European Journal of Chemistry 2015, 6(2), 189-198 | doi: https://doi.org/10.5155/eurjchem.6.2.189-198.1244 | Get rights and content

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Synthesis, spectral characterization, antimicrobial, DNA binding and antioxidant studies of Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of novel thiosalen analog N2S2


Sabry Hamed Seda (1) , Ayman Ahmed Abdel Aziz (2,*)

(1) Department of Chemistry, Faculty of Science, University of Tabuk, 71491, Tabuk, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Ain Shams University, Abassia, 11566, Cairo, Egypt
(*) Corresponding Author

Received: 18 Jan 2015 | Revised: 26 Feb 2015 | Accepted: 22 Mar 2015 | Published: 30 Jun 2015 | Issue Date: June 2015

Abstract


Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of a quadridentate Schiff base with a N2S2 donor set derived from condensation of benzene-1,2-dicarboxaldehyde(o-phthaldehyde) with 2-aminothiophenol were synthesized and characterized by elemental microanalyses, molar conductance, magnetic susceptibility measurements and spectroscopic techniques viz, FT-IR, 1H NMR, EPR and UV-Vis. The spectral data showed that, the ligand acts as a tetradentate ligand and the bonding sites were deprotonated thiol-S groups and azomethine nitrogen atoms. The results have indicated that the complexes exhibited tetrahedral geometry arrangements except Cu(II) complex that exhibited square planar geometry. Preliminary antimicrobial screening shows the promising results against both bacterial and fungal strains. The interaction of the Schiff base ligand and its complexes with calf-thymus DNA (CT-DNA) has been monitored by UV-Vis, competitive fluorescence titration and hydrodynamic techniques (Viscosity measurements). The results have indicated that the ligand and its complexes bind to CT-DNA through intercalation mode. Moreover, investigations of antioxidative properties showed that all the compounds have strong radical scavenging properties. The data have shown that, among all compounds, Cu(II) complex has exhibited better biological activity than other complexes and the parent ligand.


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European Journal of Chemistry

Keywords


DNA binding; N2S2 Schiff base; M(II) complexes; Antioxidant studies; Antimicrobial screening; Spectral characterization

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DOI: 10.5155/eurjchem.6.2.189-198.1244

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Funding information


Deanship of Scientific Research (DSR), Grant No: S-1435-0099, University of Tabuk, Tabuk, Saudi Arabia

Citations

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[1]. Ayman A. Abdel Aziz, Sabry H. Seda
Synthesis, Spectral Characterization, SEM, Antimicrobial, Antioxidative Activity Evaluation, DNA Binding and DNA Cleavage Investigation of Transition Metal(II) Complexes Derived from a tetradentate Schiff base bearing thiophene moiety
Journal of Fluorescence  27(3), 1051, 2017
DOI: 10.1007/s10895-017-2039-9
/

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How to cite


Seda, S.; Abdel Aziz, A. Eur. J. Chem. 2015, 6(2), 189-198. doi:10.5155/eurjchem.6.2.189-198.1244
Seda, S.; Abdel Aziz, A. Synthesis, spectral characterization, antimicrobial, DNA binding and antioxidant studies of Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of novel thiosalen analog N2S2. Eur. J. Chem. 2015, 6(2), 189-198. doi:10.5155/eurjchem.6.2.189-198.1244
Seda, S., & Abdel Aziz, A. (2015). Synthesis, spectral characterization, antimicrobial, DNA binding and antioxidant studies of Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of novel thiosalen analog N2S2. European Journal of Chemistry, 6(2), 189-198. doi:10.5155/eurjchem.6.2.189-198.1244
Seda, Sabry, & Ayman Ahmed Abdel Aziz. "Synthesis, spectral characterization, antimicrobial, DNA binding and antioxidant studies of Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of novel thiosalen analog N2S2." European Journal of Chemistry [Online], 6.2 (2015): 189-198. Web. 28 May. 2023
Seda, Sabry, AND Abdel Aziz, Ayman. "Synthesis, spectral characterization, antimicrobial, DNA binding and antioxidant studies of Co(II), Ni(II), Cu(II) and Zn(II) metal complexes of novel thiosalen analog N2S2" European Journal of Chemistry [Online], Volume 6 Number 2 (30 June 2015)

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