European Journal of Chemistry 2017, 8(1), 25-32 | doi: https://doi.org/10.5155/eurjchem.8.1.25-32.1522 | Get rights and content

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Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity


Rohini Narayan Shelke (1,*) , Dattatraya Navnath Pansare (2) , Chandrakant Dhondiram Pawar (3) , Arun Khandu Deshmukh (4) , Rajendra Pandu Pawar (5) , Saroj Ram Bembalkar (6)

(1) Department of Chemistry, Deogiri College, Aurangabad, 431005, India
(2) Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, India
(3) Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, India
(4) Rao Bahadhur Narayanrao Borawake College Shrirampur, Ahmednagar, 413709, India
(5) Department of Chemistry, Deogiri College, Aurangabad, 431005, India
(6) Department of Chemistry, Deogiri College, Aurangabad, 431005, India
(*) Corresponding Author

Received: 20 Dec 2016 | Accepted: 15 Jan 2017 | Published: 31 Mar 2017 | Issue Date: March 2017

Abstract


Microwave assisted and conventional synthetic methods of new 6-bromo-2-(substituted)-3H-imidazo[4,5-b]pyridine and its derivatives are described, which were obtained in reduced reaction times, higher yields, cleaner reactions than previously described methods. All the synthesized compounds were characterized, and screened for their anticancer and antimicrobial activity. Among synthesized compounds 3b and 3k shows prominent antibacterial activity and compound 3f shows both antibacterial and antifungal activity. Compounds 3h and 3j shows prominent anticancer activity against the both breast cancer cell lines, MCF-7 and BT-474. These results suggest that the imidazo[4,5-b]pyridine moiety may serve as a new promising template for synthesis of anticancer and antimicrobial agents and further study is required for evaluation of their mechanism of action.


Keywords


Anticancer activity; Substituted aldehydes; Antimicrobial activity; Conventional synthesis; Microwave-assisted synthesis; 5-Bromopyridine-2,3-diamine

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DOI: 10.5155/eurjchem.8.1.25-32.1522

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Funding information


Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India

Citations

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[1]. Sülünay Parlar, Yalçın Erzurumlu, Recep Ilhan, Petek Ballar Kırmızıbayrak, Vildan Alptüzün, Ercin Erciyas
Synthesis and evaluation of pyridinium-hydrazone derivatives as potential antitumoral agents
Chemical Biology & Drug Design  92(1), 1198, 2018
DOI: 10.1111/cbdd.13177
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How to cite


Shelke, R.; Pansare, D.; Pawar, C.; Deshmukh, A.; Pawar, R.; Bembalkar, S. Eur. J. Chem. 2017, 8(1), 25-32. doi:10.5155/eurjchem.8.1.25-32.1522
Shelke, R.; Pansare, D.; Pawar, C.; Deshmukh, A.; Pawar, R.; Bembalkar, S. Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity. Eur. J. Chem. 2017, 8(1), 25-32. doi:10.5155/eurjchem.8.1.25-32.1522
Shelke, R., Pansare, D., Pawar, C., Deshmukh, A., Pawar, R., & Bembalkar, S. (2017). Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity. European Journal of Chemistry, 8(1), 25-32. doi:10.5155/eurjchem.8.1.25-32.1522
Shelke, Rohini, Dattatraya Navnath Pansare, Chandrakant Dhondiram Pawar, Arun Khandu Deshmukh, Rajendra Pandu Pawar, & Saroj Ram Bembalkar. "Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity." European Journal of Chemistry [Online], 8.1 (2017): 25-32. Web. 16 Jan. 2021
Shelke, Rohini, Pansare, Dattatraya, Pawar, Chandrakant, Deshmukh, Arun, Pawar, Rajendra, AND Bembalkar, Saroj. "Synthesis of 3H-imidazo[4,5-b] pyridine with evaluation of their anticancer and antimicrobial activity" European Journal of Chemistry [Online], Volume 8 Number 1 (31 March 2017)

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European Journal of Chemistry 2017, 8(1), 25-32 | doi: https://doi.org/10.5155/eurjchem.8.1.25-32.1522 | Get rights and content

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