European Journal of Chemistry 2014, 5(4), 584-587 | doi: https://doi.org/10.5155/eurjchem.5.4.584-587.1093 | Get rights and content






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Synthesis and study of antimicrobial activity of new tetralone esters


Krishna Mudeenahally Hucchegowda (1) , Basavaraju Yeriyur Basavaiah (2,*) , Umesha Basavaiah (3) , Shivakumar Santhekasalagere Basavaiah (4)

(1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(*) Corresponding Author

Received: 17 May 2014 | Revised: 28 Jun 2014 | Accepted: 01 Jul 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities.


Keywords


Tetralone esters; Cyclopropanation; Antimicrobial activity; Friedel-Crafts acylation; Claisen-Schmidt reaction; Ethyl monochloro acetate

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DOI: 10.5155/eurjchem.5.4.584-587.1093

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Funding information


Central Drug Research Institute (CDRI), Lucknow and Indian Institute of Technology (IIT), Chennai, India

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How to cite


Hucchegowda, K.; Basavaiah, B.; Basavaiah, U.; Basavaiah, S. Eur. J. Chem. 2014, 5(4), 584-587. doi:10.5155/eurjchem.5.4.584-587.1093
Hucchegowda, K.; Basavaiah, B.; Basavaiah, U.; Basavaiah, S. Synthesis and study of antimicrobial activity of new tetralone esters. Eur. J. Chem. 2014, 5(4), 584-587. doi:10.5155/eurjchem.5.4.584-587.1093
Hucchegowda, K., Basavaiah, B., Basavaiah, U., & Basavaiah, S. (2014). Synthesis and study of antimicrobial activity of new tetralone esters. European Journal of Chemistry, 5(4), 584-587. doi:10.5155/eurjchem.5.4.584-587.1093
Hucchegowda, Krishna, Basavaraju Yeriyur Basavaiah, Umesha Basavaiah, & Shivakumar Santhekasalagere Basavaiah. "Synthesis and study of antimicrobial activity of new tetralone esters." European Journal of Chemistry [Online], 5.4 (2014): 584-587. Web. 2 Jun. 2020
Hucchegowda, Krishna, Basavaiah, Basavaraju, Basavaiah, Umesha, AND Basavaiah, Shivakumar. "Synthesis and study of antimicrobial activity of new tetralone esters" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

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DOI Link: https://doi.org/10.5155/eurjchem.5.4.584-587.1093

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