European Journal of Chemistry 2017, 8(1), 42-45. doi:10.5155/eurjchem.8.1.42-45.1519

One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives


Yellanki Jagannadham (1) , Bhoomireddy Ramadevi (2) , Bethanamudi Prasanna (3,*)

(1) Research Center, Department of Chemistry, Chaitanya Post Graduate College (Autonomous), Hanamkonda, Warangal, 506001, India
(2) College of Engineering, Jawaharlal Nehru Technological University, Hyderabad, 500085, India
(3) Research Center, Department of Chemistry, Chaitanya Post Graduate College (Autonomous), Hanamkonda, Warangal, 506001, India
(*) Corresponding Author

Received: 15 Dec 2016, Accepted: 21 Jan 2017, Published: 31 Mar 2017

Abstract


The title compounds, substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-ones were obtained by reacting 3-aryl-1-(3-coumarinyl)propen-1-ones with 2-napthol catalyzed by DBU (1,8-diazabicyclo[5,4,0]undec-7-ene) and concentrated H2SO4 in ample yields. Their structures were characterized by IR, 1H NMR, 13C NMR, mass spectral and elemental analysis. All the synthesized compounds have been evaluated for their in-vitro antibacterial activity against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and antifungal activity against Aspergillus Niger and Candida albicans by using serial broth dilution method. Among those compounds 3 band 3c exhibits prominent results.


Keywords


DBU; Coumarins; Sulfuric acid; Cinnamoyl chromens; Antimicrobial activity; Hydroxyl naphthalene

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DOI: 10.5155/eurjchem.8.1.42-45.1519

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How to cite


Jagannadham, Y.; Ramadevi, B.; Prasanna, B. Eur. J. Chem. 2017, 8(1), 42-45. doi:10.5155/eurjchem.8.1.42-45.1519
Jagannadham, Y.; Ramadevi, B.; Prasanna, B. One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives. Eur. J. Chem. 2017, 8(1), 42-45. doi:10.5155/eurjchem.8.1.42-45.1519
Jagannadham, Y., Ramadevi, B., & Prasanna, B. (2017). One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives. European Journal of Chemistry, 8(1), 42-45. doi:10.5155/eurjchem.8.1.42-45.1519
Jagannadham, Yellanki, Bhoomireddy Ramadevi, & Bethanamudi Prasanna. "One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives." European Journal of Chemistry [Online], 8.1 (2017): 42-45. Web. 20 Nov. 2019
Jagannadham, Yellanki, Ramadevi, Bhoomireddy, AND Prasanna, Bethanamudi. "One pot synthesis of substituted 1H-benzo[f]chromen-3-yl-2H-chromen-2-one derivatives" European Journal of Chemistry [Online], Volume 8 Number 1 (31 March 2017)

DOI Link: https://doi.org/10.5155/eurjchem.8.1.42-45.1519

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