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Synthesis and study of antimicrobial activity of new tetralone esters
Krishna Mudeenahally Hucchegowda (1)
, Basavaraju Yeriyur Basavaiah (2,*) , Umesha Basavaiah (3) , Shivakumar Santhekasalagere Basavaiah (4) (1) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(3) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(4) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
(*) Corresponding Author
Received: 17 May 2014 | Revised: 28 Jun 2014 | Accepted: 01 Jul 2014 | Published: 31 Dec 2014 | Issue Date: December 2014
Abstract
Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities.
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DOI: 10.5155/eurjchem.5.4.584-587.1093
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Central Drug Research Institute (CDRI), Lucknow and Indian Institute of Technology (IIT), Chennai, India
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DOI Link: https://doi.org/10.5155/eurjchem.5.4.584-587.1093
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European Journal of Chemistry 2014, 5(4), 584-587 | doi: https://doi.org/10.5155/eurjchem.5.4.584-587.1093 | Get rights and content
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