European Journal of Chemistry 2017, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine


Maria Aqeel Khan (1) , Farhana Batool (2,*) , Asma Khatoon (3) , Rabia Sadiq (4) , Sher Rahman (5) , Fatima Zehra Basha (6)

(1) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(2) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(3) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(4) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(5) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(6) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(*) Corresponding Author

Received: 16 Mar 2017, Accepted: 19 Apr 2017, Published: 30 Jun 2017

Abstract


Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).


Keywords


Amidation; Benzamides; Solvent-free; Dibenzoazepine; Benzoyl chlorides; Green methodology

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DOI: 10.5155/eurjchem.8.2.179-182.1567

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Citations

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[1]. Sheeba Wajid, Asma Khatoon, Maria Aqeel Khan, Humaira Zafar, Shama Kanwal, Atta-ur-Rahman, M. Iqbal Choudhary, Fatima Z. Basha
Microwave-Assisted Organic Synthesis, structure–activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry  27(18), 4030, 2019
DOI: 10.1016/j.bmc.2019.07.015
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How to cite


Khan, M.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Eur. J. Chem. 2017, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, M.; Batool, F.; Khatoon, A.; Sadiq, R.; Rahman, S.; Basha, F. Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine. Eur. J. Chem. 2017, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, M., Batool, F., Khatoon, A., Sadiq, R., Rahman, S., & Basha, F. (2017). Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine. European Journal of Chemistry, 8(2), 179-182. doi:10.5155/eurjchem.8.2.179-182.1567
Khan, Maria, Farhana Batool, Asma Khatoon, Rabia Sadiq, Sher Rahman, & Fatima Zehra Basha. "Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine." European Journal of Chemistry [Online], 8.2 (2017): 179-182. Web. 18 Sep. 2019
Khan, Maria, Batool, Farhana, Khatoon, Asma, Sadiq, Rabia, Rahman, Sher, AND Basha, Fatima. "Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine" European Journal of Chemistry [Online], Volume 8 Number 2 (30 June 2017)

DOI Link: https://doi.org/10.5155/eurjchem.8.2.179-182.1567

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