; Moraes, R. M.; Dayan, F. E.; Ferreira, D. Phytochemistry 2000, 54, 115-120.
. Imbert, T. F. Biochimie 1998, 80(3), 207-222.
. Gordaliza, M.; Garcia, P. A.; Miguel del Corral, J. M.; Castro, M. A.; Gomez-Zurita, M. A. Toxicon 2004, 44, 441-459.
. Rivera, G. Cancer Chemother. Rep. 1975, 59, 743-749.
. Sathisha, A. D.; Hemakumar, K. H.; Basavaraju, Y. B. Ind. J. Heterocycl. Chem. 2007, 17, 15-18.
. Lee, C. T. L.; Lin, V. C. K. Bioorg. Med. Chem. Lett. 1997, 7, 2897-2902.
. Bauer, A. W.; Kirby, W. M.; Sherris, J. C. Am. J. Clin. Pathol. 1966, 39, 493-496.
. Booth, J.; Boyland, E. Biochem. J. 1966, 34, 125-135.
. Basavaraju, Y. B.; Raju, D.; Anupama, N. Int. J. Pharm. Sci. Rev. Res. 2013, 21, 305-309.
. Umesha, B.; Basavaraju, Y. B. Eur. J. Chem. 2013, 4(3), 235‐239.
. Sadashivamurthy, B.; Basavaraju, Y. B. Ind. J. Heterocycl. Chem. 2006, 15, 259-262.
. Furniss, B. S.; Hannaford, A. J.; Smith, P. W. G.; Tatchell, A. R. Vogels text book of practical organic chemistry, 5th edition, ELBS Longman, New York, 1989.
. Lokanatha Rai, K. M.; Murthy, C. A.; Radhakrishna, P. M. Synth. Commun. 1990, 20, 1273-1277.
. Vyas, D. M.; Skonezhy, M. P.; Jenkins, T. A.; Doyle, T. W. Tetrahedron Lett. 1986, 27, 3099-3102.
. Sadashivamurthy, B.; Basavaraju, Y. B. Bulg. Chem. Commun. 2005, 37, 135-139.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.5.4.584-587.1093
| | | | | | | |
| | | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2014, 5(4), 584-587 | doi: https://doi.org/10.5155/eurjchem.5.4.584-587.1093 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.