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Synthesis of novel cyanoacetamides derivatives and their urease inhibition studies
Abdul Rauf (1)
, Khalil Ahmed Nazish (2) , Faiz-ul Hassan Nasim (3) , Asma Yaqoob (4) , Ashfaq Mahmood Qureshi (5,*) (1) Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
(2) Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
(3) Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
(4) Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
(5) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(*) Corresponding Author
Received: 19 Nov 2014 | Revised: 06 Jan 2015 | Accepted: 18 Jan 2015 | Published: 30 Jun 2015 | Issue Date: June 2015
Abstract
The present study reports a convenient approach for the synthesis of cyanoacetamide based derivatives (7-27) via two-step process involving Knoevenagel reaction, followed by three component reaction to avail desired compounds. All the synthesized compounds were obtained in good to excellent yield and extensively characterized employing 1H NMR, 13C NMR, mass spectrometry and physical parameters. Further, these compounds were screened for urease inhibition. All of the synthesized compounds exhibited good to excellent urease activity notably compound 15 and 19 showed excellent urease inhibition activity with IC50 value ~17.34 μg/mL and 36.75 μg/mL in comparison to thiourea (used as standard) having IC50 value ~27.5 μg/mL.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.6.2.163-168.1224
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DOI Link: https://doi.org/10.5155/eurjchem.6.2.163-168.1224
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European Journal of Chemistry 2015, 6(2), 163-168 | doi: https://doi.org/10.5155/eurjchem.6.2.163-168.1224 | Get rights and content
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