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Quick and simultaneous determination of caffeine and taurine in beverages using UPLC-ESI-MS
Mohd Aftab Alam (1,*)
, Rayan Saud Al-Arifi (2) , Abdulaziz Abdullah Al-Qarni (3) , Abdullah Shaya Al-Dosseri (4) , Fahad Ibrahim Al-Jenoobi (5) (1) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
(2) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
(3) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
(4) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
(5) Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
(*) Corresponding Author
Received: 26 Aug 2020 | Revised: 11 Oct 2020 | Accepted: 07 Dec 2020 | Published: 31 Mar 2021 | Issue Date: March 2021
Abstract
A rapid UPLC-ESI-MS method was developed for simultaneous determination of caffeine and taurine in beverages (energy drinks and soft drinks). The molecular ions of caffeine and taurine were identified in single ion recording mode at m/z 194.98 and 125.86, respectively. The mass spectrometer parameters were optimized as: capillary voltage 3.0 kV, cone voltage 35 V, extractor 3 V, RF Lens 0.1 V, source temperature 150 °C, desolvation temperature 350 °C, nitrogen 600 L/h, LMR1 7.9, HMR1 15.2, IE1 0.30. The mobile phase comprising methanol (0.1% formic acid) (A) and water (5 mM ammonium acetate) (B) was used in gradient mode. The mobile phase components A and B were pumped in 80:20 (v:v) ratio from 0-0.44 min, and then 100% of component A was pumped between 0.45-0.68 min, and at 0.69 min the composition was returned to 80:20 (v:v) ratio of A and B till 2.0 min. Caffeine and taurine were eluted at 0.46 and 0.43 min, respectively. The samples of energy drinks and soft drinks were diluted in a solvent system comprising methanol and water in 80:20 (v:v) ratio. Our investigations showed that soft drinks SD1 and SD2 have 88.8±4.2% and 110.7±3.6% (w:w) caffeine of their labeled claim. The caffeine content in energy drink brands ED1, ED2, ED3, and ED4 was 76.9±2.5, 65.6±3.4, 88.1±12.6, and 89.1±2.8% (w:w) of labeled claims, respectively. While taurine content in ED1, ED2, ED3, and ED4 was 86.5±8.4, 81.3±27.5, 101.9±4.8, and 97.1±0.3% (w:w) of labeled claim, respectively.
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DOI: 10.5155/eurjchem.12.1.18-22.2036
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Research Center of College of Pharmacy and Deanship of Scientific Research, King Saud University, Riyadh, 11451, The Kingdom of Saudi Arabia
Citations
[1]. Wasim Ahmad, Mohammad Yusuf, Ayaz Ahmad, Yousif Amin Hassan, Mohd Amir, Shadma Wahab
Development and Validation of Ultra Performance Liquid Chromatography (UPLC) Method for the Quantitative Estimation of Caffeine in Non-Alcoholic Soft and Energy Drinks
Journal of AOAC INTERNATIONAL 105(4), 1146, 2022
DOI: 10.1093/jaoacint/qsac016
[2]. Drita Abazi, Nora Limani-Bektashi, Olga Popovska
Development of thin-layer chromatographic method for determination of caffeine in black, green, and white tea
European Journal of Chemistry 12(3), 284, 2021
DOI: 10.5155/eurjchem.12.3.284-288.2131
[3]. Sherin F. Hammad, Samah F. El-Malla, Basma Z. El-Khateeb
Enhanced fluorimetric detection of diphenylpyraline HCl using micelle and cyclodextrin mediated approach: Spectrofluorimetric and micellar liquid chromatographic application for either single or combined formulation with caffeine and paracetamol
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 291, 122317, 2023
DOI: 10.1016/j.saa.2023.122317
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DOI Link: https://doi.org/10.5155/eurjchem.12.1.18-22.2036
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