

Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety
Monther Faisal Mahdi (1,*)



(1) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(2) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(3) Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
(*) Corresponding Author
Received: 13 Oct 2015 | Revised: 06 Nov 2015 | Accepted: 14 Nov 2015 | Published: 31 Mar 2016 | Issue Date: March 2016
Abstract
An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and 1H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.7.1.8-13.1333
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Al Mustansiriyah Pharmacy College in Baghdad, Iraq
Citations
[1]. Kashif Haider, Neelima Shrivastava, Ankita Pathak, Rikeshwer Prasad Dewangan, Shaikh Yahya, M. Shahar Yar
Recent advances and SAR study of 2-substituted benzothiazole scaffold based potent chemotherapeutic agents
Results in Chemistry 4, 100258, 2022
DOI: 10.1016/j.rechem.2021.100258

[2]. Milad Edraki, Davood Zaarei
Azole derivatives embedded in montmorillonite clay nanocarriers as corrosion inhibitors of mild steel
International Journal of Minerals, Metallurgy, and Materials 26(1), 86, 2019
DOI: 10.1007/s12613-019-1712-1

[3]. Larisa V. Zhilitskaya, Bagrat A. Shainyan, Nina O. Yarosh
Modern Approaches to the Synthesis and Transformations of Practically Valuable Benzothiazole Derivatives
Molecules 26(8), 2190, 2021
DOI: 10.3390/molecules26082190

[4]. Ming Jun Cen, Yu Wang, Yong Wu He
Microwave assistant synthesis of trans-4-nitrostilbene derivatives in solvent free condition
European Journal of Chemistry 8(1), 13, 2017
DOI: 10.5155/eurjchem.8.1.13-14.1525

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