European Journal of Chemistry

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

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Published: Jun 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.2.105-108.1541
Keywords:
α-Amylase, IC50 values, α-Glucosidase, Inhibitory activity, 1, 3-Dipolarcyclo addition, Pyrazolo[3, 4-d]pyrimidine
Section
Research Article
Issue
Vol. 8 No. 2 (2017): June 2017
Dates
Received 2016-12-31
Accepted 2017-02-11
Published 2017-06-30


Main Article Content

Mohammed El-Fal
Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
Karima Sayah
Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
Ilias Marmouzi
Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
My El Abbes Faouzi
Laboratories of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
M'hammed Ansar
Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
Jamal Taoufik
Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco
El Mokhtar Essassi
Laboratory of Organic Heterocyclic Chemistry URAC 21, Faculty of Sciences, Mohammed V University, 10170, Rabat, Morocco
Youssef Ramli
Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10170, Rabat, Morocco

Abstract

A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and α-glucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for α-amylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for α-glucosidase.


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El-Fal, M.; Sayah, K.; Marmouzi, I.; Faouzi, M. E. A.; Ansar, M.; Taoufik, J.; Essassi, E. M.; Ramli, Y. Synthesis, and Evaluation of α-Amylase and α-Glucosidase Inhibitory Potential of New pyrazolo[3,4-d]pyrimidine Derivatives. Eur. J. Chem. 2017, 8, 105-108.

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