European Journal of Chemistry

Synthesis of new derivatives of aryl-clonazepam via Suzuki Cross-coupling reaction



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Mohammed Abed Al-Hussein Salman
Nabeel Abed Abdul-Rida

Abstract

A new series of aryl clonazepam derivatives (11-16) have been synthesized by employing Suzuki Cross-coupling reaction, which includes the reaction of clonazepam with suitable derivative boronic acid at the presence of Pd(PPh3)4 as catalyst, and Na2CO3 as a base. The structures of the newly synthesized compounds were assigned by 1H, 13C and 2D NMR spectroscopic techniques.


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Salman, M. A. A.-H.; Abdul-Rida, N. A. Synthesis of New Derivatives of Aryl-Clonazepam via Suzuki Cross-Coupling Reaction. Eur. J. Chem. 2016, 7, 152-155.

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Al-Qadisiyah University, 58002, Diwaniya, Iraq
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