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Synthesis and biological evaluation of new quinazolinone derivatives
Firyal Weli Asker (1)
, Salma Abdul Rudha Abbas (2,*) , Redha Ibrahim Al-Bayati (3) , Hanaa Abd Al-Tamemi (4) (1) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author
Received: 12 Jul 2014 | Revised: 01 Aug 2014 | Accepted: 15 Aug 2014 | Published: 31 Dec 2014 | Issue Date: December 2014
Abstract
New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.
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DOI: 10.5155/eurjchem.5.4.628-634.1120
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Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
Citations
[1]. Leqaa A Mohammed, Olfat A Nief, Firyal W Askar, Abdulwahhab H Majeed
Synthesis, Characterization and Antimicrobial Activities of Silver Nanoparticles coated [1,3] Thiazin-4-One derivatives
Journal of Physics: Conference Series 1294(5), 052028, 2019
DOI: 10.1088/1742-6596/1294/5/052028
[2]. Nawal Daamy Resen, Asia Hameed Abed, Albayati Zeyad sefauldeen, Askar Firyal Weli, Thoraia M. Alkhaisy
Metal Complexes of acetohydrazide Derivative: Characterization, and Antimicrobial Activity Study
Journal of Physics: Conference Series 1664(1), 012087, 2020
DOI: 10.1088/1742-6596/1664/1/012087
[3]. Xinyang Lv, Lan Yang, Zhijiang Fan, Xiaoping Bao
Synthesis and antimicrobial activities of novel quinazolin-4(3 H )-one derivatives containing a 1,2,4-triazolo[3,4- b ][1,3,4]thiadiazole moiety
Journal of Saudi Chemical Society 22(1), 101, 2018
DOI: 10.1016/j.jscs.2017.07.008
[4]. Bo-Ren Yan, Xin-Yang Lv, Huan Du, Man-Ni Gao, Jian Huang, Xiao-Ping Bao
Synthesis and biological activities of novel quinazolinone derivatives containing a 1,2,4-triazolylthioether moiety
Chemical Papers 70(7), , 2016
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[5]. Jing Li, Martin Berger, Wojciech Zawodny, Marwan Simaan, Nuno Maulide
A Chemoselective α-Oxytriflation Enables the Direct Asymmetric Arylation of Amides
Chem 5(7), 1883, 2019
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DOI Link: https://doi.org/10.5155/eurjchem.5.4.628-634.1120
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European Journal of Chemistry 2014, 5(4), 628-634 | doi: https://doi.org/10.5155/eurjchem.5.4.628-634.1120 | Get rights and content
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