European Journal of Chemistry

Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction


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Ibrahim Ali Radini
Sameh Ramadan El-Gogary
Mohamed Sabri Mostafa
Bander Alnagei
Mohammed Mudarbish
Shadad Dash


Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.

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How to Cite
Radini, I. A.; El-Gogary, S. R.; Mostafa, M. S.; Alnagei, B.; Mudarbish, M.; Dash, S. Ecofriendly and Simple Synthesis of pyrano[3,2-c]quinolone in Water via an Efficient One-Pot Three-Component Reaction. Eur. J. Chem. 2018, 9, 44-48.

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[1]. Asghari, S.; Ramezani, S.; Mohseni, M. Chin. Chem. Lett. 2014, 25, 431-434.

[2]. Hassanin, H.; Ibrahim, M.; Alnamer, Y. Turk. J. Chem. 2012, 36, 682-699.

[3]. Fujita, Y.; Oguri, H.; Oikawa, H. J. Antibiot. 2005, 58, 425-427.

[4]. Chen, J. J.; Chen, P. H.; Liao, C. H.; Huang, S. Y.; Chen, I. S. J. Nat. Prod. 2007, 70, 1444-1448.

[5]. Isaka, M.; Tanticharoen, M.; Kongsaeree, P.; Thebtaranonth, Y. J. Org. Chem. 2001, 66, 4803-4808.

[6]. Magedov, V.; Madhuri, M.; Marcia, O.; Adriana, D.; Snezna, R.; Severine, V.; Wim, S.; Nikolai, E.; Pavel, U.; Eerik, E.; Erica, K.; Paul, T.; Mikhail, A.; Alexander, K. J. Med. Chem. 2008, 51(8), 2561-2570.

[7]. Kamperdick, C.; Van, N. H.; Van Sung, T.; Adam, G. Phytochemistry 1999, 50, 177-181.

[8]. Chen, I. S.; Wu, S. J.; Tsai, I. L.; Wu, T. S.; Pezzuto, J. M.; Lu, C.; Chai, H.; Suh, N.; Teng, M. J. Nat. Prod. 1994, 57, 1206-1211.

[9]. Heiner, E. Molecules 2012, 17, 1074-1102.

[10]. Bhupathi, R.; Madhu, B.; Devi, R.; Reddy, R.; Dubey, K. J. Heterocycl. Chem. 2016, 53(6), 1911-1916.

[11]. Shehata, A. S.; Faida, H.; Moustafa, M. A.; Mashaly, M. M. J. Am. Sci. 2011, 7(11), 240-242.

[12]. Kumar, N. V.; Rajendran, S. P. Heterocycl. Commun. 2004, 10, 289-294.

[13]. Dodia, N.; Shah, A. Heterocycl. Commun. 2001, 7, 289-294.

Supporting Agencies

Jazan University (Project no. 019-FS3), Jazan, 2079, Kingdom of Saudi Arabia.

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