European Journal of Chemistry

Stereoselective total synthesis of pectinolide H and 4'-epi-pectinolide H

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Published: Mar 31, 2015
DOI: https://doi.org/10.5155/eurjchem.6.1.93-97.1150
Keywords:
Reduction, Pectinolide H, Lactonization, Swern oxidation, Wittig olefination, Grignard reaction
Section
Research Article
Issue
Vol. 6 No. 1 (2015): March 2015
Dates
Received 2014-09-11
Accepted 2014-10-18
Published 2015-03-31


Main Article Content

Ramesh Perla
Natural Products Chemistry Division, Indian Institute of Chemical Technology, Habsiguda, Hyderabad-500007, India
Nitin Wasantrao Fadnavis
Natural Products Chemistry Division, Indian Institute of Chemical Technology, Habsiguda, Hyderabad-500007, India

Abstract

The total synthesis of pectinolide H and 4'-epi-pectinolide H was accomplished with 27% yield in nine steps from inexpensive and commercially available compound, (+)-diethyl tartrate ((+)DET)) by employing swern oxidation, Wittig olefination, Grignard and lactonization reactions.


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Perla, R.; Fadnavis, N. W. Stereoselective Total Synthesis of Pectinolide H and 4’-Epi-Pectinolide H. Eur. J. Chem. 2015, 6, 93-97.

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Supporting Agencies

University Grants Commission for grant of Senior Research Fellowship to PR and Council of Scientific and Industrial Research, New Delhi for financial assistance under XII 5 year plan CSC0108-ORIGIN
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