European Journal of Chemistry 2020, 11(1), 21-29 | doi: https://doi.org/10.5155/eurjchem.11.1.21-29.1950 | Get rights and content






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Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)


Iyad Darweesh Al-Kashef (1) orcid , Salman Mostafa Saadeh (2) orcid , Khalid Ibrahim Abed Almonem (3) orcid , Nasser Mohammed Abu Ghalwa (4) orcid , Hazem Mohammed Abu Shawish (5,*) orcid

(1) Chemistry Department, Al-Azhar University, Gaza, P.O Box 1277, Palestine
(2) Chemistry Department, The Islamic University of Gaza, Gaza, P.O Box 108, Palestine
(3) Chemistry Department, Al-Azhar University, Gaza, P.O Box 1277, Palestine
(4) Chemistry Department, Al-Azhar University, Gaza, P.O Box 1277, Palestine
(5) Chemistry Department, College of Sciences, Al-Aqsa University, Gaza, P.O Box 4051, Palestine
(*) Corresponding Author

Received: 18 Dec 2019 | Revised: 26 Jan 2020 | Accepted: 27 Jan 2020 | Published: 31 Mar 2020 | Issue Date: March 2020

Abstract


Accurate, rapid and inexpensive determination of gemcitabine, an anticancer drug, is of high interest. This manuscript describes the use of potentiometric sensors as a basis for this work given their known attractive characteristics that meet our needs. Potentiometric sensors were comprised of carbon paste S1, coated wire S2 and PVC membrane S3, of gemcitabine (an anticancer drug) were fabricated, studied and evaluated. The calibration plots for these electrodes showed a Nernstian slope of 58.4±0.3, 59.5±0.3 and 58.3±0.3 mV per decade with the limit of detection: 6.50×10-5, 7.20×10-5 and 4.60×10-5 for sensors S1, S2 and S3, respectively. The electrodes have a short and stable response time of ~5 seconds and good reproducibility in a pH range of 2.5-9.5. The present sensors show distinct selectivity toward the drug ion in comparison to several inorganic ions, sugars, amino acids and some common drug excipients. Gemcitabine was determined successfully in ampoules and urine using these sensors by the calibration curve method.


Keywords


Gemcitabine; Anticancer drug; Ion-selective electrode; Carbon paste electrode; PVC membrane electrode; Solid-contact ion-selective electrodes

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DOI: 10.5155/eurjchem.11.1.21-29.1950

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How to cite


Al-Kashef, I.; Saadeh, S.; Almonem, K.; Ghalwa, N.; Shawish, H. Eur. J. Chem. 2020, 11(1), 21-29. doi:10.5155/eurjchem.11.1.21-29.1950
Al-Kashef, I.; Saadeh, S.; Almonem, K.; Ghalwa, N.; Shawish, H. Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine). Eur. J. Chem. 2020, 11(1), 21-29. doi:10.5155/eurjchem.11.1.21-29.1950
Al-Kashef, I., Saadeh, S., Almonem, K., Ghalwa, N., & Shawish, H. (2020). Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine). European Journal of Chemistry, 11(1), 21-29. doi:10.5155/eurjchem.11.1.21-29.1950
Al-Kashef, Iyad, Salman Mostafa Saadeh, Khalid Ibrahim Abed Almonem, Nasser Mohammed Abu Ghalwa, & Hazem Mohammed Abu Shawish. "Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)." European Journal of Chemistry [Online], 11.1 (2020): 21-29. Web. 4 Jun. 2020
Al-Kashef, Iyad, Saadeh, Salman, Almonem, Khalid, Ghalwa, Nasser, AND Shawish, Hazem. "Fabrication and evaluation of potentiometric sensors of an anticancer drug (Gemcitabine)" European Journal of Chemistry [Online], Volume 11 Number 1 (31 March 2020)

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DOI Link: https://doi.org/10.5155/eurjchem.11.1.21-29.1950

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