European Journal of Chemistry

Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction

Main Article Content

Mohammed Abed Al-Hussein Salman
Nabeel Abed Abdul-Rida


A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.

icon graph This Abstract was viewed 2126 times | icon graph Article PDF downloaded 717 times

How to Cite
Salman, M. A. A.-H.; Abdul-Rida, N. A. Synthesis of New Derivatives of Aryl-Clonazepam via Suzuki Cross-Coupling Reaction. Eur. J. Chem. 2016, 7, 152-155.

Article Details

Crossref - Scopus - Google - European PMC

[1]. Ashton, C. H. Drugs 1994, 48, 25-40.

[2]. Baldwin, D.; Woods, R.; Lawson, R.; Taylor, D. Br. Med. J. 2011, 342, 1-11.

[3]. Manthey, L.; Van Veen, T.; Giltay, E. J.; Stoop, J. E., Neven, A. K.; Penninx, B. W. J. H., Zitman, F. G. Br. J. Clin. Pharmacol. 2011, 71, 263-272.

[4]. Lader, M. Br. J. Clin. Pharmacol. 2012, 77, 295-301.

[5]. Donoghue, J.; Lader, M. Int. J. Psychiatry Clin. Pract. 2010, 14, 78-87.

[6]. Varotto, M.; Roman, G.; Battistin, L. Boll. Soc. Ital. Biol. Sper. 1981, 57(8), 904-908.

[7]. Lehoullie, PF.; Ticku, MK. Eu. J. Pharmacol. 1987, 135, 235-238.

[8]. Griffin, C. E.; Kaye, A. M.; Bueno, F. R.; Kaye, A. D. Ochsner J. 2013, 13, 214-223.

[9]. Uddin, M. D.; Samanidou, V. F.; Papadoyannis, I. N. Pharmac. Anal. Acta. 2014, 5(6), 1-13.

[10]. Iqbal, M. M.; Sobhan, T.; Ryals, T. Psychiatr. Serv. 2002, 53, 39-40.

[11]. Cloos, J. M. Curr. Opin. Psychiatr. 2005, 18, 45-50.

[12]. Dresser, G. K.; Spence, J. D.; Bailey, D. G. Clin. Pharmacokinet. 2000, 38(1), 41–57.

[13]. Dourlat, J.; Liu, W. Q.; Gresh, N.; Garbay, C. Bioorg. Med. Chem. Lett. 2007, 17(9), 2527-2530.

[14]. Menezes, C. M. S.; Rivera, G.; Alves, M. A. Chem. Biol. Drug. Des. 2012, 79(6), 943-949.

[15]. Anwar, B.; Grimsey, P.; Hemming, K.; Krajniewskib, M.; Loukoua, C. Tetrahedron Lett. 2000, 41, 10107-10110.

[16]. Wood, M. R.; Kim, J. J.; Han, W. J. Med. Chem. 2003, 46, 1803-1806.

[17]. Butcher, J. W.; Liverton, N. J.; Claremon, D. A. Bioorg. Med. Chem. Lett. 2003, 13, 1165-1168.

[18]. Sherrill, R. G.; Berman, J. M.; Birkemo, L . Bioorg. Med. Chem. Lett. 2001, 11, 1145-1148.

[19]. Orrling, K. M.; Marzahn, M. R.; Teran, G. Bioorg. Med. Chem. 2009, 17, 5933-5949.

[20]. Cheng, P.; Zhang, Q.; Maa, Y.; Jiang, Z.; Zhang, X.; Zhang, F.; Chen, J. Bioorg. Med. Chem. Lett. 2008, 18, 3787-3789.

[21]. Owens, A. P.; Nadin, A.; Talbot, A. C.; Clarke, E. E.; Harrison, T.; Lewis, H. D.; Reilly, M.; Wrigley, J. D. J.; Castro, J. L. Bioorg. Med. Chem. Lett. 2003, 13, 4143-4145.

[22]. Nadin, A.; Lopez, J. M. S.; Owens, A. P.; Howells, D. M.; Talbot, A. C.; Harrison, T. J. Org. Chem. 2003, 68, 2844-2852.

[23]. Al-Soud, Y. A.; Al-Masoudi, N. A.; Al-Suod, H. H.; Pannecouquec, C. Z. Naturforsch. 2012, 67b, 925 – 934

[24]. Miyaura, N.; Suzuki, A. Chem. Rev. 1995, 95, 2457-2483.

[25]. Mahdi, K. M.; Abdul-Reda, N. A.; Al-Masoudi, N. A. Eur. J. Chem. 2015, 6 (1), 1‐7.

[26]. Al-Masoudi, N. A.; Kadhim, R. A.; Abdul-Rida, N. A.; Saeed, B. A.; Engel, M. Steroids 2015, 101, 43-50.

[27]. Abdul-Reda, N. A.; Kassim, A. G.; Al-Masoudi, N. A. Nucleos. Nucleot. Nucl. 2014, 33, 141-161.

[28]. Marich, Y. A.; Al-Salihi, N. J.; Al-Masoudi, N. A. Eur. J. Chem. 2014, 5(4), 588‐594.

[29]. Al-Masoudi, N. A.; Abdul-Rida, N. A.; Kadhim, R. A.; Krug, S. G.; Engel, M.; Saeed, B. A. Med. Chem. Res. 2016, 25, 310-321.

[30]. Davis, A. L.; Keeler, J.; Laue, E. D.; Moskau, D. J. Magn. Reson. 1992, 98, 207-216.

Supporting Agencies

Al-Qadisiyah University, 58002, Diwaniya, Iraq
Most read articles by the same author(s)

Dimensions - Altmetric - scite_ - PlumX

Downloads and views


Download data is not yet available.


Metrics Loading ...
License Terms

License Terms


Copyright © 2024 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License ( By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License ( are administered by Atlanta Publishing House LLC (European Journal of Chemistry).