European Journal of Chemistry

Synthesis and biological evaluation of new quinazolinone derivatives

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Firyal Weli Asker
Salma Abdul Rudha Abbas
Redha Ibrahim Al-Bayati
Hanaa Abd Al-Tamemi


New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.

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How to Cite
Asker, F. W.; Abbas, S. A. R.; Al-Bayati, R. I.; Al-Tamemi, H. A. Synthesis and Biological Evaluation of New Quinazolinone Derivatives. Eur. J. Chem. 2014, 5, 628-634.

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