European Journal of Chemistry

Structural characterization, biological evaluation and DNA interaction of some potential drugs based on bifunctional aldehyde functionality

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Published: Sep 30, 2017
DOI: https://doi.org/10.5155/eurjchem.8.3.195-202.1576
Keywords:
Hyperchromism, DNA damaging assay, Bifunctional aldehyde, Chemotherapeutic agent, Pharmacological activities, Bifunctional aldehyde-DNA interaction
Section
Research Article
Issue
Vol. 8 No. 3 (2017): September 2017
Dates
Received 2017-04-21
Accepted 2017-06-05
Published 2017-09-30


Main Article Content

Mehwish Naz
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Zareen Akhter
Department of Chemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Ayesha Zaka
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Bushra Mirza
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Vickie McKee
Department of Chemical Sciences, Dublin City University, Glasnevin, Dublin, 9, Ireland
Ehsan Ullah
Department of Biochemistry, Quaid-i-Azam University, Islamabad, 45320, Pakistan
Michael Bolte
Institut für Anorganische Chemie, Johann Wolfgang Goethe-Universität, Frankfurt/Main, D-60438, Germany

Abstract

Recent work aimed at evaluating the possibility of enhancing biological activities by synthetically modifying bifunctional aldehyde structures. In this article, two series of bifunctional aldehydes were synthesized, structurally characterized (M-1A, M-1C and M-2A) using single crystal X-ray diffraction analysis. Several pharmacological properties like cytotoxic, antifungal, antibacterial, antioxidant and antitumor activities were also evaluated. In addition, bifunctional aldehyde-DNA interaction assay was examined by UV-Vis spectroscopy which revealed the DNA damaging behaviour of these aldehydes. The results of UV-Vis spectroscopy were supported by DNA damaging assay. The overall results reveal that bifunctional aldehyde moiety could be used as potential drug candidates.


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Naz, M.; Akhter, Z.; Zaka, A.; Mirza, B.; McKee, V.; Ullah, E.; Bolte, M. Structural Characterization, Biological Evaluation and DNA Interaction of Some Potential Drugs Based on Bifunctional Aldehyde Functionality. Eur. J. Chem. 2017, 8, 195-202.

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