European Journal of Chemistry 2015, 6(4), 417-421 | doi: https://doi.org/10.5155/eurjchem.6.4.417-421.1310 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin


Muhammad Islam (1) , Zahid Shafiq (2,*) , Mazhar Hussain (3) , Hafiz Badaruddin Ahmad (4) , Muhammad Ajaz Hussain (5)

(1) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(2) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(3) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(4) Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan
(5) Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan
(*) Corresponding Author

Received: 13 Aug 2015 | Revised: 18 Sep 2015 | Accepted: 19 Sep 2015 | Published: 31 Dec 2015 | Issue Date: December 2015

Abstract


Some novel imine derivatives (1-14) of a broad spectrum antibiotic amoxicillin were prepared by condensation with different carbonyl compounds. The amoxicillin imine derivatives were characterized using elemental analysis and spectroscopic techniques such as FT-IR and 1H NMR. The prepared imine derivatives were evaluated for antimicrobial activities against some pathogens using disc diffusion method. The results of present studies demonstrate enhanced antimicrobial activity of the novel imine derivatives of amoxicillin as compared to the parent drug.


Announcements


Our editors have decided to support scientists to publish their manuscripts in European Journal of Chemistry without any financial constraints.

1- The article processing fee will not be charged from the articles containing the single-crystal structure characterization or a DFT study between September 15, 2023 and October 31, 2023 (Voucher code: FALL2023).

2. A 50% discount will be applied to the article processing fee for submissions made between September 15, 2023 and October 31, 2023 by authors who have at least one publication in the European Journal of Chemistry (Voucher code: AUTHOR-3-2023).

3. Young writers will not be charged for the article processing fee between September 15, 2023 and October 31, 2023 (Voucher code: YOUNG2023).


Editor-in-Chief
European Journal of Chemistry

Keywords


Antibiotics; Amoxicillin; Schiff’s base; Condensation; Imine derivatives; Antimicrobial activity

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.6.4.417-421.1310

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1972 times | icon graph PDF Article downloaded 772 times

Funding information


Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800 Pakistan

Citations

/


[1]. Qamar-un-Nisa Tariq, Sana Malik, Ajmal Khan, Muhammad Moazzam Naseer, Shafi Ullah Khan, Abida Ashraf, Muhammad Ashraf, Muhammad Rafiq, Khalid Mahmood, Muhammad Nawaz Tahir, Zahid Shafiq
Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies
Bioorganic Chemistry  84, 372, 2019
DOI: 10.1016/j.bioorg.2018.11.053
/


[2]. Ramgopal Appani, Baburao Bhukya, Kiran Gangarapu
Synthesis and Antibacterial Activity of 3-(Substituted)-2-(4-oxo-2-phenylquinazolin-3(4H)-ylamino)quinazolin-4(3H)-one
Scientifica  2016, 1, 2016
DOI: 10.1155/2016/1249201
/


References


[1]. Hay, S. I.; Battle, K. E.; Pigott, D. M.; Smith, D. L.; Moyes, C. L.; Bhatt, S.; Brownstein, J. S.; Collier, N.; Myers, M. F.; George, D. B.; Gething, P. W. Trans. R. Soc. Lond. B: Biol. Sci. 2013, 368, 20120250, 1-11.

[2]. Aoki, H.; Okuhara, M. Annu. Rev. Microbiol. 1980, 34, 159-181.
http://dx.doi.org/10.1146/annurev.mi.34.100180.001111

[3]. Kemal, U.; Palabiyik, L.; Karacan, E.; Feyyaz, O. Turk J. Pharm. Sci. 2008, 5, 1-16.

[4]. Qin, W.; Panunzio, M.; Biondi, S. Antibiotics 2014, 3, 193-215.
http://dx.doi.org/10.3390/antibiotics3020193

[5]. Utsui, Y.; Inoue, M.; Mitsuhashi, S. Antimicrob. Agents Chemother. 1987, 31, 1085-1092.
http://dx.doi.org/10.1128/AAC.31.7.1085

[6]. Sanders, C. C.; Sanders, W. E. Clin. Infect. Dis. 1992, 15, 824-839.
http://dx.doi.org/10.1093/clind/15.5.824

[7]. Leemans, E.; Fisher, J.; Mobashery, S.; Marinelli, F.; Genilloud, O. Eds.; Springer Berlin Heidelberg, 2014; pp 59-84.

[8]. Acuna, C.; Rabasseda, X. Drugs Today 2001, 37, 193-210.
http://dx.doi.org/10.1358/dot.2001.37.3.614856

[9]. Kaur, S. P.; Rao, R.; Nanda, S. Int. J. Pharm. Pharm. Sci. 2011, 3, 30-37.

[10]. Nazir, F.; Bukhari, I. H.; Arif, M.; Riaz, M.; Naqvi, S. A. R.; Bokhari, T. H.; Jamal, M. A. Int. J. Curr. Pharm. Res. 2013, 5, 40-47.

[11]. Bijev, A. T.; Hung, V. Arzneimitt. Forsch. 2001, 51, 667-672.

[12]. Tomi, I. H. R.; Abdullah, A. H.; Al-Daraji, A. H. R.; Abbass, S. A. R. Eur. J. Chem. 2013, 4(2), 153-156.
http://dx.doi.org/10.5155/eurjchem.4.2.153-156.751

[13]. Joshi, S. Int. J. Pharm. Biol. Sci. 2011, 2, 240-250.

[14]. Joshi, S.; Pawar, V.; Uma, V. Res. J. Pharm. Biol. Chem. Sci. 2011, 2, 61-70.

[15]. Al-Noor, T. H.; Aziz, M. R.; AL-Jeboori, A. T. J. Chem. Pharm. Res. 2014, 6, 1225-1231.

[16]. Abdel-Rahman, A. A. H.; Abdel-Megied, A. E. -S.; Hawata, M. A. A.; Kasem, E. R.; Shabanm, M. T. Monatsh. Chem. 2007, 138, 889-897.
http://dx.doi.org/10.1007/s00706-007-0700-8

[17]. Azevedo, C. M. P. G., PhD Thesis, 2012, http://hdl. handle.net/10216 /73974

[18]. Hameed, A.; Shafiq, Z.; Yaqub, M.; Hussain, M.; Hussain, M. A.; Afzal, M.; Tahir, M. N.; Naseer, M. M. New J. Chem. 2015, DOI: 10.1039/C5NJ01879J.
http://dx.doi.org/10.1039/C5NJ01879J

[19]. Chohan, Z. H.; Arif, M.; Shafiq, Z.; Yaqub, M.; Supuran, C. T. J. Enzyme Inhib. Med. Chem. 2006, 21(1), 95-103.
http://dx.doi.org/10.1080/14756360500456806

[20]. Hussain A.; Shafiq, Z.; Tahir, M. N.; Yaqub, M. Acta Crytallog. E 2010, 66(8), o1888-o1888.

[21]. Hameed, A.; Khan, K. M.; Zehra, S. T.; Ahmed, R.; Shafiq, Z.; Bakht, S. M.; Yaqub, M.; Hussain, M.; de Leon, A. de la V.; Furtmann, N.; Bajorath, J.; Shad, H. A.; Tahir, M. N.; Iqbal, J. Bioorg. Chem. 2015, 61, 51-57.
http://dx.doi.org/10.1016/j.bioorg.2015.06.004

[22]. Jodeh, S.; Stati, H.; Haddad, M.; Renno, T.; Zaid, A.; Jaradat, N.; Kharoaf, M. Eur. J. Chem. 2012, 3(4), 480‐484.
http://dx.doi.org/10.5155/eurjchem.3.4.480-484.698

[23]. El‐Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2(4), 539‐543.
http://dx.doi.org/10.5155/eurjchem.2.4.539-543.55


How to cite


Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H.; Hussain, M. Eur. J. Chem. 2015, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, M.; Shafiq, Z.; Hussain, M.; Ahmad, H.; Hussain, M. Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin. Eur. J. Chem. 2015, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, M., Shafiq, Z., Hussain, M., Ahmad, H., & Hussain, M. (2015). Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin. European Journal of Chemistry, 6(4), 417-421. doi:10.5155/eurjchem.6.4.417-421.1310
Islam, Muhammad, Zahid Shafiq, Mazhar Hussain, Hafiz Badaruddin Ahmad, & Muhammad Ajaz Hussain. "Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin." European Journal of Chemistry [Online], 6.4 (2015): 417-421. Web. 3 Oct. 2023
Islam, Muhammad, Shafiq, Zahid, Hussain, Mazhar, Ahmad, Hafiz, AND Hussain, Muhammad. "Synthesis, characterization and antimicrobial studies of imine derivatives of amoxicillin" European Journal of Chemistry [Online], Volume 6 Number 4 (31 December 2015)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.6.4.417-421.1310


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2015, 6(4), 417-421 | doi: https://doi.org/10.5155/eurjchem.6.4.417-421.1310 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.