Synthesis, characterization and antibacterial evaluation of novel  2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety

Monther Faisal Mahdi; Rafah Fadhil Al-Smaism; Noor Waleed Ibrahim

doi:10.5155/eurjchem.7.1.8-13.1333

European Journal of Chemistry 2016, 7(1), 8-13 | doi: https://doi.org/10.5155/eurjchem.7.1.8-13.1333 | Get rights and content

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Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety

Monther Faisal Mahdi ^(1,*)

, Rafah Fadhil Al-Smaism ⁽²⁾

, Noor Waleed Ibrahim ⁽³⁾

⁽¹⁾ Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
⁽²⁾ Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
⁽³⁾ Department of Pharmaceutical Chemistry, College of Pharmacy, Al-Mustansiriyah University, Baghdad, 10001, Iraq
^(*) Corresponding Author

Received: 13 Oct 2015 | Revised: 06 Nov 2015 | Accepted: 14 Nov 2015 | Published: 31 Mar 2016 | Issue Date: March 2016

Abstract

An efficient methods has been described for the synthesis of new 2-aminonicotinonitrile derivatives (6a-f) bearing benzothiazole nucleus by solvent free microwave or ultrasound irradiation. The reaction proceeds via one-pot four-component by cyclo condensation reaction of heterocyclic methyl ketones (4a), malononitrile, ammonium acetate and aryl aldehydes. Chalcones intermediate and final compounds were also synthesized by conventional methods, the result confirms that microwave method showed higher yield and purity than conventional one. The synthesized compounds were characterized by FT-IR spectroscopy and ¹H NMR. Antibacterial activities of the synthesized compounds have been tested against four different types of bacteria; most of the tested compounds showed significant biological activities.

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European Journal of Chemistry

Keywords

2-MBT; Chalcones; Microwave; Malononitrile; Ultrasonic method; 2-Aminonicotinonitrile

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DOI: 10.5155/eurjchem.7.1.8-13.1333

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Al Mustansiriyah Pharmacy College in Baghdad, Iraq

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How to cite

Mahdi, M.; Al-Smaism, R.; Ibrahim, N. Eur. J. Chem. 2016, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333

Mahdi, M.; Al-Smaism, R.; Ibrahim, N. Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety. Eur. J. Chem. 2016, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333

Mahdi, M., Al-Smaism, R., & Ibrahim, N. (2016). Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety. European Journal of Chemistry, 7(1), 8-13. doi:10.5155/eurjchem.7.1.8-13.1333

Mahdi, Monther, Rafah Fadhil Al-Smaism, & Noor Waleed Ibrahim. "Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety." European Journal of Chemistry [Online], 7.1 (2016): 8-13. Web. 28 May. 2023

Mahdi, Monther, Al-Smaism, Rafah, AND Ibrahim, Noor. "Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

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