Synthesis, crystal structure and in vitro anticancer studies of two bis(8-quinolinolato-N,O)-platinum(II) complexes

Hong Chen; Mingguo Liu

doi:10.5155/eurjchem.10.1.37-44.1814

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Published: Mar 31, 2019

DOI: https://doi.org/10.5155/eurjchem.10.1.37-44.1814

Keywords:

DFT calculations, Crystal structure, Anticancer activity, 8-Hydroxyquinoline, Platinum(II) complexes, 8-Hydroxy-2-methylquinoline

Section

Research Article

Issue

Vol. 10 No. 1 (2019): March 2019

Dates

Received 2018-11-06
Accepted 2018-12-18
Published 2019-03-31

Hong Chen

Key Laboratory of Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, P. R. China

http://orcid.org/0000-0002-8415-7333

Mingguo Liu

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, P. R. China

http://orcid.org/0000-0003-2686-3034

Abstract

Two bis(8-quinolinolato-N,O)-platinum(II) complexes, C₁₈H₁₂N₂O₂Pt (1) and C₂₀H₁₆N₂O₂Pt (2), were synthesized and characterized by FT-IR, elementary analysis and X-ray single crystal diffraction. Complex 1 crystallizes in monoclinic, space group P2₁/c with a = 9.3413(7), b = 10.3893(9), c = 14.8495(12) Å, β = 100.574(7)°, V = 1416.7(2) Å³. Complex 2 crystallizes in monoclinic, space group P2₁/n with a = 9.5115(11), b = 15.5692(18), c = 16.720(2) Å, β = 94.544(2)°, V = 2468.3(5) Å³. Intermolecular C-H···O hydrogen bonding interactions, as well as Pt···Pt and π-π stacking interactions, help to stabilize the crystal structures. The preliminary in vitro anticancer activity of complexes 1 and 2 and the corresponding ligands (L1 and L2) were investigated using human cervical (Hela) and hepatocellular carcinoma (Hep-G2) cancer cell lines. The platinum(II) complexes can greatly inhibit the cell proliferation and show stronger cytotoxic activities against the tested cancer cell lines than both ligands.

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Chen, H.; Liu, M. Synthesis, Crystal Structure and in Vitro Anticancer Studies of Two bis(8-Quinolinolato-N,O)-platinum(II) Complexes. Eur. J. Chem. 2019, 10, 37-44.

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Supporting Agencies

Analytical & Testing Center of China Three Gorges University, Yichang 443002, P. R. China.

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