European Journal of Chemistry

Synthesis, and evaluation of α-amylase and α-glucosidase inhibitory potential of new pyrazolo[3,4-d]pyrimidine derivatives

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Mohammed El-Fal
Karima Sayah
Ilias Marmouzi
My El Abbes Faouzi
M'hammed Ansar
Jamal Taoufik
El Mokhtar Essassi
Youssef Ramli


A series of new pyrazolo[3,4-d]pyrimidine compounds were synthesized in excellent yields via sulfuration and 1,3-dipolar cycloaddition and confirmed by MS, FT-IR and NMR techniques. All the prepared compounds were screened in vitro for their α-amylase and α-glucosidase inhibitory activities. Preliminary results indicated that some target compounds exhibited promising α-amylase and α-glucosidase inhibitory activity potency. Among the tested products, the cycloadduct f was found most active inhibitor (IC50 = 134.30 μM) for α-amylase, and the sulphur product b is the most active inhibitor (IC50 = 16.37 μM) for α-glucosidase.

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El-Fal, M.; Sayah, K.; Marmouzi, I.; Faouzi, M. E. A.; Ansar, M.; Taoufik, J.; Essassi, E. M.; Ramli, Y. Synthesis, and Evaluation of α-Amylase and α-Glucosidase Inhibitory Potential of New pyrazolo[3,4-d]pyrimidine Derivatives. Eur. J. Chem. 2017, 8, 105-108.

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Pharmaceutical Laboratories SOTHEMA, Morocco
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