European Journal of Chemistry 2020, 11(3), 198-205 | doi: https://doi.org/10.5155/eurjchem.11.3.198-205.1988 | Get rights and content

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Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors


Dina Bakhotmah (1) orcid , Fatimah Alotaibi (2,*) orcid

(1) Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia
(2) Department of Chemistry, Faculty of Science, Tabuk University, Tabuk, 71941, Saudi Arabia
(*) Corresponding Author

Received: 04 Apr 2020 | Revised: 16 May 2020 | Accepted: 29 May 2020 | Published: 30 Sep 2020 | Issue Date: September 2020

Abstract


New fluorine-substituted polyfunctional pyrimido-[1,2-b]-[1,2,4]triazines and [1,3,5]-triazino[1,2-b]-[1,2,4]triazines were synthesized via the reaction between 3-amino-6-(2-aminophenyl)-1,2,4-triazin-5(2H)-one with polyfunctional oxygen/sulfur/nitrogen reagents under different conditions. Structures of the target compounds were deduced by elemental analysis and spectral measurements (IR, 1H/13C NMR, and mass spectra). According to the obtained inhibitor assay results, the inhibition activity of the new fluorine-substituted 1,2,4-triazines toward CDK2 decreased in the order of compounds 3 > 8 > 9 > 6 > 13 > 15.


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Keywords


Synthesis; 1,2,4-Triazine; Pyrimido-[1,2-b]-[1,2,4]triazine; [1,3,5]-Triazino[1,2-b]-[1,2,4]triazine; CDK2 enzymatic inhibitors evaluation; Fluorinated fused heterocyclic systems

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DOI: 10.5155/eurjchem.11.3.198-205.1988

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Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21551, Saudi Arabia.

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How to cite


Bakhotmah, D.; Alotaibi, F. Eur. J. Chem. 2020, 11(3), 198-205. doi:10.5155/eurjchem.11.3.198-205.1988
Bakhotmah, D.; Alotaibi, F. Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors. Eur. J. Chem. 2020, 11(3), 198-205. doi:10.5155/eurjchem.11.3.198-205.1988
Bakhotmah, D., & Alotaibi, F. (2020). Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors. European Journal of Chemistry, 11(3), 198-205. doi:10.5155/eurjchem.11.3.198-205.1988
Bakhotmah, Dina, & Fatimah Alotaibi. "Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors." European Journal of Chemistry [Online], 11.3 (2020): 198-205. Web. 4 Jun. 2023
Bakhotmah, Dina, AND Alotaibi, Fatimah. "Synthesis and pharmacological evaluation of new fluorine substituted pyrimido[1,2-b][1,2,4]triazines and [1,3,5]-triazino-[1,2-b][1,2,4]triazines derived as CDK2 potential inhibitors" European Journal of Chemistry [Online], Volume 11 Number 3 (30 September 2020)

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