OPEN ACCESS | PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS
Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction
Ibrahim Ali Radini (1) , Sameh Ramadan El-Gogary (2) , Mohamed Sabri Mostafa (3,*) , Bander Alnagei (4) , Mohammed Mudarbish (5) , Shadad Dash (6)
(1) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(2) Chemistry Department, Faculty of Science, Damietta University, New Damietta, 34518, Egypt
(3) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(4) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(5) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(6) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(*) Corresponding Author
Received: 28 Dec 2017 | Revised: 27 Jan 2018 | Accepted: 28 Jan 2018 | Published: 31 Mar 2018 | Issue Date: March 2018
Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.
Links for Article
| | | | |
| | | | | | |
Article MetricsThis Abstract was viewed 494 times | PDF Article downloaded 219 times
Jazan University (Project no. 019-FS3), Jazan, 2079, Kingdom of Saudi Arabia.
. Asghari, S.; Ramezani, S.; Mohseni, M. Chin. Chem. Lett. 2014, 25, 431-434.
. Hassanin, H.; Ibrahim, M.; Alnamer, Y. Turk. J. Chem. 2012, 36, 682-699.
. Fujita, Y.; Oguri, H.; Oikawa, H. J. Antibiot. 2005, 58, 425-427.
. Chen, J. J.; Chen, P. H.; Liao, C. H.; Huang, S. Y.; Chen, I. S. J. Nat. Prod. 2007, 70, 1444-1448.
. Isaka, M.; Tanticharoen, M.; Kongsaeree, P.; Thebtaranonth, Y. J. Org. Chem. 2001, 66, 4803-4808.
. Magedov, V.; Madhuri, M.; Marcia, O.; Adriana, D.; Snezna, R.; Severine, V.; Wim, S.; Nikolai, E.; Pavel, U.; Eerik, E.; Erica, K.; Paul, T.; Mikhail, A.; Alexander, K. J. Med. Chem. 2008, 51(8), 2561-2570.
. Kamperdick, C.; Van, N. H.; Van Sung, T.; Adam, G. Phytochemistry 1999, 50, 177-181.
. Chen, I. S.; Wu, S. J.; Tsai, I. L.; Wu, T. S.; Pezzuto, J. M.; Lu, C.; Chai, H.; Suh, N.; Teng, M. J. Nat. Prod. 1994, 57, 1206-1211.
. Heiner, E. Molecules 2012, 17, 1074-1102.
. Bhupathi, R.; Madhu, B.; Devi, R.; Reddy, R.; Dubey, K. J. Heterocycl. Chem. 2016, 53(6), 1911-1916.
. Shehata, A. S.; Faida, H.; Moustafa, M. A.; Mashaly, M. M. J. Am. Sci. 2011, 7(11), 240-242.
. Kumar, N. V.; Rajendran, S. P. Heterocycl. Commun. 2004, 10, 289-294.
. Dodia, N.; Shah, A. Heterocycl. Commun. 2001, 7, 289-294.
How to cite
DOI Link: https://doi.org/10.5155/eurjchem.9.1.44-48.1679
| | | | |
| | | | | |
Save to Zotero Save to Mendeley
European Journal of Chemistry 2018, 9(1), 44-48 | doi: https://doi.org/10.5155/eurjchem.9.1.44-48.1679 | Get rights and content
- There are currently no refbacks.
Copyright (c) 2018 Authors
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).
© Copyright 2019 • Atlanta Publishing House LLC • All Right Reserved.
The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.
Copyright 2019 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 4614 Lavista road, Tucker, GA, 30084, USA. Registered in USA.