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Synthesis, reactions and antimicrobial activity of benzothiazoles
Eman Mostafa Abbas (1,*)
, Marwa Saied Salem (2) , Asmaa Fathy Kassem (3) , Sherein Ismail Abd El-Moez (4) , Mohamed Youssef El-Kady (5) (1) Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Giza, 12622, Egypt
(2) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(3) Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Giza, 12622, Egypt
(4) Microbiology and Immunology Department, Veterinary Division, National Research Center, Dokki, Giza, 12622, Egypt
(5) Synthetic Organic Chemistry Laboratory, Chemistry Department, Faculty of Science, Ain Shams University, Abbasiya, Cairo, 11566, Egypt
(*) Corresponding Author
Received: 23 Sep 2014 | Revised: 16 Dec 2014 | Accepted: 11 Jan 2015 | Published: 30 Jun 2015 | Issue Date: June 2015
Abstract
Benzothiazoles have been proven to be potent antimicrobial agents. In this study, 3-(5,6-dimethoxy-2-oxo-1,3-benzothiazol-3(2H)-yl)propanohydrazide has been utilized as a scaffold for synthesis of pyrrole, indolylidene, pyrazoles, mercaptotriazole, oxadiazole, triazole and oxothiazolidine derivatives. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.6.2.98-106.1161
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Funding information
Microbiology and Immunology Department, Veterinary Division, National Research Center and Microanalytical Center of Cairo University, Cairo, Egypt
Citations
[1]. Eman A. El-Helw, Hamed A. Derbala, Manal M. El-Shahawi, Marwa S. Salem, Mamdouh M. Ali
Synthesis and In Vitro Antitumor Activity of Novel Chromenones Bearing Benzothiazole Moiety
Russian Journal of Bioorganic Chemistry 45(1), 42, 2019
DOI: 10.1134/S1068162019010047
References
[1]. Yamazaki, K.; Kaneko, Y.; Suwa, K.; Ebara, S.; Nakazawa, K.; Yasuno, K. Bioorg. Med. Chem. 2005, 13, 2509-2522.
http://dx.doi.org/10.1016/j.bmc.2005.01.033
[2]. Latrofa, A.; Franco, M.; Lopedota, A.; Rosato, A.; Carone, D.; Vitali, C. IL Farmaco 2005, 60, 291-297.
http://dx.doi.org/10.1016/j.farmac.2005.01.010
[3]. Yalcin, I.; Oren, I.; Sener, E.; Akin, A.; Ucarturk, N. Eur. J. Med. Chem. 1992, 27, 401-406.
http://dx.doi.org/10.1016/0223-5234(92)90154-S
[4]. Bujdakova, H.; Muckova, M. Int. J. Antimicrob. Agents 1994, 4, 303-308.
http://dx.doi.org/10.1016/0924-8579(94)90030-2
[5]. Rajeeva, B.; Srinivasulu, N.; Shantakumar, S. M. Eur. J. Med. Chem. 2009, 6, 775-779.
[6]. Soni, B.; Ranawat, M. S.; Shrma, R.; Bhandari, A.; Sharma, S. Eur. J. Med. Chem. 2010, 45(7), 2938-2942.
http://dx.doi.org/10.1016/j.ejmech.2010.03.019
[7]. El-Emary; T. I.; El-Mohsen, S. A. A. Molecules 2012, 17, 14464-14483.
[8]. Weekes, A. A.; Westwell, A. D. Curr. Med. Chem. 2009, 16, 2430-2440.
http://dx.doi.org/10.2174/092986709788682137
[9]. Kini, S.; Swain, S. P.; Gandhi, A. M. Indian J. Pharm. Sci. 2007, 69, 46-50.
http://dx.doi.org/10.4103/0250-474X.32107
[10]. Lion, C. J.; Matthews, C. S.; Wells, G.; Bradshaw, T. D.; Stevens, M. F. G.; Westwell, A. D. Bioorg. Med. Chem. Lett. 2006, 16, 5005-5008.
http://dx.doi.org/10.1016/j.bmcl.2006.07.072
[11]. Mortimer, C. S.; Wells, G.; Crochard, P. J.; Stone, E. L.; Bradshaw, T. D.; Stevens, M. F. G.; Westwell, A. D. J. Med. Chem. 2006, 49, 179-185.
http://dx.doi.org/10.1021/jm050942k
[12]. Wells, G.; Berry, J. M.; Bradshaw, T. D.; Burger, A. M.; Seaton, A.; Wang, B.; Westwell, A. D.; Stevens, M. F. G. J. Med. Chem. 2003, 46, 532-541.
http://dx.doi.org/10.1021/jm020984y
[13]. Hutchinson, I.; Jennings, S. A.; Vishnuvajjala, B. R.; Westwell, A. D.; Stevens, M. F. G. J. Med. Chem. 2002, 45, 744-747.
http://dx.doi.org/10.1021/jm011025r
[14]. Palmer, F. J.; Trigg, R. B.; Warrington, J. V. J. Med. Chem. 1971, 14, 248-251.
http://dx.doi.org/10.1021/jm00285a022
[15]. Burger, A.; Sawhey, S. N. J. Med. Chem. 1968, 11, 270-273.
http://dx.doi.org/10.1021/jm00308a018
[16]. Chakole, R. D.; Amnerkar, N. D.; Khedekar, P. B.; Bhusari, K. P. Indian J. Heterocycl. Chem. 2005, 15, 27-30.
[17]. Jayachandran, E.; Bhatia, K.; Naragud, L. V. G.; Roy, A. Indian Drugs 2003, 40, 408-411.
[18]. Siddiqui, N.; Alam, M.; Siddiqui, A. A. Asian J. Chem. 2004, 16, 1005-1008.
[19]. Gurupadayya, B. M.; Gopal, M.; Padmashali, B.; Vaidya, V. P. Int. J. Heterocycl. Chem. 2005, 15, 169-172.
[20]. Diaz, H. M.; Molina, R. V.; Andrade, R. O.; Coutino, D. D; Franco, L. M.; Webster, S. P.; Binnie, M.; Soto, S. E.; Barajas, M. I.; Rivera, I. L; Vazquez, G. N. Bioorg. Med. Chem. Lett. 2008, 18, 2871-2877.
http://dx.doi.org/10.1016/j.bmcl.2008.03.086
[21]. Henriksen, G.; Hauser, A. I.; Westwell, A. D.; Yousefi, B. H.; Schwaiger, M.; Drzega, A.; Wester, H. J. J. Med. Chem. 2007, 50, 1087-1089.
http://dx.doi.org/10.1021/jm061466g
[22]. Mathis, C. A.; Wang, Y.; Holt, D. P.; Haung, G. F.; Debnath, M. L.; Klunk, W. E. J. Med. Chem. 2003, 46, 2740-2754.
http://dx.doi.org/10.1021/jm030026b
[23]. Wang, X.;Sarris, K.; Kage, K.; Zhang, D.;Brown, S. P.; Kolasa, T.; Surowy, C.; ElKouhen, O. F.; Muchmore, S. W.; Brioni, J. D.; Stewart, A. O. J. Med. Chem. 2009, 52, 170-180.
http://dx.doi.org/10.1021/jm801042a
[24]. Sgouras, D.; Maragkoudakis, P.; Petraki, K.; Martinez-Gonzalez, B.; Eriotou, E.; Michopoulos, S.; Kalantzopoulos, G.; Tsakalidou, E.; Mentis, A. Appl. Environ. Microbiol. 2004, 70, 518-526.
http://dx.doi.org/10.1128/AEM.70.1.518-526.2004
[25]. Wiart, C. Oxford. C. J. Med. 2007, 4, 299-311.
[26]. El-Zahar, M. I.; Abd EL-Karim, S. S.; Haiba, M. E. World J. Chem. 2009, 4, 182-194.
[27]. Hall, M. D.; Salam, N. K.; Hellawell, J. L.; Fales, H. M.; Kensler, C. B.; Ludwig, J. A.; Szakacs, G.; Hibbs, D. E.; Gottesman, M. M. J. Med. Chem. 2009, 52, 3191-3204.
http://dx.doi.org/10.1021/jm800861c
[28]. Amin, K. M.; El-Zahar, M. I.; Anwar, M. M.; Kamel, M. M.; Mohamed, M. H. Acta Poloniae Pharm. 2009, 66, 279-291.
[29]. Farghaly, A.; El-Kashef, H. Arkivoc 2006, 11, 76-90.
http://dx.doi.org/10.3998/ark.5550190.0007.b07
[30]. Bashwan, S. A.; Fayed, A. A.; Amer, A. A. Nat. Sci. 2010, 8, 86-91.
[31]. Andrews, J. M. J. Antimicrob. Chemother. 2001, 48, 5-16.
http://dx.doi.org/10.1093/jac/48.suppl_1.5
[32]. Khalifa, N. M.; Adel, A. H. A.; Sherein, I. A. E.; Omar, A. F.; Amina, A. A. E. Res. Chem. Intermed. 2015, 41, 2295-2305.
http://dx.doi.org/10.1007/s11164-013-1347-1
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DOI Link: https://doi.org/10.5155/eurjchem.6.2.98-106.1161
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European Journal of Chemistry 2015, 6(2), 98-106 | doi: https://doi.org/10.5155/eurjchem.6.2.98-106.1161 | Get rights and content
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