European Journal of Chemistry

Recent advance in direct sp3 carbon-hydrogen bond functionalizations



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Xiao-Hua Cai
Jun Jin
Bing Xie

Abstract

Direct and selective carbon-hydrogen bond functionalization has attracted enormous attention because it provides more efficient strategies for preparing valuable functional molecules from easily available substrates. Significant and exciting developments in functionalization of un-activation Csp3-H bonds have continuously been made over the past few decades. This review mainly summarizes recent advances on direct Csp3-H bond functionalization for the formation of C-C and C-heteroatom bond under transition-metal-catalysed and metal-free conditions.


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Cai, X.-H.; Jin, J.; Xie, B. Recent Advance in Direct Sp3 Carbon-Hydrogen Bond Functionalizations. Eur. J. Chem. 2016, 7, 248-270.

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Supporting Agencies

The National Natural Science Foundation of China (21562016), the Natural Science Foundation of the Guizhou Science and Technology Depart-ment (JZ [2014]2010) and the Science and Technology Planing Project of Guiyang city [(2012204)23], China.
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