European Journal of Chemistry

Ecofriendly and simple synthesis of pyrano[3,2-c]quinolone in water via an efficient one-pot three-component reaction

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Ibrahim Ali Radini
Sameh Ramadan El-Gogary
Mohamed Sabri Mostafa
Bander Alnagei
Mohammed Mudarbish
Shadad Dash

Abstract

Pyrano[3,2-c]quinolones are commonly found in alkaloids, manifesting diverse biological activities. In this work, 2-amino-6-methyl-5-oxo-4-substituted-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carbonitriles and ethyl 2-amino-4-(substituted)-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxylates have been synthesized efficiently from reaction of 4-hydroxy-1-methylquinolin-2(1H)-one, aldehydes and active methylene nitriles in one-pot three component reaction in aqueous medium, containing catalytic amount of ethanolamine resulting in 70-95% yields.


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Radini, I. A.; El-Gogary, S. R.; Mostafa, M. S.; Alnagei, B.; Mudarbish, M.; Dash, S. Ecofriendly and Simple Synthesis of pyrano[3,2-c]quinolone in Water via an Efficient One-Pot Three-Component Reaction. Eur. J. Chem. 2018, 9, 44-48.

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Supporting Agencies

Jazan University (Project no. 019-FS3), Jazan, 2079, Kingdom of Saudi Arabia.
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