European Journal of Chemistry 2016, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410

Synthesis, characterization, physical and biological properties of some cholesterol derivatives


Nabeel Abed Abdul‐Reda (1,*) , Ahmed Kadhim Abass (2) , Noor Ali Gebur (3)

(1) Department of Chemistry, College of Education, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(2) Department of Chemistry, College of Science, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(3) Department of Chemistry, College of Science, Al-Qadisiyah University, Diwaniya, 58002, Al-Qadisiyah, Iraq
(*) Corresponding Author

Received: 10 Feb 2016, Accepted: 10 Apr 2016, Published: 30 Jun 2016

Abstract


A series of new cholesterol derivatives have been prepared via Mitsunobu reaction. The reaction was monitored by thin-layer chromatography (TLC) technique. All new compounds were characterized by melting points, elemental analysis, FT-IR, 1H, 13C and 2D-NMR spectroscopy. The antibacterial and antifungal activity of these derivatives was also determined. The phase transitions of the prepared derivatives were measured with the aid of differential scanning calorimetry. The textures of the mesophases have been determined with a hot stage equipped polarizing microscope, also the electrical conductivity of the solutions of these liquid crystals measured by electrical conductivity meter. The analysis showed that these prepared derivatives were liquid crystals.


Keywords


Steriods; Cholesterol; Liquid crystal; Thermal analysis; Mitsunobu reaction; Antimicrobial activity

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DOI: 10.5155/eurjchem.7.2.206-212.1410

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How to cite


Abdul‐Reda, N.; Abass, A.; Gebur, N. Eur. J. Chem. 2016, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, N.; Abass, A.; Gebur, N. Synthesis, characterization, physical and biological properties of some cholesterol derivatives. Eur. J. Chem. 2016, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, N., Abass, A., & Gebur, N. (2016). Synthesis, characterization, physical and biological properties of some cholesterol derivatives. European Journal of Chemistry, 7(2), 206-212. doi:10.5155/eurjchem.7.2.206-212.1410
Abdul‐Reda, Nabeel, Ahmed Kadhim Abass, & Noor Ali Gebur. "Synthesis, characterization, physical and biological properties of some cholesterol derivatives." European Journal of Chemistry [Online], 7.2 (2016): 206-212. Web. 21 Oct. 2019
Abdul‐Reda, Nabeel, Abass, Ahmed, AND Gebur, Noor. "Synthesis, characterization, physical and biological properties of some cholesterol derivatives" European Journal of Chemistry [Online], Volume 7 Number 2 (30 June 2016)

DOI Link: https://doi.org/10.5155/eurjchem.7.2.206-212.1410

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