European Journal of Chemistry 2017, 8(2), 179-182 | doi: https://doi.org/10.5155/eurjchem.8.2.179-182.1567 | Get rights and content

Issue cover





  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine


Maria Aqeel Khan (1) , Farhana Batool (2,*) , Asma Khatoon (3) , Rabia Sadiq (4) , Sher Rahman (5) , Fatima Zehra Basha (6)

(1) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(2) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(3) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(4) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(5) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(6) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(*) Corresponding Author

Received: 16 Mar 2017 | Revised: 14 Apr 2017 | Accepted: 19 Apr 2017 | Published: 30 Jun 2017 | Issue Date: June 2017

Abstract


Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).


Announcements


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and June 16, 2023 (Voucher code: SPONSOR2023).

Editor-in-Chief
European Journal of Chemistry

Keywords


Amidation; Benzamides; Solvent-free; Dibenzoazepine; Benzoyl chlorides; Green methodology

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.8.2.179-182.1567

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 1192 times | icon graph PDF Article downloaded 472 times

Funding information


Higher Education Commission (HEC), Pakistan and H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Citations

/


[1]. Sheeba Wajid, Asma Khatoon, Maria Aqeel Khan, Humaira Zafar, Shama Kanwal, Atta-ur-Rahman, M. Iqbal Choudhary, Fatima Z. Basha
Microwave-Assisted Organic Synthesis, structure–activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry  27(18), 4030, 2019
DOI: 10.1016/j.bmc.2019.07.015
/


References


[1]. Kumar, H. V.; Kumar, P.; Rangaswamy, J.; Sindhu, K. U.; Naik, N. Eur. J. Chem. 2015, 6, 394-403.
https://doi.org/10.5155/eurjchem.6.4.394-403.1297

[2]. Manjunath, B. C.; Kumar, K. S. V.; Kumar, S. M.; Sadashiva M. P.; Lokanath, N. K. Acta Cryst. E 2013, 69, o1763-o1763.
https://doi.org/10.1107/S1600536813030547

[3]. Yousuf, S.; Khan, M.; Fazal, S.; Butt, M.; Basha, F. Z. Acta Cryst. E 2012, 68, o1101-o1101.
https://doi.org/10.1107/S1600536812007866

[4]. Patton, J. R.; Dudley, K. H. J. Heterocyclic Chem. 1979, 16, 257-262.
https://doi.org/10.1002/jhet.5570160213

[5]. Chang, V. H. T. J. Heterocyclic Chem. 1983, 20, 237-238.
https://doi.org/10.1002/jhet.5570200149

[6]. Kovacs, N.; Nagy, F.; Balas, I.; Komoly, S.; Janszky, J. Epilepsy Behav. 2008, 12, 492-493.
https://doi.org/10.1016/j.yebeh.2007.12.010

[7]. Khan, M. A.; Saleem, A.; Ghouri, N.; Hameed, A.; Choudhary, M. I.; Basha, F. Z. Lett. Drug. Des. Discov. 2015, 12, 597-606.
https://doi.org/10.2174/1570180812999150225111959

[8]. Kumar, H. V.; Naik, N. Eur. J. Med. Chem. 2010, 45, 2-10.
https://doi.org/10.1016/j.ejmech.2009.09.016

[9]. Takayama, H.; Yaegashi, Y.; Kitajima, M.; Han, X.; Nishimura, K.; Okuyama, S.; Igarashi, K. Bioorg. Med. Chem. Lett. 2007, 17, 4729-4732.
https://doi.org/10.1016/j.bmcl.2007.06.069

[10]. Bag, S.; Tawari, N. R.; Degani, M. S.; Queener, S. F. Bioorg. Med. Chem. 2010, 18, 3187-3197.
https://doi.org/10.1016/j.bmc.2010.03.031

[11]. Confalone, P. N.; Huie, E. M. J. Org. Chem. 1984, 48, 2994-2997.
https://doi.org/10.1021/jo00166a011

[12]. David-Cordonnier, M. H.; Hildebrand, M. P.; Baldeyrou, B.; Lansiaux, A.; Keuser, C.; Benzschawel, K.; Lemster, T.; Pindur, U. Eur. J. Med. Chem. 2007, 42, 752-771.
https://doi.org/10.1016/j.ejmech.2006.12.039

[13]. Burstein, E. S. US patent 20060252744 A1 (2006).

[14]. Balaure, P. C.; Costea, I.; Florin, I.; Draghici, C.; Enache, C. Rev. Roum. Chim. 2009, 54, 935-942.

[15]. Martinez, R.; Ruben, C.; Espinosa, R. C.; Toscano, R. A.; Cogordan, J. A.; Arellano, M. D. R.; Angeles, E.; Posada, M. D. R.; Maya, B.; Martine, L. J. Heterocyclic Chem. 1996, 33, 715-718.
https://doi.org/10.1002/jhet.5570330332


How to cite


Khan, M.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Eur. J. Chem. 2017, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, M.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine. Eur. J. Chem. 2017, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, M., Batool, F., Khatoon, A., Sadiq, R., Rahman, S., & Basha, F. (2017). Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine. European Journal of Chemistry, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, Maria, Farhana Batool, Asma Khatoon, Rabia Sadiq, Sher Rahman, & Fatima Zehra Basha. "Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine." European Journal of Chemistry [Online], 8.2 (2017): 179-182. Web. 4 Jun. 2023
Khan, Maria, Batool, Farhana, Khatoon, Asma, Sadiq, Rabia, Rahman, Sher, AND Basha, Fatima. "Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.8.2.179-182.1567


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2017, 8(2), 179-182 | doi: https://doi.org/10.5155/eurjchem.8.2.179-182.1567 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c)





© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.