

Solvent-free protocol for the green synthesis of benzamide analogs of dibenzoazepine
Maria Aqeel Khan (1)






(1) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(2) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(3) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(4) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(5) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(6) Hussain Ebrahim Jamal Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
(*) Corresponding Author
Received: 16 Mar 2017 | Revised: 14 Apr 2017 | Accepted: 19 Apr 2017 | Published: 30 Jun 2017 | Issue Date: June 2017
Abstract
Dibenzoazepine represents an important class of heterocycles, exhibiting potent antidepressant and anticonvulsant activities. Beside, various modifications on this nucleus, amide analogs at N-5 position showed potent antidepressant activities. A previously reported method for the synthesis of benzamide analogs of dibenzoazepine use hazardous and toxic solvents. Herein, we report a new, efficient and solvent-free green method for the synthesis of dibenzoazepine benzamides (6-21).
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DOI: 10.5155/eurjchem.8.2.179-182.1567
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Higher Education Commission (HEC), Pakistan and H. E. J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan
Citations
[1]. Sheeba Wajid, Asma Khatoon, Maria Aqeel Khan, Humaira Zafar, Shama Kanwal, Atta-ur-Rahman, M. Iqbal Choudhary, Fatima Z. Basha
Microwave-Assisted Organic Synthesis, structure–activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors
Bioorganic & Medicinal Chemistry 27(18), 4030, 2019
DOI: 10.1016/j.bmc.2019.07.015

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DOI Link: https://doi.org/10.5155/eurjchem.8.2.179-182.1567

















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