European Journal of Chemistry

New norfloxacin/nitric oxide donor hybrids: Synthesis and nitric oxide release measurement using a modified Griess colorimetric method

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Published: Jun 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.2.119-124.1549
Keywords:
Nitrite, Norfloxacin, Diazotization, 4-Nitroaniline, Nitric oxide donors, Griess colorimetric assay
Section
Research Article
Issue
Vol. 8 No. 2 (2017): June 2017
Dates
Received 2017-01-26
Accepted 2017-03-13
Published 2017-06-30


Main Article Content

Hossameldin Ali Aziz
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Gamal Abdeltawab Idris Moustafa
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Samar Hafez Abbas
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Sayed Mohamed Derayea
Department of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt
Gamal El-Din Ali Ahmed Abuo-Rahma
Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt

Abstract

Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroaniline diazonium salt accelerated the coupling process and shortened the overall assessment time. The improved detection limits and enhanced sensitivity would pave the way for the future application of this method in nitrite determination in biological or non-biological systems.


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Aziz, H. A.; Moustafa, G. A. I.; Abbas, S. H.; Derayea, S. M.; Abuo-Rahma, G. E.-D. A. A. New Norfloxacin Nitric Oxide Donor Hybrids: Synthesis and Nitric Oxide Release Measurement Using a Modified Griess Colorimetric Method. Eur. J. Chem. 2017, 8, 119-124.

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Faculty of Pharmaceutical Sciences, The University of British Columbia, Canada
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