

Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives
Mohammad Mahmoud Ibrahim (1,*)

(1) Department of Chemistry, Faculty of Sciences, University of Al Al-Bayt, Al-Mafraq, 25113, Jordan
(*) Corresponding Author
Received: 08 Sep 2014 | Revised: 07 Oct 2014 | Accepted: 07 Oct 2014 | Published: 31 Mar 2015 | Issue Date: March 2015
Abstract
A new series of substituted pyrazolines (6-10) were synthesized in moderate to excellent yield by treatment of chalcones (1-5) with hydrazine monohydrate. The carbothioamide compounds (11-14) were obtained in 65% to quantitative yield by treatment of chalcones (2, 4, and 5) either with thiosemicarbazide or with phenylisothiocyanate. All new compounds were characterized by various spectroscopic methods such as 1H NMR, 13C NMR, DEPT, COSY, HSQC spectroscopy, elemental analysis, and high resolution mass spectroscopy. The obtained compounds are currently under biological investigations, and the results will be reported elsewhere.
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DOI: 10.5155/eurjchem.6.1.78-83.1148
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Funding information
Al Al-Bayt University (Mafraq, Jordan) and the German Academic Exchange Service (DAAD, Germany)
Citations
[1]. Mohammad Murwih Alidmat, Melati Khairuddean, Naziera Mohammad Norman, Anis Nasihah Mohamed Asri, Mohd Hisyam Mohd Suhaimi, Garima Sharma
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[2]. Raja Ranganathan, Sivasubramaniyan Archana, Murugan Dinesh, George Jaabil, Sangaraiah Nagarajan, Alagusundaram Ponnuswamy, Kanagarajan Saranya, Saminathan Murugavel
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[3]. Hamid Reza Farmani, Mohammad Hossein Mosslemin, Bahareh Sadeghi
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DOI: 10.1007/s11030-018-9814-7

[4]. Mahmoud Al-Refai, Mohammad M. Ibrahim, Sohail Alsohaili, Armin Geyer
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DOI: 10.1080/10426507.2016.1277526

[5]. Mohammad M. Ibrahim, Mahmoud Al-Refai, Khurshid Ayub, Basem F. Ali
Synthesis, Spectral Characterization and Fluorescent Assessment of 1,3,5-Triaryl-2-pyrazoline Derivatives: Experimental and Theoretical Studies
Journal of Fluorescence 26(4), 1447, 2016
DOI: 10.1007/s10895-016-1837-9

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