European Journal of Chemistry

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin



Main Article Content

Muhammad Islam
Zahid Shafiq
Mazhar Hussain
Hafiz Badaruddin Ahmad
Muhammad Ajaz Hussain

Abstract

Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.


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Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H. B.; Hussain, M. A. Synthesis, Characterization and Antimicrobial Studies of Imine Derivatives of Amoxicillin. Eur. J. Chem. 2015, 6, 417-421.

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Supporting Agencies

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800 Pakistan
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