European Journal of Chemistry

Synthesis of novel cyanoacetamides derivatives and their urease inhibition studies

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Published: Jun 30, 2015
DOI: https://doi.org/10.5155/eurjchem.6.2.163-168.1224
Keywords:
Furan, Thiophene, Cyanoactamides, Urease inhibition activity, Knoevenagel condensation, N, N-Dimethyl barbituric acid
Section
Research Article
Issue
Vol. 6 No. 2 (2015): June 2015
Dates
Received 2014-11-19
Accepted 2015-01-18
Published 2015-06-30


Main Article Content

Abdul Rauf
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
Khalil Ahmed Nazish
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
Faiz-ul Hassan Nasim
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
Asma Yaqoob
Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan
Ashfaq Mahmood Qureshi
Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan

Abstract

The present study reports a convenient approach for the synthesis of cyanoacetamide based derivatives (7-27) via two-step process involving Knoevenagel reaction, followed by three component reaction to avail desired compounds. All the synthesized compounds were obtained in good to excellent yield and extensively characterized employing 1H NMR, 13C NMR, mass spectrometry and physical parameters. Further, these compounds were screened for urease inhibition. All of the synthesized compounds exhibited good to excellent urease activity notably compound 15 and 19 showed excellent urease inhibition activity with IC50 value ~17.34 μg/mL and 36.75 μg/mL in comparison to thiourea (used as standard) having IC50 value ~27.5 μg/mL.


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(1)
Rauf, A.; Nazish, K. A.; Nasim, F.- ul H.; Yaqoob, A.; Qureshi, A. M. Synthesis of Novel Cyanoacetamides Derivatives and Their Urease Inhibition Studies. Eur. J. Chem. 2015, 6, 163-168.

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