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Synthesis, crystal structure and in vitro anticancer studies of two bis(8-quinolinolato-N,O)-platinum(II) complexes
Hong Chen (1,*)
, Mingguo Liu (2) (1) Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, P. R. China
(2) Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, P. R. China
(*) Corresponding Author
Received: 06 Nov 2018 | Revised: 15 Dec 2018 | Accepted: 18 Dec 2018 | Published: 31 Mar 2019 | Issue Date: March 2019
Abstract
Two bis(8-quinolinolato-N,O)-platinum(II) complexes, C18H12N2O2Pt (1) and C20H16N2O2Pt (2), were synthesized and characterized by FT-IR, elementary analysis and X-ray single crystal diffraction. Complex 1 crystallizes in monoclinic, space group P21/c with a = 9.3413(7), b = 10.3893(9), c = 14.8495(12) Å, β = 100.574(7)°, V = 1416.7(2) Å3. Complex 2 crystallizes in monoclinic, space group P21/n with a = 9.5115(11), b = 15.5692(18), c = 16.720(2) Å, β = 94.544(2)°, V = 2468.3(5) Å3. Intermolecular C-H···O hydrogen bonding interactions, as well as Pt···Pt and π-π stacking interactions, help to stabilize the crystal structures. The preliminary in vitro anticancer activity of complexes 1 and 2 and the corresponding ligands (L1 and L2) were investigated using human cervical (Hela) and hepatocellular carcinoma (Hep-G2) cancer cell lines. The platinum(II) complexes can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both ligands.
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DOI: 10.5155/eurjchem.10.1.37-44.1814
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Analytical & Testing Center of China Three Gorges University, Yichang 443002, P. R. China.
Citations
[1]. Quang Trung Nguyen, Phuong Nam Pham Thi, Nguyen Van Tuyen, Damião Pergentino de Sousa
Synthesis, Spectral Characterization, and In Vitro Cytotoxicity of Some Fe(III) Complexes Bearing Unsymmetrical Salen-Type Ligands Derived from 2-Hydroxynaphthaldehyde and Substituted Salicylaldehydes
Journal of Chemistry 2021, 1, 2021
DOI: 10.1155/2021/8028064
[2]. Rohini Gupta, Vijay Luxami, Kamaldeep Paul
Insights of 8-hydroxyquinolines: A novel target in medicinal chemistry
Bioorganic Chemistry 108, 104633, 2021
DOI: 10.1016/j.bioorg.2021.104633
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