European Journal of Chemistry

FeF3 as a green catalyst for the synthesis of dihydropyrimidines via Biginelli reaction

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Published: Sep 30, 2020
DOI: https://doi.org/10.5155/eurjchem.11.3.206-212.1992
Keywords:
FeF3, Green chemistry, Biginelli reaction, One-pot synthesis, Dihydropyrimidines, Multicomponent reactions
Section
Research Article
Issue
Vol. 11 No. 3 (2020): September 2020
Dates
Received 2020-05-02
Accepted 2020-06-06
Published 2020-09-30
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Main Article Content

Thalishetti Krishna
Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India
http://orcid.org/0000-0002-8548-7545
Eppakayala Laxminarayana
Sreenidhi Institute of Science and Technology (Autonomous), Ghatkesar, Hyderabad 501301, Telangana, India
http://orcid.org/0000-0003-4465-042X
Dipak Kalita
Technology Development Centre, Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India
http://orcid.org/0000-0001-8421-9357

Abstract

A facile and highly efficient FeF3-catalyzed method has been developed for the direct synthesis of functionalized dihydropyrimidines from readily available starting materials via Biginelli reaction. These reactions proceed at low-catalyst loadings with high functional group tolerance under mild conditions. This method provides efficient reusability of the catalyst and good to excellent yields of the products, making the protocol more attractive, economical, and environmentally benign. FeF3 is an attractive catalyst for the Biginelli reaction because of its high acidity, thermal stability and water tolerance.


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Krishna, T.; Laxminarayana, E.; Kalita, D. FeF3 As a Green Catalyst for the Synthesis of Dihydropyrimidines via Biginelli Reaction. Eur. J. Chem. 2020, 11, 206-212.

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Dr. Reddy’s Laboratories Limited, Hyderabad 500049, India.
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