OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Determination of voglibose in pharmaceutical formulations by high performance liquid chromatography using refractive index detection
Karunanidhi Lakshmi (1) , Tirumala Rajesh (2,*)
(1) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(2) Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramasamy Memorial University, Kattankulathur, IN-603203, Tamil Nadu, India
(*) Corresponding Author
Received: 20 May 2010 | Revised: 23 Jun 2010 | Accepted: 24 Jun 2010 | Published: 22 Dec 2010 | Issue Date: December 2010
Voglibose is a potent glucosidase inhibitor used for type II diabetes mellitus. A simple and rapid high performance liquid chromatographic method with refractive index detection was developed for the determination of voglibose in pharmaceutical formulations. Development was performed on a C18 (250 x 4.6 mm, 5 µ) column using a mobile phase mixture of acetonitrile and water in the ratio of 50:50 which was fixed at a flow rate of 0.5 mL/min. Polarity of voglibose was found to be positive and elution time was found to be less than 5 min. The method was also validated as per ICH guidelines for its linearity, precision, accuracy and robustness. The limit of detection and quantification (LOD and LOQ) were found to be 2.91 and 9.7 µg/mL. The method could be successfully applied for the quantification of voglibose in pharmaceutical formulations.
Links for Article
| | | | | | |
| | | | | | |
| | | |
Article MetricsThis Abstract was viewed 2090 times | PDF Article downloaded 935 times
University Grants Commission, New Delhi, India
. Masoom Raza Siddiqui, Zeid A. AlOthman, Nafisur Rahman
Analytical techniques in pharmaceutical analysis: A review
Arabian Journal of Chemistry 10, S1409, 2017
. M. K. Mohammad Ziaul Hyder, Shamim Akhtar
Refractive Indices and Related Properties for Binary Mixtures of Methyl Acetate and Derivatives of Alkanolamines at Temperature Ranging from 293.15 to 313.15 K
ECS Journal of Solid State Science and Technology 10(4), 043001, 2021
. R. Solaichamy, J. Karpagam
Structural and Vibrational Studies (FT-IR, FT-Raman) of Voglibose Using DFT Calculation
International Letters of Chemistry, Physics and Astronomy 64, 45, 2016
. Kedar Tejashree R., A.R. Dashetwar, D.P. Kardile, A.P. Jadhav, V.C. Bhagat, R.V. Shete
Q-Absorbance Ratio Spectrophotometric Method for the Simultaneous Estimation of Metformin Hydrochloride and Voglibose in Tablet Dosage form
Research Journal of Pharmacy and Technology , 3179, 2021
. Yongjin Sung
Snapshot Holographic Optical Tomography
Physical Review Applied 11(1), , 2019
. Yamasaki, Y.; Katakami, N.; Hayaishi-Okano, R.; Matsuhisa, M.; Kajimoto, Y.; Kosugi, K.; Hatano, M.; Hori, M. Diabetes Res. Clin. Pract. 2005, 67, 204-210.
. Watanabe, K.; Uchino, H.; Ohmura, C.; Tanaka, Y.; Onuma, T.; Kawamori, R. J. Diabetes Complicat. 2004, 18, 183-186.
. Vichayanrat, A.; Ploybutr, S.; Tunlakit, M.; Watanakejorn, P. Diabetes Res. Clin. Pract. 2002, 55, 99-103.
. Zhang, H.; Sun, C. R.; Ishurd, O.; Pan, Y.J.; Ding, L.S. Carbohydr. Res. 2004, 339, 2027-2030.
. Chen, X.; Zheng, Y.; Shen, Y. Curr. Med. Chem. 2006, 13, 109-116.
. Rethfeld, I.; Blaschke, G. J. Chromatogr. B 1997, 700, 249-253.
. Woo. J. S.; Ryu, J. K. J. Pharm. Biomed. Anal. 2006, 42, 328-333.
. Saiz-Abajo, M. J.; Gonzalez-Saiz, J. M.; Consuelo, P. Anal. Chim. Acta 2005, 528, 63-76.
. ICH Guidelines, Validation of Analytical Procedures: Q2A, 1994.
. ICH Guidelines, Validation of Analytical Procedures: Q2B, 1996.
. ICH Draft Guidelines, Validation of Analytical Procedures: Definitions and Terminology, Federal Register, vol. 60, IFPMA, Switzerland, 1995.
How to cite
The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item
DOI Link: https://doi.org/10.5155/eurjchem.1.4.262-265.116
| | | | | | | | |
| | | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2010, 1(4), 262-265 | doi: https://doi.org/10.5155/eurjchem.1.4.262-265.116 | Get rights and content
- There are currently no refbacks.
© Copyright 2010 - 2022 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2010-2022 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.