European Journal of Chemistry

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine

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Published: Jun 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.2.179-182.1567
Keywords:
Amidation, Benzamides, Solvent-free, Dibenzoazepine, Benzoyl chlorides, Green methodology
Section
Research Article
Issue
Vol. 8 No. 2 (2017): June 2017
Dates
Received 2017-03-16
Accepted 2017-04-19
Published 2017-06-30


Main Article Content

Maria Aqeel Khan
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Farhana Batool
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Asma Khatoon
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Rabia Sadiq
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Sher Rahman
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Fatima Zehra Basha
Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Abstract

Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).


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How to Cite
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Khan, M. A.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Z. Solvent-Free Protocol for the Green Synthesis of Benzamide Analogs of Dibenzoazepine. Eur. J. Chem. 2017, 8, 179-182.

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Supporting Agencies

Higher Education Commission (HEC), Pakistan and H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
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