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Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin
Muhammad Islam (1)
, Zahid Shafiq (2,*) , Mazhar Hussain (3) , Hafiz Badaruddin Ahmad (4) , Muhammad Ajaz Hussain (5) (1) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(2) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(3) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(4) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(5) Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
(*) Corresponding Author
Received: 13 Aug 2015 | Revised: 18 Sep 2015 | Accepted: 19 Sep 2015 | Published: 31 Dec 2015 | Issue Date: December 2015
Abstract
Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.
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DOI: 10.5155/eurjchem.6.4.417-421.1310
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Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800 Pakistan
Citations
[1]. Qamar-un-Nisa Tariq, Sana Malik, Ajmal Khan, Muhammad Moazzam Naseer, Shafi Ullah Khan, Abida Ashraf, Muhammad Ashraf, Muhammad Rafiq, Khalid Mahmood, Muhammad Nawaz Tahir, Zahid Shafiq
Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies
Bioorganic Chemistry 84, 372, 2019
DOI: 10.1016/j.bioorg.2018.11.053
[2]. Ramgopal Appani, Baburao Bhukya, Kiran Gangarapu
Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one
Scientifica 2016, 1, 2016
DOI: 10.1155/2016/1249201
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DOI Link: https://doi.org/10.5155/eurjchem.6.4.417-421.1310
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European Journal of Chemistry 2015, 6(4), 417-421 | doi: https://doi.org/10.5155/eurjchem.6.4.417-421.1310 | Get rights and content
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