European Journal of Chemistry 2016, 7(1), 135-136 | doi: https://doi.org/10.5155/eurjchem.7.1.135-136.1360 | Get rights and content

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Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold


Sankar Chatterjee (1,*)

(1) Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA
(*) Corresponding Author

Received: 09 Nov 2015 | Revised: 07 Dec 2015 | Accepted: 13 Dec 2015 | Published: 31 Mar 2016 | Issue Date: March 2016

Abstract


A molecular scaffold containing a furanoquinoline motif that offered a unique molecular architecture for 5-hydroxytryptamine 6 receptor antagonism was generated by a multi-component cyclization reaction.


Keywords


CNS; 5-HT6; Antagonist; Benzazepine; Furanoquinoline; Cyclocondensation

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DOI: 10.5155/eurjchem.7.1.135-136.1360

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References


[1]. Benhamu, B.; Martiin-Fontecha, M.; Vazquez-Villa, H.; Pardo, L.; Lopez-Rodriguez, M. L. J. Med. Chem. 2014, 57, 7160-7181.
http://dx.doi.org/10.1021/jm5003952

[2]. Ramirez, M. J. Alzheimer's Res. Ther. 2013, 5(15), 1-8.

[3]. Wesolowska, A. Pharmacol. Rep. 2010, 62, 564-567.
http://dx.doi.org/10.1016/S1734-1140(10)70315-7

[4]. Ly, S.; Pishadari, B.; Lok, L. L.; Hajos, M.; Kocsis, B. ACS Chem. Neurosci. 2013, 4, 191-199.
http://dx.doi.org/10.1021/cn300184t

[5]. Rosse, G.; Schaffhauser, H. Curr. Top. Med. Chem. 2010, 10, 207-221.
http://dx.doi.org/10.2174/156802610790411036

[6]. Hostetler, G.; Dunn, D.; McKenna, B. A.; Kopec, K.; Chatterjee, S. Chem. Bio. Drug Des. 2014, 83, 149-153.
http://dx.doi.org/10.1111/cbdd.12240

[7]. Hostetler, G.; Dunn, D.; McKenna, B. A.; Kopec, K.; Chatterjee, S. Chem. Bio. Drug Des. 2014, 83, 666-669.
http://dx.doi.org/10.1111/cbdd.12279

[8]. Ravindranath, N.; Ramesh, C.; Reddy, M. R.; Das, B. A. Chem. Lett. 2003, 32, 222-223.
http://dx.doi.org/10.1246/cl.2003.222

[9]. DaSilva, B. H. S. T.; Martins, L. M.; Silva-Filho, L. C. Synlett. 2012, 23, 1973-1977.
http://dx.doi.org/10.1055/s-0032-1316587


How to cite


Chatterjee, S. Eur. J. Chem. 2016, 7(1), 135-136. doi:10.5155/eurjchem.7.1.135-136.1360
Chatterjee, S. Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold. Eur. J. Chem. 2016, 7(1), 135-136. doi:10.5155/eurjchem.7.1.135-136.1360
Chatterjee, S. (2016). Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold. European Journal of Chemistry, 7(1), 135-136. doi:10.5155/eurjchem.7.1.135-136.1360
Chatterjee, Sankar. "Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold." European Journal of Chemistry [Online], 7.1 (2016): 135-136. Web. 17 Jan. 2022
Chatterjee, Sankar. "Application of a multi-component cyclocondensation to develop a bioactive molecular scaffold" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

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European Journal of Chemistry 2016, 7(1), 135-136 | doi: https://doi.org/10.5155/eurjchem.7.1.135-136.1360 | Get rights and content

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