European Journal of Chemistry

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine

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Maria Aqeel Khan
Farhana Batool
Asma Khatoon
Rabia Sadiq
Sher Rahman
Fatima Zehra Basha


Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).

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How to Cite
Khan, M. A.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Z. Solvent-Free Protocol for the Green Synthesis of Benzamide Analogs of Dibenzoazepine. Eur. J. Chem. 2017, 8, 179-182.

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Supporting Agencies

Higher Education Commission (HEC), Pakistan and H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

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