

New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method
Hossameldin Ali Aziz (1)





(1) Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
(2) Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
(3) Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
(4) Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
(5) Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
(*) Corresponding Author
Received: 26 Jan 2017 | Revised: 12 Mar 2017 | Accepted: 13 Mar 2017 | Published: 30 Jun 2017 | Issue Date: June 2017
Abstract
Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroaniline diazonium salt accelerated the coupling process and shortened the overall assessment time. The improved detection limits and enhanced sensitivity would pave the way for the future application of this method in nitrite determination in biological or non-biological systems.
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European Journal of Chemistry
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DOI: 10.5155/eurjchem.8.2.119-124.1549
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Faculty of Pharmaceutical Sciences, The University of British Columbia, Canada
Citations
[1]. Hend A. A. Ezelarab, Samar H. Abbas, Mohammed A. S. Abourehab, Mohamed Badr, Sanya Sureram, Poonpilas Hongmanee, Prasat Kittakoop, Gamal El-Din A. Abuo-Rahma, Heba A. Hassan
Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity
Medicinal Chemistry Research 30(12), 2168, 2021
DOI: 10.1007/s00044-021-02798-3

[2]. Hossameldin A. Aziz, Gamal A. I. Moustafa, Samar H. Abbas, Glenn Hauk, Vagolu Siva Krishna, Dharmarajan Sriram, James M. Berger, Gamal El-Din A. Abuo-Rahma
New fluoroquinolones/nitric oxide donor hybrids: design, synthesis and antitubercular activity
Medicinal Chemistry Research 28(8), 1272, 2019
DOI: 10.1007/s00044-019-02372-y

[3]. Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Sandra Mădălina Constantin, Florentina Geanina Lupașcu, Alin Viorel Focșa, Lenuţa Profire
Design, Synthesis, In Silico and In Vitro Studies for New Nitric Oxide-Releasing Indomethacin Derivatives with 1,3,4-Oxadiazole-2-thiol Scaffold
International Journal of Molecular Sciences 22(13), 7079, 2021
DOI: 10.3390/ijms22137079

[4]. Alexandru Sava, Frederic Buron, Sylvain Routier, Alina Panainte, Nela Bibire, Lenuţa Profire
New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies
Biomedicine & Pharmacotherapy 139, 111678, 2021
DOI: 10.1016/j.biopha.2021.111678

[5]. Hossameldin A. Aziz, Gamal A. I. Moustafa, Gamal El‐Din A. Abuo‐Rahma, Safwat M. Rabea, Glenn Hauk, Vagolu S. Krishna, Dharmarajan Sriram, James M. Berger, Samar H. Abbas
Synthesis and antimicrobial evaluation of new nitric oxide‐donating fluoroquinolone/oxime hybrids
Archiv der Pharmazie 354(1), 2000180, 2021
DOI: 10.1002/ardp.202000180

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DOI Link: https://doi.org/10.5155/eurjchem.8.2.119-124.1549

















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