

Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors
Dina Bakhotmah (1)


(1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, 71941, Saudi Arabia
(*) Corresponding Author
Received: 04 Apr 2020 | Revised: 16 May 2020 | Accepted: 29 May 2020 | Published: 30 Sep 2020 | Issue Date: September 2020
Abstract
New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15.
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DOI: 10.5155/eurjchem.11.3.198-205.1988
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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia.
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