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Synthesis and optimization of methyl 5-acetyl-1,4-dihydro-2,6-dimethyl-4-(substituent benzylidene)pyridine-3-carboxylate
Rui Dong Liu (1) , Jian Zhang (2,*)
(1) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(2) College of Chemistry and Materials, South-Central University for Nationalities, Wuhan, 430074, China
(*) Corresponding Author
Received: 27 May 2010 | Revised: 24 Feb 2011 | Accepted: 28 Oct 2010 | Published: 30 Sep 2011 | Issue Date: September 2011
Two 1,4-dihydro-Hantzsch pyridine derivatives were synthesized by three steps. In the condensation step, the reaction time can be shortened to 1.5 h through using H2SO4-acetic anhydride system as a catalyst rather than the acetic acid-piperidine systemin the cyclization step, the reaction time was shortened from 20 h in ethanol to 15 h in polar aprotic solvent, and the yield of two products also was increased from 43.3% and 39.7% in traditional solvent to 93.2% and 90.1% in polar aprotic solvent.
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DOI Link: https://doi.org/10.5155/eurjchem.2.3.308-310.126
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European Journal of Chemistry 2011, 2(3), 308-310 | doi: https://doi.org/10.5155/eurjchem.2.3.308-310.126 | Get rights and content
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