European Journal of Chemistry

Synthesis, characterization, structural features and cytotoxicity of innovative zinc(II) complex derived from ONS-donor thio-Schiff base of acyl pyrazolone

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Published: Jun 30, 2019
DOI: https://doi.org/10.5155/eurjchem.10.2.131-138.1858
Keywords:
ONS donors, Cytotoxicity, Zn(II) complex, Thio-Schiff base, Single crystal structure, Acyl pyrazolone derivatives
Section
Research Article
Issue
Vol. 10 No. 2 (2019): June 2019
Dates
Received 2019-03-29
Accepted 2019-05-10
Published 2019-06-30
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Irfan Shaikh
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India
http://orcid.org/0000-0002-0403-2566
Aliasgar Vohra
Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India
http://orcid.org/0000-0002-4845-084X
Ranjitsinh Devkar
Department of Zoology, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390 002, India
http://orcid.org/0000-0002-9863-7418
Rajendrasinh Jadeja
Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India
http://orcid.org/0000-0002-2228-8653

Abstract

Novel acyl pyrazolone and thio-Schiff base of acyl pyrazolone ligand HL (2-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene) hydrazine-1-carbothioamide) has been synthesised and characterized by FT-IR and 1H NMR techniques. This unusual coordinated complex [Zn(L)(CH3C00)(H2O)]CH3CH2OH has been synthesized and characterized by FT-IR, thermogravimetric analysis (TGA), UV-Vis spectroscopy and single crystal X-ray diffraction. 1H NMR confirms the structure of the thio-Schiff base used in the study. The structural data reveal that mononuclear Zn(II)complex has distorted square pyramidal geometry. S-S interaction, Inter molecular and intra molecular H-Bond found in crystal packing of the complex. The complex has been screened for MTT assay against A549 cell lines. The Zn(II) complex is cytotoxic against the screened cell line at low concentration.

 


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Shaikh, I.; Vohra, A.; Devkar, R.; Jadeja, R. Synthesis, Characterization, Structural Features and Cytotoxicity of Innovative zinc(II) Complex Derived from ONS-Donor Thio-Schiff Base of Acyl Pyrazolone. Eur. J. Chem. 2019, 10, 131-138.

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References

[1]. Zhang, Y. P.; Li, Y.; Xu, G. C.; Li, J. Y.; Luo, H. Y.; Li, J. Y.; Zhang, L.; Jia, D. Z. Appl. Organomet. Chem. 2019, 33(3), 4668-4672.

[2]. Li, H.; Xu, G. C.; Zhang, L.; Guo, J. X.; Jia, D. Z. Polyhedron 2013, 55, 209-215.
https://doi.org/10.1016/j.poly.2013.03.024

[3]. Parmar, N.; Teraiya, S.; Patel, R.; Barad, H.; Jajda, H.; Thakkar, V. J. Saudi Chem. Soc. 2015, 19(1), 36-41.
https://doi.org/10.1016/j.jscs.2011.12.014

[4]. Liu, L.; Jia, D. Z.; Ji, Y. L.; Yu, K. B. J. Photochem. Photobiol. A 2003, 154(2), 117-122.
https://doi.org/10.1016/S1010-6030(02)00321-0

[5]. Joseph; V. A.; Vyas, K. M.; Pandya, J. H.; Gupta, V. K.; Jadeja, R. N. J. Coord. Chem. 2013, 66(6), 1094-1106.
https://doi.org/10.1080/00958972.2013.776164

[6]. Nakum, K.; Jadeja, R. N. Z. Naturforsch. B 2018, 73(10), 677-747.
https://doi.org/10.1515/znb-2018-0117

[7]. Lo, K. Inorganic and organometallic transition metal complexeswith biological molecules and living cells, Academic Press: Hong Kong, 2017.

[8]. Novak, P.; Piculjan, K.; Biljan, T.; Hrenar, T.; Cindric, M.; Rubcic, M.; Meic, Z. Croat. Chem. Acta 2007, 80, 575-581.

[9]. Campbell, M. J. M.; Morrison, E.; Rogers, V.; Baker, P. K. Polyhedron 1987, 6(8), 1703-1705.

[10]. Lu, J.; Zhang, L.; Liu, L.; Liu, G.; Jia, D.; Wu, D.; Xu, G. Spectrochim. Acta A 2008, 71(3), 1036-1041.
https://doi.org/10.1016/j.saa.2008.02.048

[11]. Xu, G. C.; Zhang, L.; Zhang, Y. H.; Guo, J. X.; Shi, M. Q.; Jia, D. Z. CrystEngComm 2013, 15(15), 2873-2880.
https://doi.org/10.1039/c3ce27049a

[12]. Vyas, K. M.; Joshi, R. G.; Jadeja, R. N.; Prabha, C. R.; Gupta, V. K. Spectrochim. Acta A 2011, 84, 256-268.
https://doi.org/10.1016/j.saa.2011.09.039

[13]. Yadav, R. J.; Vyas, K. M.; Jadeja, R. N. J. Coord. Chem. 2010, 63(10), 1820-1831.
https://doi.org/10.1080/00958972.2010.489946

[14]. Singh, R. V.; Chaudhary, P.; Chauhan, S.; Swami, M. Spectrochim. Acta A 2009, 72(2), 260-268.
https://doi.org/10.1016/j.saa.2008.09.017

[15]. Abou-Hussein, A. A.; Linert, W. Spectrochim. Acta A 2014, 117, 763-771.
https://doi.org/10.1016/j.saa.2013.06.078

[16]. Bal-Demirci, T.; Sahin, M.; Kondakci, E.; Ozyurek, M.; Ulkuseven, B.; Apak, R. Spectrochim. Acta A 2015, 138, 866-872.
https://doi.org/10.1016/j.saa.2014.10.088

[17]. Datta, S.; Seth, D. K.; Butcher, R. J.; Bhattacharya, S. Inorganica Chim. Acta 2011, 377(1), 120-128.
https://doi.org/10.1016/j.ica.2011.08.005

[18]. Jadeja, R. N.; Chhatrola, M.; Gupta, V. K. Polyhedron 2013, 63, 117-126.
https://doi.org/10.1016/j.poly.2013.07.018

[19]. University of Gottingen. G. M. Sheldrick, SHELXS97 and SHELXL97; Germany, 1997.

[20]. Johnson, C. K. ORTEP II; Report ORNL-5138;Oak Ridge, TN, 1976.

[21]. Farrugia, L. J. J. Appl. Crystallogr. 1997, 30, 565-566.
https://doi.org/10.1107/S0021889897005025

[22]. Spek, A. L. PLATON for Windows,September.; University of Utrecht: Netherlands, 1999.

[23]. Nardelli, M. J. Appl. Crystallogr. 1995, 28(5), 659-665.
https://doi.org/10.1107/S0021889895007138

[24]. Malik, S.; Kumari, M.; Sharma, D. J. Indian Chem. Soc. 2010, 87, 539-549.

[25]. Korosec, R. C.; Bukovec, P. Thermochim. Acta 2004, 410, 65-71.
https://doi.org/10.1016/S0040-6031(03)00373-3

[26]. Turkkan, B.; Ulkuseven, B.; Eroglu, E. Phosphorus, Sulfur Silicon Relat. Elem. 2015, 190(1), 53-65.
https://doi.org/10.1080/10426507.2014.919502

[27]. Stacy, A. E.; Palanimuthu, D.; Bernhardt, P. V; Kalinowski, D. S.; Jansson, P. J.; Richardson, D. R. J. Med. Chem. 2016, 59(10), 4965-4984.
https://doi.org/10.1021/acs.jmedchem.6b00238

[28]. Field, J. B.; Dolendo, E. C.; Mireles, A.; Ershoff, B. H. Cancer Res. 1966, 26(7), 1371-1375.

[29]. Vyas, K. M.; Jadeja, R. N.; Patel, D.; Devkar, R. V; Gupta, V. K. Polyhedron 2014, 80, 20-33.
https://doi.org/10.1016/j.poly.2013.12.037

[30]. Vyas, K. M.; Jadeja, R. N.; Patel, D.; Devkar, R. V; Gupta, V. K. Polyhedron 2013, 65, 262-274.
https://doi.org/10.1016/j.poly.2013.08.051

[31]. Thounaojam, M. C.; Jadeja, R. N.; Valodkar, M.; Nagar, P. S.; Devkar, R. V; Thakore, S. Food Chem. Toxicol. 2011, 49(11), 2990-2996.
https://doi.org/10.1016/j.fct.2011.07.055

[32]. Upadhyay, K. K.; Jadeja, R. N.; Thadani, J. M.; Joshi, A.; Vohra, A.; Mevada, V.; Patel, R.; Khurana, S.; Devkar, R. V. Toxicol. Appl. Pharmacol. 2018, 360, 99-108.
https://doi.org/10.1016/j.taap.2018.09.034

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Department of Chemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara-390002, India.
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