European Journal of Chemistry 2020, 11(3), 206-212 | doi: https://doi.org/10.5155/eurjchem.11.3.206-212.1992 | Get rights and content

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FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction


Thalishetti Krishna (1) orcid , Eppakayala Laxminarayana (2,*) orcid , Dipak Kalita (3) orcid

(1) Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India
(2) Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, Hyderabad 501301, Telangana, India
(3) Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India
(*) Corresponding Author

Received: 02 May 2020 | Revised: 01 Jun 2020 | Accepted: 06 Jun 2020 | Published: 30 Sep 2020 | Issue Date: September 2020

Abstract


A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction. These reactions proceed at low-catalyst loadings with high functional group tolerance under mild conditions. This method provides efficient reusability of the catalyst and good to excellent yields of the products, making the protocol more attractive, economical, and environmentally benign. FeF3 is an attractive catalyst for the Biginelli reaction because of its high acidity, thermal stability and water tolerance.


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Keywords


FeF3; Green chemistry; Biginelli reaction; One-pot synthesis; Dihydropyrimidines; Multicomponent reactions

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DOI: 10.5155/eurjchem.11.3.206-212.1992

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Funding information


Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India.

Citations

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[1]. Y. S. Thakare
Green Synthesis of Dihydropyrimidinone Derivatives and Study of Physicochemical Properties and Antimicrobial Activity
International Journal of Advanced Research in Science, Communication and Technology  , 237, 2021
DOI: 10.48175/IJARSCT-2383
/

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How to cite


Krishna, T.; Laxminarayana, E.; Kalita, D. Eur. J. Chem. 2020, 11(3), 206-212. doi:10.5155/eurjchem.11.3.206-212.1992
Krishna, T.; Laxminarayana, E.; Kalita, D. FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction. Eur. J. Chem. 2020, 11(3), 206-212. doi:10.5155/eurjchem.11.3.206-212.1992
Krishna, T., Laxminarayana, E., & Kalita, D. (2020). FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction. European Journal of Chemistry, 11(3), 206-212. doi:10.5155/eurjchem.11.3.206-212.1992
Krishna, Thalishetti, Eppakayala Laxminarayana, & Dipak Kalita. "FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction." European Journal of Chemistry [Online], 11.3 (2020): 206-212. Web. 10 Dec. 2023
Krishna, Thalishetti, Laxminarayana, Eppakayala, AND Kalita, Dipak. "FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction" European Journal of Chemistry [Online], Volume 11 Number 3 (30 September 2020)

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