European Journal of Chemistry 2019, 10(2), 131-138 | doi: https://doi.org/10.5155/eurjchem.10.2.131-138.1858 | Get rights and content

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Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone


Irfan Shaikh (1) orcid , Aliasgar Vohra (2) orcid , Ranjitsinh Devkar (3) orcid , Rajendrasinh Jadeja (4,*) orcid

(1) Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India
(2) Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India
(3) Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India
(4) Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India
(*) Corresponding Author

Received: 29 Mar 2019 | Revised: 09 May 2019 | Accepted: 10 May 2019 | Published: 30 Jun 2019 | Issue Date: June 2019

Abstract


Novel acyl pyrazolone and thio-Schiff base of acyl pyrazolone ligand HL (2-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene) hydrazine-1-carbothioamide) has been synthesised and characterized by FT-IR and 1H NMR techniques. This unusual coordinated complex [Zn(L)(CH3C00)(H2O)]CH3CH2OH has been synthesized and characterized by FT-IR, thermogravimetric analysis (TGA), UV-Vis spectroscopy and single crystal X-ray diffraction. 1H NMR confirms the structure of the thio-Schiff base used in the study. The structural data reveal that mononuclear Zn(II)complex has distorted square pyramidal geometry. S-S interaction, Inter molecular and intra molecular H-Bond found in crystal packing of the complex. The complex has been screened for MTT assay against A549 cell lines. The Zn(II) complex is cytotoxic against the screened cell line at low concentration.

 


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Keywords


ONS donors; Cytotoxicity; Zn(II) complex; Thio-Schiff base; Single crystal structure; Acyl pyrazolone derivatives

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DOI: 10.5155/eurjchem.10.2.131-138.1858

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Funding information


Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India.

Citations

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[3]. Irfan Shaikh, R.N. Jadeja, Rajesh Patel
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[4]. Joshua Ayoola Obaleye, Misitura Lawal, Rajendrasinh N. Jadeja, Vivek Kumar Gupta, Ginikachukwu Grace Nnabuike, Mercy Oluwaseyi Bamigboye, Hetal Roy, Olaniyi Kamil Yusuff, Poonam Bhagariya
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Supporting information


The Supplementary Material for this article can be found online at: Supplementary files

How to cite


Shaikh, I.; Vohra, A.; Devkar, R.; Jadeja, R. Eur. J. Chem. 2019, 10(2), 131-138. doi:10.5155/eurjchem.10.2.131-138.1858
Shaikh, I.; Vohra, A.; Devkar, R.; Jadeja, R. Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone. Eur. J. Chem. 2019, 10(2), 131-138. doi:10.5155/eurjchem.10.2.131-138.1858
Shaikh, I., Vohra, A., Devkar, R., & Jadeja, R. (2019). Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone. European Journal of Chemistry, 10(2), 131-138. doi:10.5155/eurjchem.10.2.131-138.1858
Shaikh, Irfan, Aliasgar Vohra, Ranjitsinh Devkar, & Rajendrasinh Jadeja. "Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone." European Journal of Chemistry [Online], 10.2 (2019): 131-138. Web. 11 Dec. 2023
Shaikh, Irfan, Vohra, Aliasgar, Devkar, Ranjitsinh, AND Jadeja, Rajendrasinh. "Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone" European Journal of Chemistry [Online], Volume 10 Number 2 (30 June 2019)

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