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Synthesis and optimization of methyl 5-acetyl-1,4-dihydro-2,6-dimethyl-4-(substituent benzylidene)pyridine-3-carboxylate
Rui Dong Liu (1) , Jian Zhang (2,*)
(1) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(2) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(*) Corresponding Author
Received: 27 May 2010 | Revised: 24 Feb 2011 | Accepted: 28 Oct 2010 | Published: 30 Sep 2011 | Issue Date: September 2011
Two 1,4-dihydro-Hantzsch pyridine derivatives were synthesized by three steps. In the condensation step, the reaction time can be shortened to 1.5 h through using H2SO4-acetic anhydride system as a catalyst rather than the acetic acid-piperidine systemin the cyclization step, the reaction time was shortened from 20 h in ethanol to 15 h in polar aprotic solvent, and the yield of two products also was increased from 43.3% and 39.7% in traditional solvent to 93.2% and 90.1% in polar aprotic solvent.
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European Journal of Chemistry
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. Satish, K.; Poonam, S.; Kamal, K. Tetrahedron 2008, 64, 536-538.
. Javid, S. M.; Mojarrad, V. D.; Carlos, V.; Edward, E. K. Bioorg. Med. Chem. Lett. 2005, 13, 4085-4091.
. Muchchinatala, M.; Vidavalur, S.; Yerra, K. R. J Mol. Catal. A: Chem. 2006, 260, 179-180.
. Churchil, A. A.; Kannan, S. Appl. Catal. A: General 2008, 338, 121-125.
. Shi, D. Q.; Mou, J.; Tu, S. J. Chinese J. Org. Chem. 2004, 24, 1042-1044.
. Saikat, D. S.; Parasa, H.; Dllip, K. Catal. Commun. 2008, 9, 709-714.
. Zhang, B. L.; He, W.; Shi, X.; Huan, M. L.; Huang, Q. J. Bioorg. Med. Chem. Lett. 2010, 20, 805-806.
. Deng, L.; Xu, M. X. Chem. Res. Appl. 2002, 14, 233-234.
. Lin, C. Z.; Ko, S. K. Tetrahedron Lett. 2005, 46, 5771-5774.
. Zhang, X. Y.; Li, Y. Z.; Fan, X. S.; Qu, G. R. Chinese Chem. Lett. 2006, 17, 150-152.
. Amini, M. A.; Golabchifar. A.; Dehpour A. R. Drug Res. 2002, 52, 21-26.
. Dondoni, A.; Massi, A.; Minghini, E.; Bertolasi, V. Tetrahedron 2004, 60, 2311-2326.
. Liu, H. C.; Feng, Y. Q. Chem. Ind. Eng. 2006, 23, 88-91.
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DOI Link: https://doi.org/10.5155/eurjchem.2.3.308-310.126
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European Journal of Chemistry 2011, 2(3), 308-310 | doi: https://doi.org/10.5155/eurjchem.2.3.308-310.126 | Get rights and content
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