European Journal of Chemistry 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120

Synthesis and biological evaluation of new quinazolinone derivatives


Firyal Weli Asker (1) , Salma Abdul Rudha Abbas (2,*) , Redha Ibrahim Al-Bayati (3) , Hanaa Abd Al-Tamemi (4)

(1) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(2) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(3) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(4) Department of Chemistry, College of Science, Al-Mustansiriya University, 10052, Baghdad, Iraq
(*) Corresponding Author

Received: 12 Jul 2014, Accepted: 15 Aug 2014, Published: 31 Dec 2014

Abstract


New N-substituted-2-methyl quinazolin-4(3H)-ones derivatives comprising 1,3,4-thiadiazole, Schiff bases and 2-azetidinone moieties are reported. The structures of the newly prepared compounds were confirmed by FT-IR and 1H NMR spectra. The compounds were also evaluated for their antimicrobial, antioxidant and study of inhibition on some enzymes activities. The results suggest that the compounds possess broad spectrum of in-vitro antimicrobial activity. Antioxidant results obtained into the present study indicate that compound 5 show moderate better scavenging activity. Compound 5 demonstrated inhibitory effects on GOT, GPT, GGT and ALP activities, and these effects increase with increasing the concentration of the compound.


Keywords


Schiff bases; Azetidinone; Quinazolinone; Enzymes activities; Antioxidant activity; Antimicrobial activity

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DOI: 10.5155/eurjchem.5.4.628-634.1120

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[2]. Xinyang Lv, Lan Yang, Zhijiang Fan, Xiaoping Bao
Synthesis and antimicrobial activities of novel quinazolin-4(3 H )-one derivatives containing a 1,2,4-triazolo[3,4- b ][1,3,4]thiadiazole moiety
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[3]. Jing Li, Martin Berger, Wojciech Zawodny, Marwan Simaan, Nuno Maulide
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References

[1]. Hassanzadeh, F.; Jafari, E.; Hakimelahi, G. H.; Rahmani Khajouei, M.; Jalali, M.; Khodarahmi, G. A. Res. Pharm. Sci. 2012, 7(2), 87-94.

[2]. Hong, Z.; Hai, Y. H.; Yuan, Y, H.; Xin, G.; Lin, H.; Qiag, R.; Ying, L.; Yang, L. I. Molecules 2010, 15, 9473-9485.

[3]. Suresha, K. G. P.; Prakasha, C.; Kapfo, W.; Channe, G. D. E-Journal Chem. 2010, 7(2), 449-456.
http://dx.doi.org/10.1155/2010/979675

[4]. Xingwen, G.; Xuejian, C.; Kia, Y.; Baoan, S.; Liu, G.; Zhuo, C. Molecules 2007, 12, 2621-2642.
http://dx.doi.org/10.3390/12122621

[5]. Mosaad, S.; Mohsen, M.; Emad, M.; Nageh, A.; Salwa, M.; Marwa, F. Acta. Pol. Pharm. 2009, 66(5), 487-500.

[6]. Kunes, J.; Bazant, J.; Pour, M.; Waisserk, K.; Slosarek, M.; Janota, J. Farmaco 2000, 55, 725-729.
http://dx.doi.org/10.1016/S0014-827X(00)00100-2

[7]. Adel, S.; Mohamed, A.; Alaa, A.; Naglaa, I.; Magda, A.; Abdulaziz, M.; Mohamed, M.; Sami, G. Eur. J. Med. Chem. 2010, 45, 4188-4198.
http://dx.doi.org/10.1016/j.ejmech.2010.06.013

[8]. Sakere, H.; Revanasiddappa, D.; Shiva Prasad, K.; Shiva Kumar, L.; Jayalakshmi, B. Chem. Tech. 2010, 2(2), 1344-1349.

[9]. Rajasekaran, A.; Rajamanickam, V.; Darlinquine, S. Eur. Rev. Med. Pharm. 2013, 17, 95-104.

[10]. Sabir, H. Jyoti, S.; Mohd, A. E-Journal Chem. 2008, 5(4), 963-968.

[11]. Heakal, F.; Fouda, A. S.; Radwan, M. S. Int. J. Electrochem. Sci. 2011, 6, 3140-3163.

[12]. Deng, X. Q.; Dong, Z. Q.; Song, M. X.; Shu, B.; Wang, S. B.; Quan, Z. S. Arch. Pharm. 2012, 345(7), 565-573.
http://dx.doi.org/10.1002/ardp.201100326

[13]. Firas, H. Int. J. Res. Pharm. Chem. 2012, 2(1), 2231-2781.

[14]. Oana Maria, D.; Florentina, L.; Cornelia, V.; Mihai, M.; Valentin, N.; Romona, F.; Dragos, P.; Lenuta, P. Molecules 2013, 18, 4140-4157.
http://dx.doi.org/10.3390/molecules18044140

[15]. Nikalje G.; Ghodke S.; Mirza S. World J. Pharm. Pharmaceut. Sci. 2014, 3(2), 2589-2625.

[16]. Al-Qaisi, Z. H. J.; Abbass, S. A. R.; Abdullah, A. H. Int. J. Chem. 2011, 3(2), 140-148.
http://dx.doi.org/10.5539/ijc.v3n2p140

[17]. Stryer, L. Biochemistry, 3rd Edition, W. H. Freeman and Company, New York, 2005.

[18]. Thommas, M.; Devlin J. Text of Biochemistry with Clinical Correlations, 7th Edition, Medical Publication, New York, 2011.

[19]. Harry, R.; Mathews, A.; Preed, L. Biochemistry a short course, 5th Edition, Wiley-Liss, U.S.A, 2012.

[20]. Aldo, P.; Roberto, T.; Patrizia, T.; Mario, C.; Alfonso, P. Free Radical Bio. Med. 1997, 22(5), 853-860.
http://dx.doi.org/10.1016/S0891-5849(96)00422-4

[21]. Cyril, P.; Duran, S. J. Heterocyclic Chem. 2000, 37(4), 725-729.
http://dx.doi.org/10.1002/jhet.5570370409

[22]. Greenwood, D.; Snack, R.; Peurtherer, J. Medical Microbiology: A Guid to Microbial Infections: Pathogensis, Immunity, Laboratory Diagnosis and Control, 15th Edition, Churchill Livingstne, Edinburgh, United Kingdom, 1997, p 690.

[23]. Osorio, M.; Aravena, J.; Vergara, A.; Taborga, L.; Baeza, E.; Catalan, K.; Gonzalez, C.; Carvajal, M.; Carrasco, H.; Espinoza, L. Molecules 2012, 17, 556-570.
http://dx.doi.org/10.3390/molecules17010556

[24]. Britman, S.; Frankel, S. Am. J. Clin. Path. 1957, 28(1), 56-63.

[25]. Persijn, J. P.; Van Der, S. W. J. Clin. Chem. Clin. Biochem. 1976, 14(9), 421-427.

[26]. Pesce, A. J.; Kaplan, L. A. Methods in clinical chemistry, 3rd Edition, Mosby Company, New Delhi, 1987.


How to cite


Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F.; Abbas, S.; Al-Bayati, R.; Al-Tamemi, H. Synthesis and biological evaluation of new quinazolinone derivatives. Eur. J. Chem. 2014, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, F., Abbas, S., Al-Bayati, R., & Al-Tamemi, H. (2014). Synthesis and biological evaluation of new quinazolinone derivatives. European Journal of Chemistry, 5(4), 628-634. doi:10.5155/eurjchem.5.4.628-634.1120
Asker, Firyal, Salma Abdul Rudha Abbas, Redha Ibrahim Al-Bayati, & Hanaa Abd Al-Tamemi. "Synthesis and biological evaluation of new quinazolinone derivatives." European Journal of Chemistry [Online], 5.4 (2014): 628-634. Web. 19 Nov. 2019
Asker, Firyal, Abbas, Salma, Al-Bayati, Redha, AND Al-Tamemi, Hanaa. "Synthesis and biological evaluation of new quinazolinone derivatives" European Journal of Chemistry [Online], Volume 5 Number 4 (31 December 2014)

DOI Link: https://doi.org/10.5155/eurjchem.5.4.628-634.1120

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