European Journal of Chemistry

Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives

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Published: Mar 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.1.78-83.1148
Keywords:
Chalcones, Pyrazolines, Isothiocyanate, Carbothioamide, Claisen-Schmidt, Thiosemicarbazide
Section
Research Article
Issue
Vol. 6 No. 1 (2015): March 2015
Dates
Received 2014-09-08
Accepted 2014-10-07
Published 2015-03-31


Main Article Content

Mohammad Mahmoud Ibrahim
Department of Chemistry, Faculty of Sciences, University of Al Al-Bayt, Al-Mafraq, 25113, Jordan

Abstract

A new series of substituted pyrazolines (6-10) were synthesized in moderate to excellent yield by treatment of chalcones (1-5) with hydrazine monohydrate. The carbothioamide compounds (11-14) were obtained in 65% to quantitative yield by treatment of chalcones (2, 4, and 5) either with thiosemicarbazide or with phenylisothiocyanate. All new compounds were characterized by various spectroscopic methods such as 1H NMR, 13C NMR, DEPT, COSY, HSQC spectroscopy, elemental analysis, and high resolution mass spectroscopy. The obtained compounds are currently under biological investigations, and the results will be reported elsewhere.


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Ibrahim, M. M. Synthesis and Characterization of New 3,5-Disubstituted-4,5-Dihydro-1H-Pyrazole and Their Carbothioamide Derivatives. Eur. J. Chem. 2015, 6, 78-83.

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Supporting Agencies

Al Al-Bayt University (Mafraq, Jordan) and the German Academic Exchange Service (DAAD, Germany)
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