European Journal of Chemistry 2016, 7(1), 115-120 | doi: https://doi.org/10.5155/eurjchem.7.1.115-120.1387 | Get rights and content






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Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity


Abbas Washeel Salman (1,*) , Rosenani A. Haque (2)

(1) Department of Chemistry, College of Science, Wasit University, Kut, Wasit, 52010, Iraq
(2) The School of Chemical Sciences, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia
(*) Corresponding Author

Received: 20 Dec 2015 | Revised: 08 Jan 2016 | Accepted: 09 Jan 2016 | Published: 31 Mar 2016 | Issue Date: March 2016

Abstract


The synthesis and characterization of two Ag(I)- N-heterocyclic carbene complexes 3 and 4 of imidazole-based NHC proligands 1 and 2, respectively, are described. The findings revealed that the choice of the counter ions is crucial, which can lead to different supramolecular architectures. Complex 3 is a trinuclear, whereas its analogue complex 4 is mononuclear. Despite being structurally different entities, these complexes form cis-palladium-NHC complex 5 by trans-metallation method, which is a cis-platinum analogue. All the reported compounds 1-5 were tested for their anticancer activities, where compounds 2 and 3 found more potent than the rest.


Keywords


HCT 116; Anticancer; Ag(I) complexes; Pd(II) complexes; Trans-metallation; N-heterocyclic carbene

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DOI: 10.5155/eurjchem.7.1.115-120.1387

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Funding information


Universiti Sains Malaysia for the Research University Grant 1001/PKIMIA/843090, the short term grant (203/PKIMIA/6311123) and the Research University grant 1001/PKIMIA/811217.

Citations

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[1]. Sunusi Y. Hussaini, Rosenani A. Haque, Tabinda Fatima, M. Taleb Agha, A. M. S. Abdul Majid, Mohd. R. Razali
Palladium(II) N-heterocyclic carbene complexes: synthesis, structures and cytotoxicity potential studies against breast cancer cell line
Journal of Coordination Chemistry  71(16-18), 2787, 2018
DOI: 10.1080/00958972.2018.1485901
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[2]. Wukun Liu, Ronald Gust
Update on metal N-heterocyclic carbene complexes as potential anti-tumor metallodrugs
Coordination Chemistry Reviews  329, 191, 2016
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[3]. Sunusi Y. Hussaini, Rosenani A. Haque, Mohd R. Razali
Recent progress in silver(I)-, gold(I)/(III)- and palladium(II)-N-heterocyclic carbene complexes: A review towards biological perspectives
Journal of Organometallic Chemistry  882, 96, 2019
DOI: 10.1016/j.jorganchem.2019.01.003
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Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Salman, A.; Haque, R. Eur. J. Chem. 2016, 7(1), 115-120. doi:10.5155/eurjchem.7.1.115-120.1387
Salman, A.; Haque, R. Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity. Eur. J. Chem. 2016, 7(1), 115-120. doi:10.5155/eurjchem.7.1.115-120.1387
Salman, A., & Haque, R. (2016). Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity. European Journal of Chemistry, 7(1), 115-120. doi:10.5155/eurjchem.7.1.115-120.1387
Salman, Abbas, & Rosenani A. Haque. "Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity." European Journal of Chemistry [Online], 7.1 (2016): 115-120. Web. 23 Jan. 2020
Salman, Abbas, AND Haque, Rosenani. "Pd(II) and trinuclear Ag(I) bis-N-heterocyclic carbene complexes: Synthesis, structural and in vitro anticancer activity" European Journal of Chemistry [Online], Volume 7 Number 1 (31 March 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.1.115-120.1387

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