Eco-friendly and simple synthesis of some non-natural flavones through chalcones

Mohammad Saidur Rahman; Sayeda Shakila Alam; Kamrunnahar Happy; Mohammad Mamun Hossain; Mohammad Khademul Islam; Foni Bushon Biswas

doi:10.5155/eurjchem.9.3.236-240.1732

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Published: Sep 30, 2018

DOI: https://doi.org/10.5155/eurjchem.9.3.236-240.1732

Keywords:

Iodine, Flavones, Chalcones, Sulfuric acid, Microwave chemistry, Conventional synthesis

Section

Research Article

Issue

Vol. 9 No. 3 (2018): September 2018

Dates

Received 2018-05-08
Accepted 2018-06-06
Published 2018-09-30

Mohammad Saidur Rahman

Department of Chemistry, Faculty of Mathematical and Physical Sciences, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

http://orcid.org/0000-0003-3747-2098

Sayeda Shakila Alam

Department of Chemistry, Faculty of Mathematical and Physical Sciences, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

http://orcid.org/0000-0001-6454-7118

Kamrunnahar Happy

Department of Chemistry, Faculty of Mathematical and Physical Sciences, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

http://orcid.org/0000-0002-0026-1855

Mohammad Mamun Hossain

Department of Chemistry, Faculty of Mathematical and Physical Sciences, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh

http://orcid.org/0000-0002-7712-2482

Mohammad Khademul Islam

Department of Chemistry, Faculty of Science, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh

http://orcid.org/0000-0002-3819-4977

Foni Bushon Biswas

Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh

http://orcid.org/0000-0002-0935-8530

Abstract

A distinctive feature of polyphenolics is the possession of biological properties such as antioxidant and antimicrobial activities. Simple synthesis and study about such important class of compounds and their analogs are very important to enhance the understanding of their role in human health and diseases. Accordingly, a series of chalcones (2a-f) have been synthesized by Claisen-Schmidt condensation reaction with required acetophenones and aromatic aldehydes in high yields. The conversion of chalcones to the corresponding flavones (1a-g) taking minimal amount of dimethyl sulfoxide with iodine in presence of sulfuric acid was carried out under microwave conditions in high yields.

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How to Cite

(1)

Rahman, M. S.; Alam, S. S.; Happy, K.; Hossain, M. M.; Islam, M. K.; Biswas, F. B. Eco-Friendly and Simple Synthesis of Some Non-Natural Flavones through Chalcones. Eur. J. Chem. 2018, 9, 236-240.

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Supporting Agencies

The Ministry of Science and Technology, Government of the People’s Republic of Bangladesh.

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