

ZnBr2-SiO2 catalyzed green synthesis of tetrazoles: Molecular docking and antioxidant activity studies
Chenna Krishna Reddy Reddivari (1)








(1) Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India
(2) Research and Development Centre, Micro Labs Ltd., Bangalore, 560100, India
(3) Department of Biotechnology, Sri Venkateswara University, Tirupati, 517502, India
(4) Department of Zoology, Sri Venkateswara University, Tirupati, 517502, India
(5) Department of Bio-Chemistry, Sri Venkateswara University, Tirupati, 517502, India
(6) Department of Zoology, Sri Venkateswara University, Tirupati, 517502, India
(7) Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India
(8) Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India
(*) Corresponding Author
Received: 09 Dec 2016 | Revised: 21 Jan 2017 | Accepted: 21 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017
Abstract
A series of 5-substituted and 1,5-disubstituted tetrazoles were synthesized in high yields from various biologically active substituted nitriles with sodium azide under heterogeneous catalysed (ZnBr2-SiO2) [2+3] cycloaddition conditions. This reaction gave an excellent yield in the presence of catalytic amount of 0.2 g of ZnBr2-SiO2, glycerol solvent system under microwave irradiation conditions. All the prepared compounds were characterized by elemental analysis 1H NMR, 13C NMR, FT-IR, and mass spectral data. The newly synthesized compounds were investigated for their respective molecular target using molecular docking studies. The results reveal that compounds 5a, 5c, 5e and 3e have conferred with multi target property. The compounds 5a, 5c and 5e have shown the highest binding affinities of -10.1, -9.7 and -10.6 with reverse transcriptase, -8.5, -8.2 and -8.9 with Aurora B, respectively. The compounds 5a, 5e and 3e have shown -8.9, -8.5 and 8.4 with Aromatase, respectively. In addition, the antioxidant activity data reveals that all the compounds showed good antioxidant activity, particularly the compounds 3d, 5d, and 5e exhibited promising radical scavenging activity.
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DOI: 10.5155/eurjchem.8.1.66-75.1515
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University Grants Commission (UGC) and Department of Chemistry, Sri Venkateswara University, Tirupati, 517502, India
Citations
[1]. Elena A. Popova, Rostislav E. Trifonov, Vladimir A. Ostrovskii
Tetrazoles for biomedicine
Russian Chemical Reviews 88(6), 644, 2019
DOI: 10.1070/RCR4864

[2]. Israel Niño‐Pantoja, Arturo Gallardo‐Alfonzo, Melchor Solis‐Santos, Mario Ordoñez, Claudia Contreras‐Celedón, Alejandro Islas‐Jácome, Luis Chacón‐García, Carlos J. Cortés‐García
Synthesis of 1,5‐Disubstituted Tetrazole−Indolizine Bis‐Heterocycles and Their Copper (II) Recognizing Properties
European Journal of Organic Chemistry 2022(34), , 2022
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[3]. Suman Majee, Shilpa, Mansi Sarav, Bimal Krishna Banik, Devalina Ray
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Pharmaceuticals 16(6), 873, 2023
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