European Journal of Chemistry 2018, 9(1), 44-48. doi:10.5155/eurjchem.9.1.44-48.1679

Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction


Ibrahim Ali Radini (1) orcid , Sameh Ramadan El-Gogary (2) orcid , Mohamed Sabri Mostafa (3,*) orcid , Bander Alnagei (4) orcid , Mohammed Mudarbish (5) orcid , Shadad Dash (6) orcid

(1) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(2) Chemistry Department, Faculty of Science, Damietta University, New Damietta, 34518, Egypt
(3) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(4) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(5) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(6) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(*) Corresponding Author

Received: 28 Dec 2017, Accepted: 28 Jan 2018, Published: 31 Mar 2018

Abstract


Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.


Keywords


Ethanolamine; One pot reaction; Pyranoquinolinone; 4-Hydroxyquinolinone; Multicomponent reaction; Cinnamonitrile derivatives

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DOI: 10.5155/eurjchem.9.1.44-48.1679

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How to cite


Radini, I.; El-Gogary, S.; Mostafa, M.; Alnagei, B.; Mudarbish, M.; Dash, S. Eur. J. Chem. 2018, 9(1), 44-48. doi:10.5155/eurjchem.9.1.44-48.1679
Radini, I.; El-Gogary, S.; Mostafa, M.; Alnagei, B.; Mudarbish, M.; Dash, S. Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction. Eur. J. Chem. 2018, 9(1), 44-48. doi:10.5155/eurjchem.9.1.44-48.1679
Radini, I., El-Gogary, S., Mostafa, M., Alnagei, B., Mudarbish, M., & Dash, S. (2018). Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction. European Journal of Chemistry, 9(1), 44-48. doi:10.5155/eurjchem.9.1.44-48.1679
Radini, Ibrahim, Sameh Ramadan El-Gogary, Mohamed Sabri Mostafa, Bander Alnagei, Mohammed Mudarbish, & Shadad Dash. "Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction." European Journal of Chemistry [Online], 9.1 (2018): 44-48. Web. 16 Sep. 2019
Radini, Ibrahim, El-Gogary, Sameh, Mostafa, Mohamed, Alnagei, Bander, Mudarbish, Mohammed, AND Dash, Shadad. "Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction" European Journal of Chemistry [Online], Volume 9 Number 1 (31 March 2018)

DOI Link: https://doi.org/10.5155/eurjchem.9.1.44-48.1679

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