

Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes
Mohammed Bahreldin Hussein (1)





(1) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(2) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(3) Department of Chemistry, Faculty of Education, Dalanj University, Dalanj, 53312 Sudan
(4) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(5) Department of Chemistry, Faculty of Education, West Kordofan University, El-Nuhud, 55511, Sudan
(*) Corresponding Author
Received: 15 Jan 2021 | Revised: 14 Feb 2021 | Accepted: 18 Feb 2021 | Published: 31 Mar 2021 | Issue Date: March 2021
Abstract
Schiff bases are versatile ligands, synthesized via condensation of primary amines with carbonyl compounds. In this study, equimolar amounts of 4-imidazolecarboxaldehyde and thiosemicarbazide were combined and the Schiff base 4-imidazolecarboxaldehyde thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes. For characterization purpose, infrared spectra, mass spectra, electronic spectra, thermal analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance spectra studies were carried out on the obtained complexes and ligand. The characterization data showed that the ligand acts as a bidentate coordinate to the metal ions through azomethine nitrogen and sulfur atoms. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus, Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram-negative) and one Fungi; Candida albicans, to assess their antimicrobial properties by disc diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.
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DOI: 10.5155/eurjchem.12.1.56-59.2070
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Department of Inorganic Chemistry, Technical University of Dresden, Germany.
Citations
[1]. Ilaria D’Agostino, Githa Elizabeth Mathew, Paola Angelini, Roberto Venanzoni, Giancarlo Angeles Flores, Andrea Angeli, Simone Carradori, Beatrice Marinacci, Luigi Menghini, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Bijo Mathew, Claudiu T. Supuran
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors
Journal of Enzyme Inhibition and Medicinal Chemistry 37(1), 986, 2022
DOI: 10.1080/14756366.2022.2055009

References
[1]. Quiroga, A. G.; Perez, J. M.; Lopez-Solera, I.; Masaguer, J. R.; Luque, A.; Roman, P.; Edwards, A.; Alonso, C.; Navarro-Ranninger, C. J. Med. Chem. 1998, 41 (9), 1399-1408.
https://doi.org/10.1021/jm970520d
[2]. Agarwal, R. K.; Singh, L.; Sharma, D. K. Bioinorg. Chem. Appl. 2006, 2006, 1-10.
[3]. Kovala-Demertzi, D.; Varadinova, T.; Genova, P.; Souza, P.; Demertzis, M. A. Bioinorg. Chem. Appl. 2007, 2007, 1-6.
https://doi.org/10.1155/2007/56165
[4]. Scovill, J. P.; Klayman, D. L.; Franchino, C. F. J. Med. Chem. 1982, 25 (10), 1261-1264.
https://doi.org/10.1021/jm00352a036
[5]. Costa, R. F. F.; Rebolledo, A. P.; Matencio, T.; Calado, H. D. R.; Ardisson, J. D.; Cortes, M. E.; Rodrigues, B. L.; Beraldo, H. J. Coord. Chem. 2005, 58 (15), 1307-1319.
https://doi.org/10.1080/00958970500213307
[6]. Pandey, O. P.; Sengupta, S. K.; Mishra, M. K.; Tripathi, C. M. Bioinorg. Chem. Appl. 2003, 1 (1), 35-44.
https://doi.org/10.1155/S1565363303000037
[7]. Kovala-Demertzi, D.; Boccarelli, A.; Demertzis, M. A.; Coluccia, M. Chemotherapy 2007, 53 (2), 148-152.
https://doi.org/10.1159/000099986
[8]. Shipman, C., Jr.; Smith, S. H.; Drach, J. C.; Klayman, D. L. Antiviral Res. 1986, 6 (4), 197-222.
https://doi.org/10.1016/0166-3542(86)90002-1
[9]. Lobana, T. S.; Casas, J. S.; Castineiras, A.; Garcia-Tasende, M. S.; Sanchez, A.; Sordo, J. Inorg. Chim. Acta 2003, 347, 23-32.
https://doi.org/10.1016/S0020-1693(02)01433-0
[10]. Hernandez, W.; Paz, J.; Vaisberg, A.; Spodine, E.; Richter, R.; Beyer, L. Bioinorg. Chem. Appl. 2008, 2008, 1-9.
https://doi.org/10.1155/2008/690952
[11]. Pingaew, R.; Prachayasittikul, S.; Ruchirawat, S. Molecules 2010, 15 (2), 988-996.
https://doi.org/10.3390/molecules15020988
[12]. Haraguchi, S. K.; Silva, A. A.; Vidotti, G. J.; Dos Santos, P. V.; Garcia, F. P.; Pedroso, R. B.; Nakamura, C. V.; De Oliveira, C. M. A.; Da Silva, C. C. Molecules 2011, 16 (2), 1166-1180.
https://doi.org/10.3390/molecules16021166
[13]. Deschamps, P.; Kulkarni, P. P.; Sarkar, B. Inorg. Chem. 2003, 42 (23), 7366-7368.
https://doi.org/10.1021/ic034760x
[14]. Sigel, H.; Saha, A.; Saha, N.; Carloni, P.; Kapinos, L. E.; Griesser, R. J. Inorg. Biochem. 2000, 78 (2), 129-137.
https://doi.org/10.1016/S0162-0134(99)00219-6
[15]. Russell, Hugo and Ayliffe's Principles and Practice of Disinfection, Preservation and Sterilization, Fraise, A. P., Maillard, J. Y., Sattar, S. A., Eds.; 5th Edition; Wiley-Blackwell, 2013.
[16]. West, D. X.; Lockwood, M. A.; Albert, J. N.; Liberta, A. E. Spectrochim. Acta A 1993, 49 (12), 1809-1816.
https://doi.org/10.1016/0584-8539(93)80250-E
[17]. Casas, J. S.; Castineiras, A.; Rodriguez-Argüelles, M. C.; Sanchez, A.; Sordo, J.; Vazquez-Lopez, A.; Vazquez-Lopez, E. M. J. Chem. Soc., Dalton Trans. 2000, 14, 2267-2272.
https://doi.org/10.1039/b002286l
[18]. Rodriguez-Arguelles, M. C.; Lopez-Silva, E. C.; Sanmartin, J.; Bacchi, A.; Pelizzi, C.; Zani, F. Inorg. Chim. Acta 2004, 357 (9), 2543-2552.
https://doi.org/10.1016/j.ica.2004.02.013
[19]. Houari, B.; Louhibi, S.; Boukli-Hacene, L.; Roisnel, T.; Taleb, M. Acta Cryst. E 2013, 69 (9), o1469-o1469.
https://doi.org/10.1107/S1600536813022927
[20]. Reis, D.; Despaigne, A.; Silva, J.; Silva, N.; Vilela, C.; Mendes, I.; Takahashi, J.; Beraldo, H. Molecules 2013, 18 (10), 12645-12662.
https://doi.org/10.3390/molecules181012645
[21]. Gobara, A. G. H., PhD Thesis, Synthesis, Characterization and Biological Activity of Some Thiosemicarbazone Ligands and their Complexes with Some M (II) ions, University of Gezira, 2017.
[22]. Tyagi, M.; Chandra, S. Open J. Inorg. Chem. 2012, 2 (3), 41-48.
https://doi.org/10.4236/ojic.2012.23007
[23]. Sapna, K.; Sharma, N. K.; Kohli, S. Orient. J. Chem. 2012, 28 (2), 969-974.
https://doi.org/10.13005/ojc/280244
[24]. Gujarathi, J. R.; Pawar, N. S.; Bendre. R. S. J. Chem. Pharm. Res. 2013, 5 (7), 161-168.
[25]. Mendes, I. C.; Moreira, J. P.; Speziali, N. L.; Mangrich, A. S.; Takahashi, J. A.; Beraldo, H. J. Braz. Chem. Soc. 2006, 17 (8), 1571-1577.
https://doi.org/10.1590/S0103-50532006000800013
[26]. Chandra, S.; Singh, G.; Tyagi, V. P.; Raizada, S. Synth. React. Inorg. Metal-Org. Chem. 2001, 31 (10), 1759-1769.
https://doi.org/10.1081/SIM-100108260
[27]. Al-Kubaisi, A. H. Bull. Korean Chem. Soc. 2004, 25 (1), 37-41
[28]. Bingol, H.; Coskun, A.; Akgemci, E. G.; Kaya, B.; Atalay, T. Chin. J. Chem. 2007, 25 (3), 307-311.
https://doi.org/10.1002/cjoc.200790060
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