European Journal of Chemistry

Synthesis and biological evaluation of new quinazolinone derivatives



Main Article Content

Firyal Weli Asker
Salma Abdul Rudha Abbas
Redha Ibrahim Al-Bayati
Hanaa Abd Al-Tamemi

Abstract

New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.


icon graph This Abstract was viewed 1707 times | icon graph Article PDF downloaded 848 times

How to Cite
(1)
Asker, F. W.; Abbas, S. A. R.; Al-Bayati, R. I.; Al-Tamemi, H. A. Synthesis and Biological Evaluation of New Quinazolinone Derivatives. Eur. J. Chem. 2014, 5, 628-634.

Article Details

Share
Crossref - Scopus - Google - European PMC
References

[1]. Hassanzadeh, F.; Jafari, E.; Hakimelahi, G. H.; Rahmani Khajouei, M.; Jalali, M.; Khodarahmi, G. A. Res. Pharm. Sci. 2012, 7(2), 87-94.

[2]. Hong, Z.; Hai, Y. H.; Yuan, Y, H.; Xin, G.; Lin, H.; Qiag, R.; Ying, L.; Yang, L. I. Molecules 2010, 15, 9473-9485.

[3]. Suresha, K. G. P.; Prakasha, C.; Kapfo, W.; Channe, G. D. E-Journal Chem. 2010, 7(2), 449-456.
http://dx.doi.org/10.1155/2010/979675

[4]. Xingwen, G.; Xuejian, C.; Kia, Y.; Baoan, S.; Liu, G.; Zhuo, C. Molecules 2007, 12, 2621-2642.
http://dx.doi.org/10.3390/12122621

[5]. Mosaad, S.; Mohsen, M.; Emad, M.; Nageh, A.; Salwa, M.; Marwa, F. Acta. Pol. Pharm. 2009, 66(5), 487-500.

[6]. Kunes, J.; Bazant, J.; Pour, M.; Waisserk, K.; Slosarek, M.; Janota, J. Farmaco 2000, 55, 725-729.
http://dx.doi.org/10.1016/S0014-827X(00)00100-2

[7]. Adel, S.; Mohamed, A.; Alaa, A.; Naglaa, I.; Magda, A.; Abdulaziz, M.; Mohamed, M.; Sami, G. Eur. J. Med. Chem. 2010, 45, 4188-4198.
http://dx.doi.org/10.1016/j.ejmech.2010.06.013

[8]. Sakere, H.; Revanasiddappa, D.; Shiva Prasad, K.; Shiva Kumar, L.; Jayalakshmi, B. Chem. Tech. 2010, 2(2), 1344-1349.

[9]. Rajasekaran, A.; Rajamanickam, V.; Darlinquine, S. Eur. Rev. Med. Pharm. 2013, 17, 95-104.

[10]. Sabir, H. Jyoti, S.; Mohd, A. E-Journal Chem. 2008, 5(4), 963-968.

[11]. Heakal, F.; Fouda, A. S.; Radwan, M. S. Int. J. Electrochem. Sci. 2011, 6, 3140-3163.

[12]. Deng, X. Q.; Dong, Z. Q.; Song, M. X.; Shu, B.; Wang, S. B.; Quan, Z. S. Arch. Pharm. 2012, 345(7), 565-573.
http://dx.doi.org/10.1002/ardp.201100326

[13]. Firas, H. Int. J. Res. Pharm. Chem. 2012, 2(1), 2231-2781.

[14]. Oana Maria, D.; Florentina, L.; Cornelia, V.; Mihai, M.; Valentin, N.; Romona, F.; Dragos, P.; Lenuta, P. Molecules 2013, 18, 4140-4157.
http://dx.doi.org/10.3390/molecules18044140

[15]. Nikalje G.; Ghodke S.; Mirza S. World J. Pharm. Pharmaceut. Sci. 2014, 3(2), 2589-2625.

[16]. Al-Qaisi, Z. H. J.; Abbass, S. A. R.; Abdullah, A. H. Int. J. Chem. 2011, 3(2), 140-148.
http://dx.doi.org/10.5539/ijc.v3n2p140

[17]. Stryer, L. Biochemistry, 3rd Edition, W. H. Freeman and Company, New York, 2005.

[18]. Thommas, M.; Devlin J. Text of Biochemistry with Clinical Correlations, 7th Edition, Medical Publication, New York, 2011.

[19]. Harry, R.; Mathews, A.; Preed, L. Biochemistry a short course, 5th Edition, Wiley-Liss, U.S.A, 2012.

[20]. Aldo, P.; Roberto, T.; Patrizia, T.; Mario, C.; Alfonso, P. Free Radical Bio. Med. 1997, 22(5), 853-860.
http://dx.doi.org/10.1016/S0891-5849(96)00422-4

[21]. Cyril, P.; Duran, S. J. Heterocyclic Chem. 2000, 37(4), 725-729.
http://dx.doi.org/10.1002/jhet.5570370409

[22]. Greenwood, D.; Snack, R.; Peurtherer, J. Medical Microbiology: A Guid to Microbial Infections: Pathogensis, Immunity, Laboratory Diagnosis and Control, 15th Edition, Churchill Livingstne, Edinburgh, United Kingdom, 1997, p 690.

[23]. Osorio, M.; Aravena, J.; Vergara, A.; Taborga, L.; Baeza, E.; Catalan, K.; Gonzalez, C.; Carvajal, M.; Carrasco, H.; Espinoza, L. Molecules 2012, 17, 556-570.
http://dx.doi.org/10.3390/molecules17010556

[24]. Britman, S.; Frankel, S. Am. J. Clin. Path. 1957, 28(1), 56-63.

[25]. Persijn, J. P.; Van Der, S. W. J. Clin. Chem. Clin. Biochem. 1976, 14(9), 421-427.

[26]. Pesce, A. J.; Kaplan, L. A. Methods in clinical chemistry, 3rd Edition, Mosby Company, New Delhi, 1987.

Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).