European Journal of Chemistry 2018, 9(3), 269-274. doi:10.5155/eurjchem.9.3.269-274.1751

Microwave assisted one pot conversion of aromatic aldehydes to nitriles


Yousef Mohammad Hijji (1,*) orcid , Rajeesha Rajan (2) orcid , Hani Darwish Tabba (3) orcid , Imad Ali Abu-Yousef (4) orcid , Said Mansour (5) orcid , Hamdi Ben Yahia (6) orcid

(1) Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar
(2) Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar
(3) Department of Chemistry and Earth Sciences, Qatar University, 2713, Doha, Qatar
(4) Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, 26666, Sharjah, United Arab Emirates
(5) Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, 34110 Doha, Qatar
(6) Qatar Environment and Energy Research Institute, Hamad Bin Khalifa University, Qatar Foundation, 34110 Doha, Qatar
(*) Corresponding Author

Received: 31 May 2018, Accepted: 28 Jul 2018, Published: 30 Sep 2018

Abstract


Nitriles are versatile organic precursors in organic synthesis and have numerous applications. An efficient microwave assisted method for conversion of aromatic aldehydes to the corresponding nitriles is reported. Aldehydes are readily converted to oxime followed by acetylation and acetic acid elimination to provide nitriles in good yields within minutes. The method proved to be efficient for the synthesis of aromatic and heterocyclic nitriles. The reaction proceeds smoothly by microwave at 150 °C for 5 minutes. The obtained products are isolated simply by filtration or extraction.


Keywords


Aldoxime; Aldehyde; Aryl nitrile; Microwave; Elimination; Hydroxylamine

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DOI: 10.5155/eurjchem.9.3.269-274.1751

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[1]. Hong Meng, Sen Gao, Meiming Luo, Xiaoming Zeng
Iron and Phenol Co-Catalysis for Rapid Synthesis of Nitriles under Mild Conditions
European Journal of Organic Chemistry  2019(28), 4617, 2019
DOI: 10.1002/ejoc.201900831
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How to cite


Hijji, Y.; Rajan, R.; Tabba, H.; Abu-Yousef, I.; Mansour, S.; Yahia, H. Eur. J. Chem. 2018, 9(3), 269-274. doi:10.5155/eurjchem.9.3.269-274.1751
Hijji, Y.; Rajan, R.; Tabba, H.; Abu-Yousef, I.; Mansour, S.; Yahia, H. Microwave assisted one pot conversion of aromatic aldehydes to nitriles. Eur. J. Chem. 2018, 9(3), 269-274. doi:10.5155/eurjchem.9.3.269-274.1751
Hijji, Y., Rajan, R., Tabba, H., Abu-Yousef, I., Mansour, S., & Yahia, H. (2018). Microwave assisted one pot conversion of aromatic aldehydes to nitriles. European Journal of Chemistry, 9(3), 269-274. doi:10.5155/eurjchem.9.3.269-274.1751
Hijji, Yousef, Rajeesha Rajan, Hani Darwish Tabba, Imad Ali Abu-Yousef, Said Mansour, & Hamdi Ben Yahia. "Microwave assisted one pot conversion of aromatic aldehydes to nitriles." European Journal of Chemistry [Online], 9.3 (2018): 269-274. Web. 16 Sep. 2019
Hijji, Yousef, Rajan, Rajeesha, Tabba, Hani, Abu-Yousef, Imad, Mansour, Said, AND Yahia, Hamdi. "Microwave assisted one pot conversion of aromatic aldehydes to nitriles" European Journal of Chemistry [Online], Volume 9 Number 3 (30 September 2018)

DOI Link: https://doi.org/10.5155/eurjchem.9.3.269-274.1751

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