European Journal of Chemistry 2017, 8(2), 105-108 | doi: https://doi.org/10.5155/eurjchem.8.2.105-108.1541 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives


Mohammed El-Fal (1) , Karima Sayah (2) , Ilias Marmouzi (3) , My El Abbes Faouzi (4) , M'hammed Ansar (5) , Jamal Taoufik (6) , El Mokhtar Essassi (7) , Youssef Ramli (8,*)

(1) Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(2) Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(3) Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(4) Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(5) Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(6) Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(7) Laboratory of Organic Heterocyclic Chemistry URAC 21, Faculty of Sciences, Mohammed V University, 10170, Rabat, Morocco
(8) Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
(*) Corresponding Author

Received: 31 Dec 2016 | Revised: 20 Jan 2017 | Accepted: 11 Feb 2017 | Published: 30 Jun 2017 | Issue Date: June 2017

Abstract


A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and α-glucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for α-amylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for α-glucosidase.


Announcements


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and May 31, 2023 (Voucher code: SPONSOR2023).

Editor-in-Chief
European Journal of Chemistry

Keywords


α-Amylase; IC50 values; α-Glucosidase; Inhibitory activity; 1,3-Dipolarcyclo addition; Pyrazolo[3,4-d]pyrimidine

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.8.2.105-108.1541

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1489 times | icon graph PDF Article downloaded 535 times

Funding information


Pharmaceutical Laboratories SOTHEMA, Morocco

Citations

/


[1]. Younes Zaoui, Youssef Ramli, Sang Loon Tan, Edward R.T. Tiekink, Laila Chemlal, Joel T. Mague, Jamal Taoufik, M. E. Abbes Faouzi, M'Hammed Ansar
Synthesis, structural characterisation and theoretical studies of a novel pyridazine derivative: Investigations of anti-inflammatory activity and inhibition of α-glucosidase
Journal of Molecular Structure  1234, 130177, 2021
DOI: 10.1016/j.molstruc.2021.130177
/

[2]. Mohammed Hussen Bule , Roghaieh Esfandyari, Tadesse Bekele Tafesse, Mohsen Amini, Mohammad Ali Faramarzi, Mohammad Abdollahi
Synthesis, Molecular Docking and α-Glucosidase Inhibitory Activity Study of 2,4,6-triaryl Pyrimidine Derivatives
Letters in Drug Design & Discovery  17(10), 1216, 2020
DOI: 10.2174/1570180817666200103130536
/

References


[1]. IDF Diabetes Atlas. Brussels, Belgium: International Diabetes Federation, 7th ed. 2015, http://www.diabetesatlas.org

[2]. Rossi, E. J.; Sim, L.; Kuntz, D. A.; Hahn, D.; Johnston, B. D.; Ghavami, A.; Rose, D. R. Fed. Eur. Biochem. Soc. J. 2006, 273, 2673-2683.

[3]. Matthews, D. R.; Hosker, J. P.; Rudenski, A. S.; Naylor, B. A.; Treacher, D. F.; Turner, R. C. Diabetologia. 1985, 28, 412-419.
https://doi.org/10.1007/BF00280883

[4]. Kawahito, S.; Kitahata, H.; Oshita, S. World J. Gastroentero. 2009, 15, 4137-4142.
https://doi.org/10.3748/wjg.15.4137

[5]. Saltos, M. B. V.; Puente, B. F. N.; Faraone, I.; Milella, L.; De Tommasi, N.; Braca, A. Phytochem. Lett. 2015, 14, 45-50.
https://doi.org/10.1016/j.phytol.2015.08.018

[6]. Kim, J. S.; Kwon, C. S.; Son, K. H. Biosci. Biotech. Bioch. 2000, 64, 2458-2461.
https://doi.org/10.1271/bbb.64.2458

[7]. Kwon, Y. I.; Apostolidis, E.; Shetty, K. J. Food Biochem. 2007, 31, 370-385.
https://doi.org/10.1111/j.1745-4514.2007.00120.x

[8]. Hano, C.; Renouard, S.; Molinie, R. Bioorg. Med. Chem. Lett. 2013, 23, 3007-3012.
https://doi.org/10.1016/j.bmcl.2013.03.029

[9]. Ramadhan, R.; Phuwapraisirisan, P. Bioorg. Med. Chem. Lett. 2015, 25, 2529-2533.
https://doi.org/10.1016/j.bmcl.2015.08.069

[10]. Mahmoud, H. I.; El-Rab, S. M. G. B, Khalil, A. F.; Ismael, S. M. Eur. J. Chem. 2014, 5, 65‐72.
https://doi.org/10.5155/eurjchem.5.1.65-72.903

[11]. Taher, M. A. H.; Dawood, D. H.; Sanad, M. I.; Hassan, R. A. Eur. J. Chem. 2016, 7, 397‐404.
https://doi.org/10.5155/eurjchem.7.4.397-404.1478

[12]. McInnes, G. T.; Lawson, D. H.; Jick, H. Ann. Rheum. Dis. 1981, 40, 245-249.
https://doi.org/10.1136/ard.40.3.245

[13]. Gruchalla, R. S.; J. Allergy Clin. Immunol. 2003, 111, 548-559.
https://doi.org/10.1067/mai.2003.93

[14]. Zimmerman, H. J.; Maddrey, W. C. Hepatology 1995, 22, 767-773.
https://doi.org/10.1002/hep.1840220312

[15]. Horsmans, Y. Gastroenterol Clin. Biol. 1993, 17, 25-30.
https://doi.org/10.1097/00004836-199307000-00008

[16]. El Fal, M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2014, 70, o1005-o1006.
https://doi.org/10.1107/S160053681401825X

[17]. El Fal, M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2014, 70, o1038-o1038.
https://doi.org/10.1107/S1600536814018042

[18]. El Fal, M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2013, 69, o1650-o1650.
https://doi.org/10.1107/S160053681302789X

[19]. El Fal, M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2015, 71, o95-o96.
https://doi.org/10.1107/S2052520615000864

[20]. Alsubari, A.; Ramli, Y.; Essassi, E. M.; Zouihri, H. Acta Cryst. E 2011, 67, o1926-o1926.
https://doi.org/10.1107/S1600536811025025

[21]. El Fal, M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2015, 71, o769-o770.

[22]. El Fal M.; Ramli, Y.; Essassi, E. M.; Saadi, M.; El Ammari, L. Acta Cryst. E 2014, 70, o1281-o1281.
https://doi.org/10.1107/S1600536814025239

[23]. El Fal, M.; Ramli, Y.; Zerzouf, A.; Talbaoui, A.; Bakri, Y.; Essassi, E. M. J. Chem. 2015, Article ID 982404, http://dx.doi.org/10.1155/2015/982404
https://doi.org/10.1155/2015/982404

[24]. Sayah, K.; Marmouzi, I.; NaceiriMrabti, H.; Cherrah, Y.; Faouzi, M. E. A. Biomed. Res. Int. 2017, 7, ID 2789482, http://dx.doi.org/10.1155/2017/2789482
https://doi.org/10.1155/2017/2789482

[25]. Bhandari, M. R.; Jong-Anurakkun, N.; Hong, G.; Kawabata, J. Food Chem. 2008, 106, 247-252.
https://doi.org/10.1016/j.foodchem.2007.05.077

[26]. Hollander, P. Drugs 1992, 44, 47-79.
https://doi.org/10.2165/00003495-199200443-00007

[27]. Toeller, M. Eur. J. Clin. Invest. 1994, 24, 31-35.
https://doi.org/10.1111/j.1365-2362.1994.tb02253.x


How to cite


El-Fal, M.; Sayah, K.; Marmouzi, I.; Faouzi, M.; Ansar, M.; Taoufik, J.; Essassi, E.; Ramli, Y. Eur. J. Chem. 2017, 8(2), 105-108. doi:10.5155/eurjchem.8.2.105-108.1541
El-Fal, M.; Sayah, K.; Marmouzi, I.; Faouzi, M.; Ansar, M.; Taoufik, J.; Essassi, E.; Ramli, Y. Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives. Eur. J. Chem. 2017, 8(2), 105-108. doi:10.5155/eurjchem.8.2.105-108.1541
El-Fal, M., Sayah, K., Marmouzi, I., Faouzi, M., Ansar, M., Taoufik, J., Essassi, E., & Ramli, Y. (2017). Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives. European Journal of Chemistry, 8(2), 105-108. doi:10.5155/eurjchem.8.2.105-108.1541
El-Fal, Mohammed, Karima Sayah, Ilias Marmouzi, My El Abbes Faouzi, M'hammed Ansar, Jamal Taoufik, El Mokhtar Essassi, & Youssef Ramli. "Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives." European Journal of Chemistry [Online], 8.2 (2017): 105-108. Web. 29 May. 2023
El-Fal, Mohammed, Sayah, Karima, Marmouzi, Ilias, Faouzi, My, Ansar, M'hammed, Taoufik, Jamal, Essassi, El Mokhtar, AND Ramli, Youssef. "Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.8.2.105-108.1541


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2017, 8(2), 105-108 | doi: https://doi.org/10.5155/eurjchem.8.2.105-108.1541 | Get rights and content

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c)




© Copyright 2010 - 2023 • Atlanta Publishing House LLC • All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.