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Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors
Dina Bakhotmah (1)
, Fatimah Alotaibi (2,*) (1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, 71941, Saudi Arabia
(*) Corresponding Author
Received: 04 Apr 2020 | Revised: 16 May 2020 | Accepted: 29 May 2020 | Published: 30 Sep 2020 | Issue Date: September 2020
Abstract
New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15.
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DOI: 10.5155/eurjchem.11.3.198-205.1988
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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia.
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DOI Link: https://doi.org/10.5155/eurjchem.11.3.198-205.1988
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