European Journal of Chemistry 2014, 5(4), 628-634 | doi: https://doi.org/10.5155/eurjchem.5.4.628-634.1120 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis and biological evaluation of new quinazolinone derivatives


Firyal Weli Asker (1) , Salma Abdul Rudha Abbas (2,*) , Redha Ibrahim Al-Bayati (3) , Hanaa Abd Al-Tamemi (4)

(1) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author

Received: 12 Jul 2014 | Revised: 01 Aug 2014 | Accepted: 15 Aug 2014 | Published: 31 Dec 2014 | Issue Date: December 2014

Abstract


New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.


Keywords


Schiff bases; Azetidinone; Quinazolinone; Enzymes activities; Antioxidant activity; Antimicrobial activity

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.5.4.628-634.1120

Links for Article


| | | | | | |

| | | | | | |

| | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1160 times | icon graph PDF Article downloaded 545 times

Funding information


Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq

Cited by

Crossref database responds too late...

References


[1]. Hassanzadeh, F.; Jafari, E.; Hakimelahi, G. H.; Rahmani Khajouei, M.; Jalali, M.; Khodarahmi, G. A. Res. Pharm. Sci. 2012, 7(2), 87-94.

[2]. Hong, Z.; Hai, Y. H.; Yuan, Y, H.; Xin, G.; Lin, H.; Qiag, R.; Ying, L.; Yang, L. I. Molecules 2010, 15, 9473-9485.

[3]. Suresha, K. G. P.; Prakasha, C.; Kapfo, W.; Channe, G. D. E-Journal Chem. 2010, 7(2), 449-456.
http://dx.doi.org/10.1155/2010/979675

[4]. Xingwen, G.; Xuejian, C.; Kia, Y.; Baoan, S.; Liu, G.; Zhuo, C. Molecules 2007, 12, 2621-2642.
http://dx.doi.org/10.3390/12122621

[5]. Mosaad, S.; Mohsen, M.; Emad, M.; Nageh, A.; Salwa, M.; Marwa, F. Acta. Pol. Pharm. 2009, 66(5), 487-500.

[6]. Kunes, J.; Bazant, J.; Pour, M.; Waisserk, K.; Slosarek, M.; Janota, J. Farmaco 2000, 55, 725-729.
http://dx.doi.org/10.1016/S0014-827X(00)00100-2

[7]. Adel, S.; Mohamed, A.; Alaa, A.; Naglaa, I.; Magda, A.; Abdulaziz, M.; Mohamed, M.; Sami, G. Eur. J. Med. Chem. 2010, 45, 4188-4198.
http://dx.doi.org/10.1016/j.ejmech.2010.06.013

[8]. Sakere, H.; Revanasiddappa, D.; Shiva Prasad, K.; Shiva Kumar, L.; Jayalakshmi, B. Chem. Tech. 2010, 2(2), 1344-1349.

[9]. Rajasekaran, A.; Rajamanickam, V.; Darlinquine, S. Eur. Rev. Med. Pharm. 2013, 17, 95-104.

[10]. Sabir, H. Jyoti, S.; Mohd, A. E-Journal Chem. 2008, 5(4), 963-968.

[11]. Heakal, F.; Fouda, A. S.; Radwan, M. S. Int. J. Electrochem. Sci. 2011, 6, 3140-3163.

[12]. Deng, X. Q.; Dong, Z. Q.; Song, M. X.; Shu, B.; Wang, S. B.; Quan, Z. S. Arch. Pharm. 2012, 345(7), 565-573.
http://dx.doi.org/10.1002/ardp.201100326

[13]. Firas, H. Int. J. Res. Pharm. Chem. 2012, 2(1), 2231-2781.

[14]. Oana Maria, D.; Florentina, L.; Cornelia, V.; Mihai, M.; Valentin, N.; Romona, F.; Dragos, P.; Lenuta, P. Molecules 2013, 18, 4140-4157.
http://dx.doi.org/10.3390/molecules18044140

[15]. Nikalje G.; Ghodke S.; Mirza S. World J. Pharm. Pharmaceut. Sci. 2014, 3(2), 2589-2625.

[16]. Al-Qaisi, Z. H. J.; Abbass, S. A. R.; Abdullah, A. H. Int. J. Chem. 2011, 3(2), 140-148.
http://dx.doi.org/10.5539/ijc.v3n2p140

[17]. Stryer, L. Biochemistry, 3rd Edition, W. H. Freeman and Company, New York, 2005.

[18]. Thommas, M.; Devlin J. Text of Biochemistry with Clinical Correlations, 7th Edition, Medical Publication, New York, 2011.

[19]. Harry, R.; Mathews, A.; Preed, L. Biochemistry a short course, 5th Edition, Wiley-Liss, U.S.A, 2012.

[20]. Aldo, P.; Roberto, T.; Patrizia, T.; Mario, C.; Alfonso, P. Free Radical Bio. Med. 1997, 22(5), 853-860.
http://dx.doi.org/10.1016/S0891-5849(96)00422-4

[21]. Cyril, P.; Duran, S. J. Heterocyclic Chem. 2000, 37(4), 725-729.
http://dx.doi.org/10.1002/jhet.5570370409

[22]. Greenwood, D.; Snack, R.; Peurtherer, J. Medical Microbiology: A Guid to Microbial Infections: Pathogensis, Immunity, Laboratory Diagnosis and Control, 15th Edition, Churchill Livingstne, Edinburgh, United Kingdom, 1997, p 690.

[23]. Osorio, M.; Aravena, J.; Vergara, A.; Taborga, L.; Baeza, E.; Catalan, K.; Gonzalez, C.; Carvajal, M.; Carrasco, H.; Espinoza, L. Molecules 2012, 17, 556-570.
http://dx.doi.org/10.3390/molecules17010556

[24]. Britman, S.; Frankel, S. Am. J. Clin. Path. 1957, 28(1), 56-63.

[25]. Persijn, J. P.; Van Der, S. W. J. Clin. Chem. Clin. Biochem. 1976, 14(9), 421-427.

[26]. Pesce, A. J.; Kaplan, L. A. Methods in clinical chemistry, 3rd Edition, Mosby Company, New Delhi, 1987.


How to cite


Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Synthesis and biological evaluation of new quinazolinone derivatives. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F., Abbas, S., Al-Bayati, R., & Al-Tamemi, H. (2014). Synthesis and biological evaluation of new quinazolinone derivatives. European Journal of Chemistry, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, Firyal, Salma Abdul Rudha Abbas, Redha Ibrahim Al-Bayati, & Hanaa Abd Al-Tamemi. "Synthesis and biological evaluation of new quinazolinone derivatives." European Journal of Chemistry [Online], 5.4 (2014): 628-634. Web. 16 Jun. 2021
Asker, Firyal, Abbas, Salma, Al-Bayati, Redha, AND Al-Tamemi, Hanaa. "Synthesis and biological evaluation of new quinazolinone derivatives" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.5.4.628-634.1120

CrossRef | Scilit | GrowKudos | Researchgate | Publons | Microsoft | scibey | Scite | Lens | OUCI

WorldCat Paperbuzz Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2014, 5(4), 628-634 | doi: https://doi.org/10.5155/eurjchem.5.4.628-634.1120 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2021  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2021 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.