European Journal of Chemistry 2018, 9(1), 22-29 | doi: | Get rights and content

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Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex

Nevin Turan (1,*) orcid , Kenan Buldurun (2) orcid

(1) Department of Chemistry, Faculty of Arts and Sciences, Mus Alparslan University, 49250 Mus, Turkey
(2) Department of Chemistry, Faculty of Arts and Sciences, Mus Alparslan University, 49250 Mus, Turkey
(*) Corresponding Author

Received: 13 Nov 2017 | Revised: 05 Dec 2017 | Accepted: 13 Dec 2017 | Published: 31 Mar 2018 | Issue Date: March 2018


The synthesis, spectral, catalytic and antioxidant properties of ethyl-2-(2-hydroxy-3-methoxybenzylideneamino)-6-methyl-4,5,6-tetrahydrobenzo[b]thiophene-3-carboxylate (L) substituted iron(II), manganese(II), zinc(II), and ruthenium(II)-arene chlorides are described for the first time. The ligand and its metal complexes were characterized by elemental analysis, molar conductance, magnetic susceptibility measurements, and spectral (1H NMR, 13C NMR, FT-IR, UV-Vis and Mass) techniques. The FT-IR spectra showed that the ligand can act as bidentate or tridentate. Magnetic moments and electronic spectral studies revealed an octahedral geometry for all the complexes obtained. The thermal behavior of the complexes showed that the water molecules were separated in the first step followed immediately by decomposition of the anions and ligand molecules in the subsequent steps. Ru(II) complex was used as catalysts for the transfer hydrogenation of ketones. At the same time, the effect of various bases such as NaOH, KOH, KOBut and NaOAc as organic base were investigated in the transfer hydrogenation of ketones by 2-propanol as the hydrogen source. The complexes and ligand were tested in vitro for their antioxidant activity. The experimental results showed that Ru(II) complex had more potent antioxidant activities than Zn(II), Fe(II), Mn(II) complexes and parent ligand.


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European Journal of Chemistry


Metal complexes; Thiophene ligand; Catalytic properties; Structure elucidation; Antioxidant properties; Transfer hydrogenation

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DOI: 10.5155/eurjchem.9.1.22-29.1671

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Mus Alparslan University, 49250 Mus, Turkey.



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[1] Refa, M. S.; El-Sayed, M. Y.; Adam, A. M. J. Mol. Struct. 2013, 1038, 62-72.

[2] Azarkish, M.; Sedaghat, T. Chinese Chem. Lett. 2012, 23, 1063-1066.

[3] Ouyang, X. M.; Fei, B. L.; Okamuro, T. A.; Sun, W. Y.; Tang, W. X.; Ueyama, N. Chem. Lett. 2002, 3, 362-263.

[4] Hanif, M.; Chohan, Z. H. Spectrochim. Acta A 2013, 104, 468-476.

[5] Ahmadi, R. A.; Amani, S. Molecules 2012, 17, 6434-6448.

[6] Ebrahimi, H.; Hadi, J. S.; Al-Ansari, H. S. J. Mol. Struct. 2013, 1039, 37-45.

[7] Prasad, K.; Kumar, L.; Chandan, S.; Vijaya, B.; Revanasiddappa, H. D. An. Univ. Bucure. Chim. 2011, 20, 7-13

[8] Cukurovali, A.; Yilmaz, I.; Ozmen, H.; Ahmedzade, M. Trans. Met. Chem. 2010, 27, 171-176.

[9] Santos, L. H.; Feres, C. A. O.; Melo, F. H.; Coelho, M. M.; Nothenberg, M. S.; Oga, S.; Tagliati, C. A. Braz. J. Med. Biol. Res. 2004, 37, 1205-1213.

[10] Shi, D. H.; Cao, Z. L.; Liu, W. W.; Xu, R. B.; Gao, L. L.; Zhang, Q.; You, Z. Russ. J. Coord. Chem. 2013, 39, 297-300.

[11] Mori, S.; Mochida, T. Organometallics 2013, 32, 780-787.

[12] Nakayama, T.; Yamada, M.; Osawa, T.; Kawakishi, S. Biochem. Pharmacol. 1993, 45, 265-267.

[13] Kanchanadevi, A.; Ramesh, R.; Semeril, D. J. Organomet. Chem. 2016, 808, 68-77.

[14] Singh, K. S.; Devi, P.; Sawant, S. G.; Kaminsky, W. Polyhedron 2015, 100, 321-325.

[15] Pandiarajan, D.; Rengan, R. J. Organomet. Chem. 2013, 723, 26-35.

[16] Calık, H. S.; Ispir, E.; Karabuga, S.; Aslantas, M. J. Organomet. Chem. 2016, 801, 122-129.

[17] Ozcan, E. O.; Mercan, D.; Gurbuz, N.; Cetinkaya, E.; Cetinkaya, B.; Ozdemir, I. Turk. J. Chem. 2011, 35, 699-709.

[18] Del Zotto, A.; Baratta, W.; Ballico, M.; Herdtweck, E.; Rigo, P. Organometallics 2007, 26, 5636-5642.

[19] Zhu, X. H.; Cai, L. H.; Wang, C. X.; Wang, Y. N.; Guo, X. Q.; Hou, X. F. J. Mol. Catal. A: Chem. 2014, 393, 134-141.

[20] Koksal, E.; Bursal, E.; Dikici, E.; Tozoglu, F.; Gulcin, I. J. Med. Plants Res. 2011, 5, 217-222.

[21] Bursal, E.; Gulcin, I. Food Res. Int. 2011, 44, 1482-1489.

[22] Apak, R.; Guclu, K.; Ozyurek, M.; Karademir, S. E. J. Agric. Food Chem. 2004, 52, 7970-7981.

[23] Chandra, S.; Gupta, L. K. Spectrochim. Acta A 2005, 61, 269-275.

[24] Turan, N.; Sekerci, M. Heteroatom. Chem. 2010, 21, 14-23.

[25] Sece, J. M.; Quiros, M.; Garmendia, M. J. G. Polyhedron 2000, 19, 1005-1013.

[26] Turan, N.; Şekerci, M. Spectrosc. Lett. 2009, 42, 258-267.

[27] Turan, N.; Sekerci, M. Synth. React. Inorg. Met.-Org. Chem. 2009, 39, 651-657.

[28] Spinu, C.; Kriza, A.; Spinu, L. Acta Chim. Slov. 2001, 48, 257-264.

[29] Maurya, R. C.; Patel, P. Spectrosc. Lett. 1999, 32, 213-236.

[30] Etaiw, S. H. E.; Abd El-Aziz, D. M.; Abd El-Zaher, E. H.; Ali, E. A. Spectrochim. Acta A 2011, 79, 1331-1337.

[31] Neelakantana, M. A.; Sundarama, M.; Nair, M. S. Spectrochim. Acta A 2011, 79, 1693-1703.

[32] Khalil, S. M. E. J. Coord. Chem. 2003, 56, 1013-1024.

[33] Gichumbi, J. M.; Friedrich, H. B.; Omondi, B. J. Organomet. Chem. 2016, 808, 87-96.

[34] Elsayed, S. A.; Noufal, A. M.; El-Hendawy, A. M. J. Mol. Struct.2017, 1144, 120-128.

[35] Cotton, F. A.; Wilkinson, G.; Murillo, C. A.; Bochmann, M. Advanced Inorganic Chemistry, 6thedition, John Wiley & Sons, 1999.

[36] Sharaby, C. M. Spectrochim. Acta A 2007, 66, 1271-1278.

[37] Mohamed, G. G. Spectrochim. Acta A 2001, 57, 1643-1648.

[38] Mohamed, G. G.; Sharaby, M. C. Spectrochim. Acta A 2007, 66, 949-958.

[39] Refat, M. S. Spectrochim. Acta A 2013, 105, 326-337.

[40] Mahmoud Walaa, H.; Mohamed Gehad, G.; El-Dessouky Maher, M. I. Int. J. Electrochem. Sci. 2014, 9, 1415-1438.

[41] Mohamed Gehad, G.; Zayed, M. A.; Abdallah, S. M. J. Mol. Struct. 2010, 979, 62-71.

[42] Sharaby, C. M. Spectrochim. Acta A 2007, 66, 1271-1278.

[43] Sathyadevi, P.; Krishnamoorthy, P.; Jayanthi, E.; Butorac, R. R.; Cowley, A. H.; Dharmaraj, N. Inorg. Chim. Acta 2012, 384, 83-96.

[44] Mohanraj, M.; Ayyannan, G.; Raja, G.; Jayabalakrishnan, C. J. Photochem. Photobiol. B 2016, 158, 164-173.

[45] Bursal, E. Int. J. Food Prop.2013, 16, 1293-1303.

[46] Turan, N.; Savci, A.; Buldurun, K.; Alan, Y.; Adiguzel, R. Lett Org. Chem. 2016, 13, 343-351.

[47] Isık, M.; Korkmaz, M.; Bursal, E.; Gulcin, I.; Koksal, E.; Tohma, H. Int. J. Pharm. 2015, 11, 366-371.

How to cite

Turan, N.; Buldurun, K. Eur. J. Chem. 2018, 9(1), 22-29. doi:10.5155/eurjchem.9.1.22-29.1671
Turan, N.; Buldurun, K. Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex. Eur. J. Chem. 2018, 9(1), 22-29. doi:10.5155/eurjchem.9.1.22-29.1671
Turan, N., & Buldurun, K. (2018). Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex. European Journal of Chemistry, 9(1), 22-29. doi:10.5155/eurjchem.9.1.22-29.1671
Turan, Nevin, & Kenan Buldurun. "Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex." European Journal of Chemistry [Online], 9.1 (2018): 22-29. Web. 3 Jun. 2023
Turan, Nevin, AND Buldurun, Kenan. "Synthesis, characterization and antioxidant activity of Schiff base and its metal complexes with Fe(II), Mn(II), Zn(II), and Ru(II) ions: Catalytic activity of ruthenium(II) complex" European Journal of Chemistry [Online], Volume 9 Number 1 (31 March 2018)

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