European Journal of Chemistry 2021, 12(1), 56-59 | doi: https://doi.org/10.5155/eurjchem.12.1.56-59.2070 | Get rights and content

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Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes


Mohammed Bahreldin Hussein (1) orcid , Muna Mahdi Mohammed (2) orcid , Abdalla Gobara (3,*) orcid , Asha Fadllallah Wady (4) orcid , Awad Salim Ibrahim Holy (5) orcid

(1) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(2) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(3) Department of Chemistry, Faculty of Education, Dalanj University, Dalanj, 53312 Sudan
(4) Department of Chemistry, Faculty of Science, University of Kordofan, Elobeid, 52211, Sudan
(5) Department of Chemistry, Faculty of Education, West Kordofan University, El-Nuhud, 55511, Sudan
(*) Corresponding Author

Received: 15 Jan 2021 | Revised: 14 Feb 2021 | Accepted: 18 Feb 2021 | Published: 31 Mar 2021 | Issue Date: March 2021

Abstract


Schiff bases are versatile ligands, synthesized via condensation of primary amines with carbonyl compounds. In this study, equimolar amounts of 4-imidazolecarboxaldehyde and thiosemicarbazide were combined and the Schiff base 4-imidazolecarboxaldehyde thiosemicarbazone was prepared as a new bidentate complexing agent. The synthesized ligand was reacted with palladium (II) and platinum (II) ions yielding air-stable complexes. For characterization purpose, infrared spectra, mass spectra, electronic spectra, thermal analysis, proton nuclear magnetic resonance and 13-carbon nuclear magnetic resonance spectra studies were carried out on the obtained complexes and ligand. The characterization data showed that the ligand acts as a bidentate coordinate to the metal ions through azomethine nitrogen and sulfur atoms. An in vitro antimicrobial investigation was also carried out for the free ligand and its metal complexes against four bacteria; Bacillus cereus, Staphylococcus aureus (Gram-positive), Escherichia coli and Salmonella typhimurium (Gram-negative) and one Fungi; Candida albicans, to assess their antimicrobial properties by disc diffusion technique. Antimicrobial activity of the prepared complexes showed higher activity than the free ligand.


Keywords


Synthesis; Schiff base; Antimicrobial activity; Structural characterization; Pd(II) and Pt(II) complexes; Imidazole thiosemicarbazone

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DOI: 10.5155/eurjchem.12.1.56-59.2070

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Funding information


Department of Inorganic Chemistry, Technical University of Dresden, Germany.

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How to cite


Hussein, M.; Mohammed, M.; Gobara, A.; Wady, A.; Holy, A. Eur. J. Chem. 2021, 12(1), 56-59. doi:10.5155/eurjchem.12.1.56-59.2070
Hussein, M.; Mohammed, M.; Gobara, A.; Wady, A.; Holy, A. Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes. Eur. J. Chem. 2021, 12(1), 56-59. doi:10.5155/eurjchem.12.1.56-59.2070
Hussein, M., Mohammed, M., Gobara, A., Wady, A., & Holy, A. (2021). Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes. European Journal of Chemistry, 12(1), 56-59. doi:10.5155/eurjchem.12.1.56-59.2070
Hussein, Mohammed, Muna Mahdi Mohammed, Abdalla Gobara, Asha Fadllallah Wady, & Awad Salim Ibrahim Holy. "Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes." European Journal of Chemistry [Online], 12.1 (2021): 56-59. Web. 23 Sep. 2021
Hussein, Mohammed, Mohammed, Muna, Gobara, Abdalla, Wady, Asha, AND Holy, Awad. "Synthesis, characterization, and antimicrobial activity of 4-imidazolecarboxaldehyde thiosemicarbazone and its Pt(II) and Pd(II) complexes" European Journal of Chemistry [Online], Volume 12 Number 1 (31 March 2021)

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