European Journal of Chemistry 2017, 8(2), 183-187 | doi: | Get rights and content

Issue cover


Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity

Ramiz Hoti (1) , Naser Troni (2,*) , Hamit Ismaili (3) , Gjyle Mulliqi-Osmani (4) , Veprim Thaçi (5)

(1) Department of Chemistry, University of Prishtina, Prishtina, 10000, Kosovo
(2) Department of Chemistry, University of Prishtina, Prishtina, 10000, Kosovo
(3) Department of Chemistry, University of Prishtina, Prishtina, 10000, Kosovo
(4) Institute of Public Health of Kosovo, Prishtina, 10000, Kosovo
(5) Department of Chemistry, University of Prishtina, Prishtina, 10000, Kosovo
(*) Corresponding Author

Received: 13 Mar 2017 | Revised: 18 May 2017 | Accepted: 29 Apr 2017 | Published: 30 Jun 2017 | Issue Date: June 2017


A series of new azetidin-2-ones, on the basis of 3-nitrobenzopyran-2-one were synthesized by cyclo-condensation of various Schiff bases of coumarin with acetyl chloride. 4-(2-Amino-ethylamino)-3-nitro-chromen-2-one (3) is synthesized by condensation of 4-chloro-3-nitrobenzopyran-2-one (2) and ethane-1,2-diamine. The catalytic condensation of compound 3 with benzaldehyde, salicylaldehyde or 3-nitrobenzaldehyde yielded corresponding 4-[4-(benzylidene-amino)-phenylamino]-3-nitrobenzopyran-2-ones, 4a-c. The cyclization reac-tion of compounds 4a-c with acetyl chloride yielded corresponding substituted azetidin-2-ones, 5a-c. The structures of the obtained compounds were established by FT-IR and NMR spectrometric data and their elemental analysis. Prepared compounds 4a-c and 5a-c were screened for their antibacterial activity against S. aureus, E. coli and Klebsiella by disc diffusion method. Compounds 4a-c exhibited moderate antibacterial activity, whereas compounds 5a-c displayed significant activity against these microorganisms. The impact of substitutions in antimicrobial activity was also explored.


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).

European Journal of Chemistry


Coumarin; Schiff bases; Azetidin-2-one; Benzopyran-2-one; Antibacterial activity; Catalytic condensation

Full Text:

PDF    Open Access

DOI: 10.5155/eurjchem.8.2.183-187.1565

Links for Article

| | | | | | |

| | | | | | |

| | | |

Related Articles

Article Metrics

icon graph This Abstract was viewed 1288 times | icon graph PDF Article downloaded 579 times

Funding information

Division of Organic Chemistry and Biochemistry Institute “Rudjer Boskovic”, Zagreb, Croatia


[1]. Christos, A.; Kontogiorgis, D.; Hadjipavlou-Litina, J. Bioorg. Med. Chem. Lett. 2004, 14(3), 611-614.

[2]. Stockley, I. Br. Med. J. (Clin. Res. Ed). 1982, 285(6350), 1278-1278.

[3]. Mohamed, H. M.; Abd El-Wahab, A. H. F.; Ahmed, K. A.; El-Agrody, A. M.; Bedair, A. H.; Eid, F. A.; Khafagy, M. M. Molecules 2012, 17, 971-988.

[4]. De Souza, S. M.; Delle Monache, F.; Smania, A. Jr. Z. Naturforsch. C 2005, 60(9-10), 693-700.

[5]. Rajasekaran, S.; Rao, G. K.; Pai, S.; Rajan, A. Inter. J. Chem. Tech. Res. 2011, 3(2), 555-559.

[6]. Montagner, C.; De Souza, S. M.; Groposoa, C.; Delle Monache, F.; Smania, E. F.; Smania, A. Jr. Z. Naturforsch. C 2008, 63(1-2), 21-28.

[7]. Pingaew, R.; Saekee, A.; Mandi, P.; Nantasenamat, C.; Prachayasittikul, S.; Ruchirawat, S.; Prachayasittikul, V. Eur. J. Med. Chem. 2014, 6(85), 65-76.

[8]. Bubols, G. B.; Vianna, D. R.; Medina-Remon, A.; von Poser, G.; Lamuela-Raventos, R. M.; Eifler-Lima, V. L.; Garcia, S. C. Mini Rev. Med. Chem. 2013, 13(3), 318-334.

[9]. Rodriguez, S. V.; Guinez, R. F.; Matos, M. J.; Santana, L.; Uriarte, E.; Lapier, M.; Maya, J. D.; Azar, C. O. Med. Chem. Commun. 2013, 4, 993-1000.

[10]. Keri, R. S.; Sasidhar, B. S.; Nagaraja, B. M.; Santos, M. A. Eur. J. Med. Chem. 2015, 100, 257-269.

[11]. Kamelia, M.; Amin, D. E.; Abdel, R.; Yasmin, A. Bioorg. Med. Chem. 2008, 16(10), 5377-5388.

[12]. Naveed, M.; Mohammad, S.; Haroon, K.; Achyut, A.; Khalid, M. K. J. Chem. 2013, Article ID 326263, 6 pages.

[13]. Ghate, M.; Kusanur, R. A.; Kulkarni, M. V. Eur. J. Med. Chem. 2005, 40(9), 882-887.

[14]. Kostova, I. Curr. HIV. Res. 2006, 4(3), 347-363.

[15]. Atmaca, M.; Bilgin, H. M.; Obay, B. D.; Diken, H.; Kelle, M.; Kale, E. J. Physiol. Biochem. 2011, 67(4), 569-576.

[16]. Kuppers, J.; Schulz-Fincke, A. C.; Palus, J.; Giurg, M.; Skarżewski, J.; Gütschow, M. Pharmaceuticals 2016, 9(3), 43, 1-11.

[17]. Rajasekaran, A.; Periasamy, M.; Venkatesan, S. J. Develop. Bio. Tiss. Eng. 2010, 2(1), 5-6.

[18]. Desai, S. R.; Laddi, U. V.; Bennur, R. S; Bennur, S. C. Indian J. Pharm. Sci. 2011, 73(4), 478-482.

[19]. Gupta, A.; Halve, A. K. Open Chem. J. 2015, 2, 1-6.

[20]. Gilani, S. J.; Alam, O.; Khan, S. A.; Siddiqui, N.; Kumar, H. Der Pharm. Lett. 2009, 1(2), 1-8.

[21]. Rao, A.; Carbone, A.; Chimirri, A.; De Clercq, E.; Monforte, A. M.; Monforte, P.; Pannecouque, C.; Zappala, M. Farmaco 2002, 57(9), 747-751.

[22]. Hoti, R.; Nura-Lama, A.; Mulliqi-Osmani, Gj.; Troni, N.; Gashi, F.; Ismaili, H.; Thaçi, V. Orbital: The Elect. J. Chem. 2014, 6(3), 184-190.

[23]. Hoti, R.; Kalaj, V.; Vehapi, I.; Ismaili, H.; Thaçi, V.; Bicaj, M. The FASEB J. Exp. Bio. 2010, lb487, Anaheim Ca. Apr. 2010,

[24]. Bauer, A. W. Am. J. Clin. Pathol. 1966, 44, 493-496.

How to cite

Hoti, R.; Troni, N.; Ismaili, H.; Mulliqi-Osmani, G.; Thaçi, V. Eur. J. Chem. 2017, 8(2), 183-187. doi:10.5155/eurjchem.8.2.183-187.1565
Hoti, R.; Troni, N.; Ismaili, H.; Mulliqi-Osmani, G.; Thaçi, V. Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity. Eur. J. Chem. 2017, 8(2), 183-187. doi:10.5155/eurjchem.8.2.183-187.1565
Hoti, R., Troni, N., Ismaili, H., Mulliqi-Osmani, G., & Thaçi, V. (2017). Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity. European Journal of Chemistry, 8(2), 183-187. doi:10.5155/eurjchem.8.2.183-187.1565
Hoti, Ramiz, Naser Troni, Hamit Ismaili, Gjyle Mulliqi-Osmani, & Veprim Thaçi. "Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity." European Journal of Chemistry [Online], 8.2 (2017): 183-187. Web. 3 Jun. 2023
Hoti, Ramiz, Troni, Naser, Ismaili, Hamit, Mulliqi-Osmani, Gjyle, AND Thaçi, Veprim. "Some new [(chromen-4-ylamino)-ethyl]-azetidin-2-ones and their antibacterial activity" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item

DOI Link:

CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley

European Journal of Chemistry 2017, 8(2), 183-187 | doi: | Get rights and content


  • There are currently no refbacks.

Copyright (c)

© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.