European Journal of Chemistry

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine

Article Sidebar

PDF
Published: Jun 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.2.179-182.1567
Keywords:
Amidation, Benzamides, Solvent-free, Dibenzoazepine, Benzoyl chlorides, Green methodology
Section
Research Article
Issue
Vol. 8 No. 2 (2017): June 2017
Dates
Received 2017-03-16
Accepted 2017-04-19
Published 2017-06-30


Main Article Content

Maria Aqeel Khan
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Farhana Batool
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Asma Khatoon
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Rabia Sadiq
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Sher Rahman
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Fatima Zehra Basha
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract

Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).


icon graph This Abstract was viewed 1841 times | icon graph Article PDF downloaded 830 times

How to Cite
(1)
Khan, M. A.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Z. Solvent-Free Protocol for the Green Synthesis of Benzamide Analogs of Dibenzoazepine. Eur. J. Chem. 2017, 8, 179-182.

Article Details

Share
Links for Article


Crossref - Scopus - Google - European PMC
Crossref
Scopus
Google Scholar
Europe PMC
References

[1]. Kumar, H. V.; Kumar, P.; Rangaswamy, J.; Sindhu, K. U.; Naik, N. Eur. J. Chem. 2015, 6, 394-403.
https://doi.org/10.5155/eurjchem.6.4.394-403.1297

[2]. Manjunath, B. C.; Kumar, K. S. V.; Kumar, S. M.; Sadashiva M. P.; Lokanath, N. K. Acta Cryst. E 2013, 69, o1763-o1763.
https://doi.org/10.1107/S1600536813030547

[3]. Yousuf, S.; Khan, M.; Fazal, S.; Butt, M.; Basha, F. Z. Acta Cryst. E 2012, 68, o1101-o1101.
https://doi.org/10.1107/S1600536812007866

[4]. Patton, J. R.; Dudley, K. H. J. Heterocyclic Chem. 1979, 16, 257-262.
https://doi.org/10.1002/jhet.5570160213

[5]. Chang, V. H. T. J. Heterocyclic Chem. 1983, 20, 237-238.
https://doi.org/10.1002/jhet.5570200149

[6]. Kovacs, N.; Nagy, F.; Balas, I.; Komoly, S.; Janszky, J. Epilepsy Behav. 2008, 12, 492-493.
https://doi.org/10.1016/j.yebeh.2007.12.010

[7]. Khan, M. A.; Saleem, A.; Ghouri, N.; Hameed, A.; Choudhary, M. I.; Basha, F. Z. Lett. Drug. Des. Discov. 2015, 12, 597-606.
https://doi.org/10.2174/1570180812999150225111959

[8]. Kumar, H. V.; Naik, N. Eur. J. Med. Chem. 2010, 45, 2-10.
https://doi.org/10.1016/j.ejmech.2009.09.016

[9]. Takayama, H.; Yaegashi, Y.; Kitajima, M.; Han, X.; Nishimura, K.; Okuyama, S.; Igarashi, K. Bioorg. Med. Chem. Lett. 2007, 17, 4729-4732.
https://doi.org/10.1016/j.bmcl.2007.06.069

[10]. Bag, S.; Tawari, N. R.; Degani, M. S.; Queener, S. F. Bioorg. Med. Chem. 2010, 18, 3187-3197.
https://doi.org/10.1016/j.bmc.2010.03.031

[11]. Confalone, P. N.; Huie, E. M. J. Org. Chem. 1984, 48, 2994-2997.
https://doi.org/10.1021/jo00166a011

[12]. David-Cordonnier, M. H.; Hildebrand, M. P.; Baldeyrou, B.; Lansiaux, A.; Keuser, C.; Benzschawel, K.; Lemster, T.; Pindur, U. Eur. J. Med. Chem. 2007, 42, 752-771.
https://doi.org/10.1016/j.ejmech.2006.12.039

[13]. Burstein, E. S. US patent 20060252744 A1 (2006).

[14]. Balaure, P. C.; Costea, I.; Florin, I.; Draghici, C.; Enache, C. Rev. Roum. Chim. 2009, 54, 935-942.

[15]. Martinez, R.; Ruben, C.; Espinosa, R. C.; Toscano, R. A.; Cogordan, J. A.; Arellano, M. D. R.; Angeles, E.; Posada, M. D. R.; Maya, B.; Martine, L. J. Heterocyclic Chem. 1996, 33, 715-718.
https://doi.org/10.1002/jhet.5570330332

Supporting Agencies

Higher Education Commission (HEC), Pakistan and H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Most read articles by the same author(s)
TrendMD

Dimensions - Altmetric - scite_ - PlumX

Downloads and views

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...
License Terms

License Terms

by-nc

Copyright © 2025 by Authors. This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at https://www.eurjchem.com/index.php/eurjchem/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution, or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (https://www.eurjchem.com/index.php/eurjchem/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).