European Journal of Chemistry

Synthesis and study of antimicrobial activity of new tetralone esters

Article Sidebar

PDF
Published: Dec 31, 2014
DOI: https://doi.org/10.5155/eurjchem.5.4.584-587.1093
Keywords:
Tetralone esters, Cyclopropanation, Antimicrobial activity, Friedel-Crafts acylation, Claisen-Schmidt reaction, Ethyl monochloro acetate
Section
Research Article
Issue
Vol. 5 No. 4 (2014): December 2014
Dates
Received 2014-05-17
Accepted 2014-07-01
Published 2014-12-31


Main Article Content

Krishna Mudeenahally Hucchegowda
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Basavaraju Yeriyur Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Umesha Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India
Shivakumar Santhekasalagere Basavaiah
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, Karnataka, India

Abstract

Podophyllotoxin belongs to the class of cyclolignan family of natural products, which exhibits strong antimitotic, anti-AIDS (HIV), antitropical skin disease, antimalarial, virucidal, fungicidal and other biological activities. The new tetralone esters (9a-d) of podophyllotoxin analogues were synthesized in good yields by chalcone route to study their structure-activity relationship. All the products obtained were characterized by spectral and elemental analysis data and they were screened for antimicrobial activity. Compounds 9b and 9c were shown significant antibacterial and antifungal activities.


icon graph This Abstract was viewed 1694 times | icon graph Article PDF downloaded 913 times

How to Cite
(1)
Hucchegowda, K. M.; Basavaiah, B. Y.; Basavaiah, U.; Basavaiah, S. S. Synthesis and Study of Antimicrobial Activity of New Tetralone Esters. Eur. J. Chem. 2014, 5, 584-587.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Smissman, E. E.; Murray, R. J.; McChesney, J. D. J. Med. Chem. 1976, 19, 148-153.
http://dx.doi.org/10.1021/jm00223a025

[2]. Jungi, W. F.; Senn, H. J. Cancer Chemother. Rep. 1975, 59, 737-742.

[3]. Podwyssotzki, V. Arch. Exp. Pathol. Pharmakol. 1880, 13, 29-52.
http://dx.doi.org/10.1007/BF01833268

[4]. Jackson, D. E.; Dewick, P. M. Phytochemistry 1985, 24, 2407-2409.
http://dx.doi.org/10.1016/S0031-9422(00)83052-6

[5]. Yalamati, D.; William, L. Curr. Med. Chem. 1998, 5, 205-252.

[6]. Kelly, M. G.; Hartwell, J. L. J. Natl. Cancer Inst. 1954, 14, 967-1010.

[7]. Canel, C.; Moraes, R. M.; Dayan, F. E.; Ferreira, D. Phytochemistry 2000, 54, 115-120.
http://dx.doi.org/10.1016/S0031-9422(00)00094-7

[8]. Imbert, T. F. Biochimie 1998, 80(3), 207-222.
http://dx.doi.org/10.1016/S0300-9084(98)80004-7

[9]. Gordaliza, M.; Garcia, P. A.; Miguel del Corral, J. M.; Castro, M. A.; Gomez-Zurita, M. A. Toxicon 2004, 44, 441-459.
http://dx.doi.org/10.1016/j.toxicon.2004.05.008

[10]. Rivera, G. Cancer Chemother. Rep. 1975, 59, 743-749.

[11]. Sathisha, A. D.; Hemakumar, K. H.; Basavaraju, Y. B. Ind. J. Heterocycl. Chem. 2007, 17, 15-18.

[12]. Lee, C. T. L.; Lin, V. C. K. Bioorg. Med. Chem. Lett. 1997, 7, 2897-2902.
http://dx.doi.org/10.1016/S0960-894X(97)10108-1

[13]. Bauer, A. W.; Kirby, W. M.; Sherris, J. C. Am. J. Clin. Pathol. 1966, 39, 493-496.

[14]. Booth, J.; Boyland, E. Biochem. J. 1966, 34, 125-135.

[15]. Basavaraju, Y. B.; Raju, D.; Anupama, N. Int. J. Pharm. Sci. Rev. Res. 2013, 21, 305-309.

[16]. Umesha, B.; Basavaraju, Y. B. Eur. J. Chem. 2013, 4(3), 235‐239.
http://dx.doi.org/10.5155/eurjchem.4.3.235-239.782

[17]. Sadashivamurthy, B.; Basavaraju, Y. B. Ind. J. Heterocycl. Chem. 2006, 15, 259-262.

[18]. Furniss, B. S.; Hannaford, A. J.; Smith, P. W. G.; Tatchell, A. R. Vogels text book of practical organic chemistry, 5th edition, ELBS Longman, New York, 1989.

[19]. Lokanatha Rai, K. M.; Murthy, C. A.; Radhakrishna, P. M. Synth. Commun. 1990, 20, 1273-1277.
http://dx.doi.org/10.1080/00397919008052837

[20]. Vyas, D. M.; Skonezhy, M. P.; Jenkins, T. A.; Doyle, T. W. Tetrahedron Lett. 1986, 27, 3099-3102.
http://dx.doi.org/10.1016/S0040-4039(00)84725-5

[21]. Sadashivamurthy, B.; Basavaraju, Y. B. Bulg. Chem. Commun. 2005, 37, 135-139.

Supporting Agencies

Central Drug Research Institute (CDRI), Lucknow and Indian Institute of Technology (IIT), Chennai, India
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).