European Journal of Chemistry

Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity



Main Article Content

Rohini Narayan Shelke
Dattatraya Navnath Pansare
Chandrakant Dhondiram Pawar
Arun Khandu Deshmukh
Rajendra Pandu Pawar
Saroj Ram Bembalkar

Abstract

Microwave assisted and conventional synthetic methods of new 6-bromo-2-(substituted)-3H-imidazo[4,5-b]pyridine and its derivatives are described, which were obtained in reduced reaction times, higher yields, cleaner reactions than previously described methods. All the synthesized compounds were characterized, and screened for their anticancer and antimicrobial activity. Among synthesized compounds 3b and 3k shows prominent antibacterial activity and compound 3f shows both antibacterial and antifungal activity. Compounds 3h and 3j shows prominent anticancer activity against the both breast cancer cell lines, MCF-7 and BT-474. These results suggest that the imidazo[4,5-b]pyridine moiety may serve as a new promising template for synthesis of anticancer and antimicrobial agents and further study is required for evaluation of their mechanism of action.


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Shelke, R. N.; Pansare, D. N.; Pawar, C. D.; Deshmukh, A. K.; Pawar, R. P.; Bembalkar, S. R. Synthesis of 3H-imidazo[4,5-B] Pyridine With Evaluation of Their Anticancer and Antimicrobial Activity. Eur. J. Chem. 2017, 8, 25-32.

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Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India
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