European Journal of Chemistry

Synthesis and antimicrobial activity of 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane

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Published: Mar 31, 2017
DOI: https://doi.org/10.5155/eurjchem.8.1.82-84.1537
Keywords:
Formalin, Synthesis, n-Butylamine, 4-Iodoaniline, Triazacyclohexane, Antibacterial activity
Section
Research Article
Issue
Vol. 8 No. 1 (2017): March 2017
Dates
Received 2016-12-30
Accepted 2017-01-22
Published 2017-03-31


Main Article Content

Leila Lefrada
Laboratory of Applied Chemistry and Materials Technology University Larbi Ben M’hidi of Oum El Bouaghi, 04000, Algeria
Randolf Köhn
Department of Chemistry University of Bath, Bath, BA2 7AY, United Kingdom
Souhila Malki
Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
Wissam Mazouz
Department of Biology, Faculty of Sciences, University Badji Mokhtar, 2300 Annaba, Algeria
Ahcene Bouchemma
Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria
Meriem Hadjem
Faculty of Exact Sciences, Department of Material Science, University Larbi Ben M’hidi of Oum El Bouaghi, Rue de Constantine, 04000, Algeria

Abstract

This work describes the synthesis, structural characterization and antibacterial activities of 1,3,5-triazacyclohexane type of new compound 1,3-bis-butyl-5-(4-iodophenyl)-1,3,5-triazacyclohexane. The new triazacyclohexanes (R3TAC) with mixed aryl and alkyl N-substituents are synthesized by the reaction of a 1:2 mixture of 4-iodoaniline and n-butylamine with formalin. The synthesized compounds were characterized by spectral analysis IR, 1H NMR and 13C NMR. The compound was screened for it’s antibacterial activity against Gram-positive and Gram-negative bacteria by the diffusion method on agar medium.


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How to Cite
(1)
Lefrada, L.; Köhn, R.; Malki, S.; Mazouz, W.; Bouchemma, A.; Hadjem, M. Synthesis and Antimicrobial Activity of 1,3-Bis-Butyl-5-(4-Iodophenyl)-1,3,5-Triazacyclohexane. Eur. J. Chem. 2017, 8, 82-84.

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Author Biography

Leila Lefrada, Laboratory of Applied Chemistry and Materials Technology University Larbi Ben M’hidi of Oum El Bouaghi, 04000, Algeria


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References

[1]. Franchimont, A. P. N.; Erp, H. Rec. Trav. Chim. 1896, 15, 66-68.
https://doi.org/10.1002/recl.18960150204

[2]. Miller, J. G.; Wagner, E. C. J. Am. Chem. Soc. 1932, 54, 3698-3706.
https://doi.org/10.1021/ja01348a030

[3]. Baker, M. V.; Palermo, M. C.; Skelton, B. W.; White, A. H. ACS Catal. 2016, 6, 3008-3016.
https://doi.org/10.1021/acscatal.6b00542

[4]. Guido. S. PhD thesis, Technischen Universitat, Berlin, 1999.

[5]. Bouchemma, A.; McCabe, P. H.; Sim, G. A. J. Chem. Soc., Perkin Trans. 2 1989, 6, 583-587.
https://doi.org/10.1039/p29890000583

[6]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4676-o4678.
https://doi.org/10.1107/S1600536806030601

[7]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4674-o4675.
https://doi.org/10.1107/S160053680603546X

[8]. Latreche, S.; Bouchemma, A.; Bouacida S.; Bouhenguel M.; Mousser, A. Acta Cryst. E 2006, 62, o4960-o4962.
https://doi.org/10.1107/S160053680604147X

[9]. Khalaj, A.; Nakhjiri, M.; Negahbani, A. S.; Samadizadeh, M.; Firoozpour, L, Rajabalian, S.; Samadi, N.; Faramarzi, M. A.; Dibpour, N. A.; Shafiee, A.; Foroumadi, A. Eur. J. Med. Chem. 2011, 46, 65-70.
https://doi.org/10.1016/j.ejmech.2010.10.015

[10]. Pinkner, J. S.; Remaut, H.; Buelens, F.; Miller, E.; Aberg, V.; Pemberton, N.; Hedenstrom, M.; Larsson, A.; Seed, P.; Waksman, G.; Hultgren, S. J.; Almqvist, F. Natl. Acad. Sci. U. S. A. 2006, 103, 17897-17900.
https://doi.org/10.1073/pnas.0606795103

[11]. Meka, V. G.; Pillai, S. K.; Sakoulas, G.; Wennersten, C.; Venkataraman, L.; DeGirolami, P. C.; Eliopoulos, G. M.; Moellering, R. C.; Gold H. S. J. Infect. Dis. Drug. Targets 2004, 190, 311-317.

[12]. Chebbah, M.; Messai, A.; Bilge, D.; Bouchemma, A.; Parlak. C. J. Mol. Struc. 2017, 1129, 152-159.
https://doi.org/10.1016/j.molstruc.2016.09.060

[13]. Lefrada, L.; Bouchemma, A.; Bouhenguel, M.; Ferhati, A.; Chebbah, M. Eur. J. Chem. 2012, 3(4), 404-405.
https://doi.org/10.5155/eurjchem.3.4.404-405.657

[14]. Malki, S.; Lefrada, L.; Bouchemma, A.; Bouhenguel, M.; Chebbah, M.; Sid, A. Eur. J. Chem. 2016, 7(1), 137-138.
https://doi.org/10.5155/eurjchem.7.1.137-138.1337

[15]. Ferhati, A.; Bouchemma, A.; Bouhenguel, M.; Lefrada, L.; Assia, S. Eur. J. Chem. 2017, 8(1), 18-19.
https://doi.org/10.5155/eurjchem.8.1.18-19.1510

[16]. Ponce, A. G.; Fritz, R.; Valle, C.; Roura, S. I. Food Science. 2003, 36, 679-684.

Supporting Agencies

Laboratory of Applied Chemistry and Materials Technology of the University Larbi Ben M’hidi of Oum El Bouaghi, Research Fund (Project No, E03020130036), Algeria.
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