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Synthesis and optimization of methyl 5-acetyl-1,4-dihydro-2,6-dimethyl-4-(substituent benzylidene)pyridine-3-carboxylate
Rui Dong Liu (1)
, Jian Zhang (2,*) (1) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(2) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(*) Corresponding Author
Received: 27 May 2010 | Revised: 24 Feb 2011 | Accepted: 28 Oct 2010 | Published: 30 Sep 2011 | Issue Date: September 2011
Abstract
Two 1,4-dihydro-Hantzsch pyridine derivatives were synthesized by three steps. In the condensation step, the reaction time can be shortened to 1.5 h through using H2SO4-acetic anhydride system as a catalyst rather than the acetic acid-piperidine systemin the cyclization step, the reaction time was shortened from 20 h in ethanol to 15 h in polar aprotic solvent, and the yield of two products also was increased from 43.3% and 39.7% in traditional solvent to 93.2% and 90.1% in polar aprotic solvent.
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DOI: 10.5155/eurjchem.2.3.308-310.126
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South-Central University for Nationalities
Citations
[1]. Ling Jiang, Hongwei Yu
Enzymatic promiscuity: Escherichia coli BioH esterase-catalysed Aldol reaction and Knoevenagel reaction
Chemical Research in Chinese Universities 30(2), 289, 2014
DOI: 10.1007/s40242-014-3401-y
[2]. Hua Li, Deliang Zhang, Mengna Gao, Lumei Huang, Longguang Tang, Zijing Li, Xiaoyuan Chen, Xianzhong Zhang
Highly specific C–C bond cleavage induced FRET fluorescence for in vivo biological nitric oxide imaging
Chemical Science 8(3), 2199, 2017
DOI: 10.1039/C6SC04071C
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DOI Link: https://doi.org/10.5155/eurjchem.2.3.308-310.126
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European Journal of Chemistry 2011, 2(3), 308-310 | doi: https://doi.org/10.5155/eurjchem.2.3.308-310.126 | Get rights and content
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