European Journal of Chemistry 2020, 11(4), 280-284 | doi: https://doi.org/10.5155/eurjchem.11.4.280-284.2010 | Get rights and content

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Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies


Vaishali Yogesh Londhe (1,*) orcid , Sreevidya Ramesh Krishnan (2) orcid

(1) Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle West, Mumbai, Maharashtra 400056, India
(2) Department of Pharmaceutics, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Vile Parle West, Mumbai, Maharashtra 400056, India
(*) Corresponding Author

Received: 22 Jul 2020 | Revised: 03 Sep 2020 | Accepted: 14 Sep 2020 | Published: 31 Dec 2020 | Issue Date: December 2020

Abstract


Ziprasidone (ZPR) is an antipsychotic agent having less solubility. It is used for the treatment of schizophrenia. Complexation of hydrophobic drugs with cyclodextrins leads to enhanced solubility and dissolution. In this study, inclusion complexes were prepared by different methods, using ZPR, β-cyclodextrin (β-CD), and different auxiliary agents like hydrophilic polymer and hydroxy acid (1:1:0.5) to improve the aqueous solubility. The characterization of the ternary complexes was carried out using solubility study, Differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), Fourier transformation infrared spectroscopy (FT-IR) and in vitro dissolution studies. DSC, XRD, and FT-IR studies showed interaction in drug, cyclodextrin, and auxiliary agents which are confirmed by enhancement of solubility and dissolution. Spray-dried dispersion showed less crystallinity and higher solubility as compared to the kneading method for both citric acid and Lutrol® F-68. Thus, the investigation concludes that the presence of the auxiliary agent has a synergistic action on complexation with cyclodextrin, which helps to modify the physicochemical properties of the drug.


Keywords


Ziprasidone; β-Cyclodextrin; IR spectroscopy; X-ray diffraction; Ternary complexes; Solubility enhancement

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DOI: 10.5155/eurjchem.11.4.280-284.2010

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How to cite


Londhe, V.; Krishnan, S. Eur. J. Chem. 2020, 11(4), 280-284. doi:10.5155/eurjchem.11.4.280-284.2010
Londhe, V.; Krishnan, S. Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies. Eur. J. Chem. 2020, 11(4), 280-284. doi:10.5155/eurjchem.11.4.280-284.2010
Londhe, V., & Krishnan, S. (2020). Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies. European Journal of Chemistry, 11(4), 280-284. doi:10.5155/eurjchem.11.4.280-284.2010
Londhe, Vaishali, & Sreevidya Ramesh Krishnan. "Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies." European Journal of Chemistry [Online], 11.4 (2020): 280-284. Web. 25 Jul. 2021
Londhe, Vaishali, AND Krishnan, Sreevidya. "Effect of inclusion of citric acid and Lutrol® F-68 on ziprasidone and β-cyclodextrin complexation: Characterization, solubility and dissolution studies" European Journal of Chemistry [Online], Volume 11 Number 4 (31 December 2020)

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