Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction
Ibrahim Ali Radini (1) , Sameh Ramadan El-Gogary (2) , Mohamed Sabri Mostafa (3,*) , Bander Alnagei (4) , Mohammed Mudarbish (5) , Shadad Dash (6)
(1) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(2) Chemistry Department, Faculty of Science, Damietta University, New Damietta, 34518, Egypt
(3) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(4) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(5) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(6) Chemistry Department, Faculty of Science, Jazan University, Jazan, 2079, Kingdom of Saudi Arabia
(*) Corresponding Author
Received: 28 Dec 2017, Accepted: 28 Jan 2018, Published: 31 Mar 2018
Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.
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DOI Link: https://doi.org/10.5155/eurjchem.9.1.44-48.1679
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