European Journal of Chemistry 2021, 12(2), 222-234 | doi: https://doi.org/10.5155/eurjchem.12.2.222-234.2084 | Get rights and content

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The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges


Zeba Firdaus (1) orcid , Sushil Kumar Singh (2) orcid , Tryambak Deo Singh (3) orcid , Meenakshi Singh (4,*) orcid

(1) Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
(2) Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi, 221005, India
(3) Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
(4) Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India
(*) Corresponding Author

Received: 25 Jan 2021 | Revised: 22 Mar 2021 | Accepted: 28 Mar 2021 | Published: 30 Jun 2021 | Issue Date: June 2021

Abstract


The novel coronavirus, which emerged in China in late December 2019, is officially named as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The rapid spread of the virus across the continent has disrupted human life in every aspect leading to health and economic crises. The World Health Organization (WHO) declared the novel coronavirus outbreak as a global pandemic on March 11, 2020. In spite of complete lockdown and quarantine efforts in many countries, the occurrence of infections continues to rise, with more than 88 million laboratory-confirmed cases and over 1.9 million deaths worldwide as on January 10, 2021. Since the beginning of the outbreak, lot of intriguing studies about the phylogenetic evolution, epidemiology, pathogenesis, transmission, clinical characteristics, and possible treatment of Corona Virus Disease 2019 (COVID-19) have been published. This review aims to provide an insight into the progress in this regard and provides a reference for future studies including general awareness. We have discussed the origin, transmission, and infection mechanism of coronaviruses in host cells as well as available treatment options with relevant case studies. Furthermore, the stages of vaccine development, types of vaccines, and candidate vaccines with their phases of clinical trial are also incorporated. In a nutshell, the article is an attempt to retrieve the latest information available on virus behavior, efficacy of the available drugs, and development of candidate vaccines on SARS-CoV-2.


Keywords


COVID-19; SARS-CoV-2; Pathogenicity; Entry mechanism; Hydroxychloroquine; Vaccine development

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DOI: 10.5155/eurjchem.12.2.222-234.2084

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Council of Scientific and Industrial Research (CSIR), India.

References


[1]. Zhang, Q.; Wang, Y.; Qi, C.; Shen, L.; Li, J. J. Med. Virol. 2020, 92 (6), 540-545.
https://doi.org/10.1002/jmv.25733

[2]. Lai, C.-C.; Shih, T.-P.; Ko, W.-C.; Tang, H.-J.; Hsueh, P.-R. Int. J. Antimicrob. Agents 2020, 55 (3), 105924.
https://doi.org/10.1016/j.ijantimicag.2020.105924

[3]. Zhang, C.; Zheng, W.; Huang, X.; Bell, E. W.; Zhou, X.; Zhang, Y. J. Proteome Res. 2020, 19 (4), 1351-1360.
https://doi.org/10.1021/acs.jproteome.0c00129

[4]. Rohde, R., Novel Coronavirus (2019-nCoV) Update: Uncoating the Virus
https://asm.org/Articles/2020/January/2019-Novel-Coronavirus-2019-nCoV-Update-Uncoating (accessed December 9, 2020).

[5]. Yamamoto, N.; Bauer, G. Med. Hypotheses 2020, 144 (110160), 110160.
https://doi.org/10.1016/j.mehy.2020.110160

[6]. Toyoshima, Y.; Nemoto, K.; Matsumoto, S.; Nakamura, Y.; Kiyotani, K. J. Hum. Genet. 2020, 65 (12), 1075-1082.
https://doi.org/10.1038/s10038-020-0808-9

[7]. WHO Coronavirus (COVID-19) Dashboard
https://covid19.who.int/ (accessed December 9, 2020).

[8]. Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D. G. PLoS Med. 2009, 6 (7), e1000097.
https://doi.org/10.1371/journal.pmed.1000097

[9]. Chan, J. F.-W.; To, K. K.-W.; Tse, H.; Jin, D.-Y.; Yuen, K.-Y. Trends Microbiol. 2013, 21 (10), 544-555.
https://doi.org/10.1016/j.tim.2013.05.005

[10]. Wu, F.; Zhao, S.; Yu, B.; Chen, Y.-M.; Wang, W.; Song, Z.-G.; Hu, Y.; Tao, Z.-W.; Tian, J.-H.; Pei, Y.-Y.; Yuan, M.-L.; Zhang, Y.-L.; Dai, F.-H.; Liu, Y.; Wang, Q.-M.; Zheng, J.-J.; Xu, L.; Holmes, E. C.; Zhang, Y.-Z. Nature 2020, 579 (7798), 265-269.
https://doi.org/10.1038/s41586-020-2008-3

[11]. Wu, A.; Peng, Y.; Huang, B.; Ding, X.; Wang, X.; Niu, P.; Meng, J.; Zhu, Z.; Zhang, Z.; Wang, J.; Sheng, J.; Quan, L.; Xia, Z.; Tan, W.; Cheng, G.; Jiang, T. Cell Host Microbe 2020, 27 (3), 325-328.
https://doi.org/10.1016/j.chom.2020.02.001

[12]. Li, B.; Si, H.-R.; Zhu, Y.; Yang, X.-L.; Anderson, D. E.; Shi, Z.-L.; Wang, L.-F.; Zhou, P. D. mSphere 2020, 5 (1).
https://doi.org/10.1128/mSphere.00170-20

[13]. Rothan, H. A.; Byrareddy, S. N. J. Autoimmun. 2020, 109 (102433), 102433.
https://doi.org/10.1016/j.jaut.2020.102433

[14]. Wu, C.; Liu, Y.; Yang, Y.; Zhang, P.; Zhong, W.; Wang, Y.; Wang, Q.; Xu, Y.; Li, M.; Li, X.; Zheng, M.; Chen, L.; Li, H. Acta Pharm. Sin. B. 2020, 10 (5), 766-788.
https://doi.org/10.1016/j.apsb.2020.02.008

[15]. Chen, Y.; Liu, Q.; Guo, D. J. Med. Virol. 2020, 92 (4), 418-423.
https://doi.org/10.1002/jmv.25681

[16]. Marian, A. J. Cardiovasc. Pathol. 2021, 50 (107278), 107278.
https://doi.org/10.1016/j.carpath.2020.107278

[17]. Wan, Y.; Shang, J.; Graham, R.; Baric, R. S.; Li, F. J. Virol. 2020, 94 (7).
https://doi.org/10.1128/JVI.00127-20

[18]. Young, B. E.; Fong, S.-W.; Chan, Y.-H.; Mak, T.-M.; Ang, L. W.; Anderson, D. E.; Lee, C. Y.-P.; Amrun, S. N.; Lee, B.; Goh, Y. S.; Su, Y. C. F.; Wei, W. E.; Kalimuddin, S.; Chai, L. Y. A.; Pada, S.; Tan, S. Y.; Sun, L.; Parthasarathy, P.; Chen, Y. Y. C.; Barkham, T.; Lin, R. T. P.; Maurer-Stroh, S.; Leo, Y.-S.; Wang, L.-F.; Renia, L.; Lee, V. J.; Smith, G. J. D.; Lye, D. C.; Ng, L. F. P. Lancet 2020, 396 (10251), 603-611.
https://doi.org/10.1016/S0140-6736(20)31757-8

[19]. Mercatelli, D.; Giorgi, F. M. Front. Microbiol. 2020, 11.
https://doi.org/10.3389/fmicb.2020.01800

[20]. Dearlove, B.; Lewitus, E.; Bai, H.; Li, Y.; Reeves, D. B.; Joyce, M. G.; Scott, P. T.; Amare, M. F.; Vasan, S.; Michael, N. L.; Modjarrad, K.; Rolland, M. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (38), 23652-23662.
https://doi.org/10.1073/pnas.2008281117

[21]. Grubaugh, N. D.; Hanage, W. P.; Rasmussen, A. L. Cell 2020, 182 (4), 794-795.
https://doi.org/10.1016/j.cell.2020.06.040

[22]. Starr, T. N.; Greaney, A. J.; Hilton, S. K.; Ellis, D.; Crawford, K. H. D.; Dingens, A. S.; Navarro, M. J.; Bowen, J. E.; Tortorici, M. A.; Walls, A. C.; King, N. P.; Veesler, D.; Bloom, J. D. Cell 2020, 182 (5), 1295-1310.e20.
https://doi.org/10.1016/j.cell.2020.08.012

[23]. Rambaut, A.; Loman, N.; Pybus, O.; Barclay, W.; Barrett,J.; Carabelli,A.; Connor, T.; Peacock,T.; Robertson,D. L.; Volz, E. Preliminary genomic characterization of an emergent SARS-CoV-2 lineage in the UK defined by a novel set of spike mutations
https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 (accessed December 9, 2020).

[24]. Santos, J. C.; Passos, G. A. bioRxiv, 2021.
https://doi.org/10.1101/2020.12.29.424708

[25]. Hoffmann, M.; Kleine-Weber, H.; Krüger, N.; Müller, M.; Drosten, C.; Pöhlmann, S. bioRxiv, 2020.
https://doi.org/10.1101/2020.01.31.929042

[26]. Gralinski, L. E.; Menachery, V. D. Viruses 2020, 12 (2), 135.
https://doi.org/10.3390/v12020135

[27]. Xu, X.; Chen, P.; Wang, J.; Feng, J.; Zhou, H.; Li, X.; Zhong, W.; Hao, P. Sci. China Life Sci. 2020, 63 (3), 457-460.
https://doi.org/10.1007/s11427-020-1637-5

[28]. Raj, V. S.; Mou, H.; Smits, S. L.; Dekkers, D. H. W.; Müller, M. A.; Dijkman, R.; Muth, D.; Demmers, J. A. A.; Zaki, A.; Fouchier, R. A. M.; Thiel, V.; Drosten, C.; Rottier, P. J. M.; Osterhaus, A. D. M. E.; Bosch, B. J.; Haagmans, B. L. Nature 2013, 495 (7440), 251-254.
https://doi.org/10.1038/nature12005

[29]. Jaimes, J. A.; Millet, J. K.; Whittaker, G. R. iScience 2020, 23 (6), 101212.
https://doi.org/10.1016/j.isci.2020.101212

[30]. Lukassen, S.; Chua, R. L.; Trefzer, T.; Kahn, N. C.; Schneider, M. A.; Muley, T.; Winter, H.; Meister, M.; Veith, C.; Boots, A. W.; Hennig, B. P.; Kreuter, M.; Conrad, C.; Eils, R. EMBO J. 2020, 39 (10), e105114.
https://doi.org/10.15252/embj.20105114

[31]. Melenotte, C.; Silvin, A.; Goubet, A.-G.; Lahmar, I.; Dubuisson, A.; Zumla, A.; Raoult, D.; Merad, M.; Gachot, B.; Hénon, C.; Solary, E.; Fontenay, M.; André, F.; Maeurer, M.; Ippolito, G.; Piacentini, M.; Wang, F.-S.; Ginhoux, F.; Marabelle, A.; Kroemer, G.; Derosa, L.; Zitvogel, L. Oncoimmunology 2020, 9 (1), 1807836.
https://doi.org/10.1080/2162402X.2020.1807836

[32]. Mehta, P.; McAuley, D. F.; Brown, M.; Sanchez, E.; Tattersall, R. S.; Manson, J. J. Lancet 2020, 395 (10229), 1033-1034.
https://doi.org/10.1016/S0140-6736(20)30628-0

[33]. Akhmerov, A.; Marbán, E. Circ. Res. 2020, 126 (10), 1443-1455.
https://doi.org/10.1161/CIRCRESAHA.120.317055

[34]. Martín-Rojas, R. M.; Pérez-Rus, G.; Delgado-Pinos, V. E.; Domingo-González, A.; Regalado-Artamendi, I.; Alba-Urdiales, N.; Demelo-Rodríguez, P.; Monsalvo, S.; Rodríguez-Macías, G.; Ballesteros, M.; Osorio-Prendes, S.; Díez-Martín, J. L.; Pascual Izquierdo, C. Eur. J. Haematol. 2020, 105 (6), 741-750.
https://doi.org/10.1111/ejh.13501

[35]. Reddy, S. T.; Garg, T.; Shah, C.; Nascimento, F. A.; Imran, R.; Kan, P.; Bowry, R.; Gonzales, N.; Barreto, A.; Kumar, A.; Volpi, J.; Misra, V.; Chiu, D.; Gadhia, R.; Savitz, S. I. Case Rep. Neurol. 2020, 12 (2), 199-209.
https://doi.org/10.1159/000508958

[36]. Baig, A. M.; Khaleeq, A.; Ali, U.; Syeda, H. ACS Chem. Neurosci. 2020, 11 (7), 995-998.
https://doi.org/10.1021/acschemneuro.0c00122

[37]. Bittmann, S.; Weissenstein, A.; Villalon, G.; Moschuring-Alieva, E.; Luchter, E. J. Clin. Med. Res. 2020, 12 (5), 320-322.
https://doi.org/10.14740/jocmr4161

[38]. Solomon, I. H.; Normandin, E.; Bhattacharyya, S.; Mukerji, S. S.; Keller, K.; Ali, A. S.; Adams, G.; Hornick, J. L.; Padera, R. F., Jr; Sabeti, P. N. Engl. J. Med. 2020, 383 (10), 989-992.
https://doi.org/10.1056/NEJMc2019373

[39]. Mao, L.; Jin, H.; Wang, M.; Hu, Y.; Chen, S.; He, Q.; Chang, J.; Hong, C.; Zhou, Y.; Wang, D.; Miao, X.; Li, Y.; Hu, B. JAMA Neurol. 2020, 77 (6), 683-690.
https://doi.org/10.1001/jamaneurol.2020.1127

[40]. Poland, G. A.; Ovsyannikova, I. G.; Kennedy, R. B. Lancet 2020, 396 (10262), 1595-1606.
https://doi.org/10.1016/S0140-6736(20)32137-1

[41]. Stephens, D. S.; McElrath, M. J. JAMA 2020, 324 (13), 1279-1281.
https://doi.org/10.1001/jama.2020.16656

[42]. Zeng, H.; Xu, C.; Fan, J.; Tang, Y.; Deng, Q.; Zhang, W.; Long, X. JAMA 2020, 323 (18), 1848-1849.

[43]. Addetia, A.; Crawford, K. H. D.; Dingens, A.; Zhu, H.; Roychoudhury, P.; Huang, M.-L.; Jerome, K. R.; Bloom, J. D.; Greninger, A. L. J. Clin. Microbiol. 2020, 58 (11).
https://doi.org/10.1128/JCM.02107-20

[44]. Iwasaki, A. Lancet Infect. Dis. 2021, 21 (1), 3-5.

[45]. Organization, W. H. Coronavirus Disease 2019 (COVID-19) Situation Report-51; World Health Organization: Geneva, Switzerland, 2020.

[46]. Qu, G.; Li, X.; Hu, L.; Jiang, G. Environ. Sci. Technol. 2020, 54 (7), 3730-3732.
https://doi.org/10.1021/acs.est.0c01102

[47]. Weber, D. J.; Rutala, W. A.; Fischer, W. A.; Kanamori, H.; Sickbert-Bennett, E. E. Am. J. Infect. Control 2016, 44 (5), e91-e100.
https://doi.org/10.1016/j.ajic.2015.11.018

[48]. Wang, W.; Xu, Y.; Gao, R.; Lu, R.; Han, K.; Wu, G.; Tan, W. JAMA 2020, 323 (18), 1843-1844.

[49]. Peiris, J. S. M.; Chu, C. M.; Cheng, V. C. C.; Chan, K. S.; Hung, I. F. N.; Poon, L. L. M.; Law, K. I.; Tang, B. S. F.; Hon, T. Y. W.; Chan, C. S.; Chan, K. H.; Ng, J. S. C.; Zheng, B. J.; Ng, W. L.; Lai, R. W. M.; Guan, Y.; Yuen, K. Y. Lancet 2003, 361 (9371), 1767-1772.
https://doi.org/10.1016/S0140-6736(03)13412-5

[50]. Casanova, L.; Rutala, W. A.; Weber, D. J.; Sobsey, M. D. Water Res. 2009, 43 (7), 1893-1898.
https://doi.org/10.1016/j.watres.2009.02.002

[51]. Yu, I. T. S.; Li, Y.; Wong, T. W.; Tam, W.; Chan, A. T.; Lee, J. H. W.; Leung, D. Y. C.; Ho, T. N. Engl. J. Med. 2004, 350 (17), 1731-1739.
https://doi.org/10.1056/NEJMoa032867

[52]. Huang, C.; Wang, Y.; Li, X.; Ren, L.; Zhao, J.; Hu, Y.; Zhang, L.; Fan, G.; Xu, J.; Gu, X.; Cheng, Z.; Yu, T.; Xia, J.; Wei, Y.; Wu, W.; Xie, X.; Yin, W.; Li, H.; Liu, M.; Xiao, Y.; Gao, H.; Guo, L.; Xie, J.; Wang, G.; Jiang, R.; Gao, Z.; Jin, Q.; Wang, J.; Cao, B. Lancet 2020, 395 (10223), 497-506.
https://doi.org/10.1016/S0140-6736(20)30183-5

[53]. Wu, Z.; McGoogan, J. M. JAMA 2020, 323 (13), 1239-1242.
https://doi.org/10.1001/jama.2020.2648

[54]. Bhopal, S. S.; Bhopal, R. Lancet 2020, 396 (10250), 532-533.
https://doi.org/10.1016/S0140-6736(20)31748-7

[55]. Chen, H.; Guo, J.; Wang, C.; Luo, F.; Yu, X.; Zhang, W.; Li, J.; Zhao, D.; Xu, D.; Gong, Q.; Liao, J.; Yang, H.; Hou, W.; Zhang, Y. Lancet 2020, 395 (10226), 809-815.
https://doi.org/10.1016/S0140-6736(20)30360-3

[56]. Walker, K. F.; O'Donoghue, K.; Grace, N.; Dorling, J.; Comeau, J. L.; Li, W.; Thornton, J. G. BJOG 2020, 127 (11), 1324-1336.
https://doi.org/10.1111/1471-0528.16362

[57]. Trevisanuto, D.; Cavallin, F.; Cavicchiolo, M. E.; Borellini, M.; Calgaro, S.; Baraldi, E. Arch. Dis. Child. Fetal Neonatal Ed. 2020, fetalneonatal-2020-319837.

[58]. Stokes, E. K.; Zambrano, L. D.; Anderson, K. N.; Marder, E. P.; Raz, K. M.; El Burai Felix, S.; Tie, Y.; Fullerton, K. E. MMWR Morb. Mortal. Wkly. Rep. 2020, 69 (24), 759-765.
https://doi.org/10.15585/mmwr.mm6924e2

[59]. Heald-Sargent, T.; Muller, W. J.; Zheng, X.; Rippe, J.; Patel, A. B.; Kociolek, L. K. JAMA Pediatr. 2020, 174 (9), 902-903.
https://doi.org/10.1001/jamapediatrics.2020.3651

[60]. Zimmer, C.; Corum, J.; Wee, S.-L. Coronavirus Vaccine Tracker. The New York times. The New York Times April 1, 2021.
https://www.nytimes.com/interactive/2020/science/coronavirus-vaccine-tracker.html (accessed April 1, 2021).

[61]. Elfiky, A. A. Life Sci. 2020, 248 (117477), 117477.
https://doi.org/10.1016/j.lfs.2020.117477

[62]. Li, G.; De Clercq, E. Nat. Rev. Drug Discov. 2020, 19 (3), 149-150.
https://doi.org/10.1038/d41573-020-00016-0

[63]. Radhakrishnan, A.; Arunachalam, R.; Elango, A. SSRN Electron. J. 2020.
https://doi.org/10.2139/ssrn.3636958

[64]. Agrawal, U.; Raju, R.; Udwadia, Z. F. Med J. Armed Forces India 2020, 76 (4), 370-376.
https://doi.org/10.1016/j.mjafi.2020.08.004

[65]. Cai, Q.; Yang, M.; Liu, D.; Chen, J.; Shu, D.; Xia, J.; Liao, X.; Gu, Y.; Cai, Q.; Yang, Y.; Shen, C.; Li, X.; Peng, L.; Huang, D.; Zhang, J.; Zhang, S.; Wang, F.; Liu, J.; Chen, L.; Chen, S.; Wang, Z.; Zhang, Z.; Cao, R.; Zhong, W.; Liu, Y.; Liu, L. Engineering (Beijing) 2020, 6 (10), 1192-1198.
https://doi.org/10.1016/j.eng.2020.03.007

[66]. Li H.; Wang Y. M.; Xu J. Y.; Cao B. Zhonghua Jie He He Hu Xi Za Zhi 2020, 43 (0), E002.

[67]. Holshue, M. L.; DeBolt, C.; Lindquist, S.; Lofy, K. H.; Wiesman, J.; Bruce, H.; Spitters, C.; Ericson, K.; Wilkerson, S.; Tural, A.; Diaz, G.; Cohn, A.; Fox, L.; Patel, A.; Gerber, S. I.; Kim, L.; Tong, S.; Lu, X.; Lindstrom, S.; Pallansch, M. A.; Weldon, W. C.; Biggs, H. M.; Uyeki, T. M.; Pillai, S. K. N. Engl. J. Med. 2020, 382 (10), 929-936.
https://doi.org/10.1056/NEJMoa2001191

[68]. Beigel, J. H.; Tomashek, K. M.; Dodd, L. E.; Mehta, A. K.; Zingman, B. S.; Kalil, A. C.; Hohmann, E.; Chu, H. Y.; Luetkemeyer, A.; Kline, S.; Lopez de Castilla, D.; Finberg, R. W.; Dierberg, K.; Tapson, V.; Hsieh, L.; Patterson, T. F.; Paredes, R.; Sweeney, D. A.; Short, W. R.; Touloumi, G.; Lye, D. C.; Ohmagari, N.; Oh, M.-D.; Ruiz-Palacios, G. M.; Benfield, T.; Fätkenheuer, G.; Kortepeter, M. G.; Atmar, R. L.; Creech, C. B.; Lundgren, J.; Babiker, A. G.; Pett, S.; Neaton, J. D.; Burgess, T. H.; Bonnett, T.; Green, M.; Makowski, M.; Osinusi, A.; Nayak, S.; Lane, H. C. N. Engl. J. Med. 2020, 383 (19), 1813-1826.
https://doi.org/10.1056/NEJMoa2007764

[69]. Case Medical Research. Case Medical Research 2020.
https://doi.org/10.31525/ct1-nct04292730 (accessed December 9, 2020).

[70]. Cao, B.; Wang, Y.; Wen, D.; Liu, W.; Wang, J.; Fan, G.; Ruan, L.; Song, B.; Cai, Y.; Wei, M.; Li, X.; Xia, J.; Chen, N.; Xiang, J.; Yu, T.; Bai, T.; Xie, X.; Zhang, L.; Li, C.; Yuan, Y.; Chen, H.; Li, H.; Huang, H.; Tu, S.; Gong, F.; Liu, Y.; Wei, Y.; Dong, C.; Zhou, F.; Gu, X.; Xu, J.; Liu, Z.; Zhang, Y.; Li, H.; Shang, L.; Wang, K.; Li, K.; Zhou, X.; Dong, X.; Qu, Z.; Lu, S.; Hu, X.; Ruan, S.; Luo, S.; Wu, J.; Peng, L.; Cheng, F.; Pan, L.; Zou, J.; Jia, C.; Wang, J.; Liu, X.; Wang, S.; Wu, X.; Ge, Q.; He, J.; Zhan, H.; Qiu, F.; Guo, L.; Huang, C.; Jaki, T.; Hayden, F. G.; Horby, P. W.; Zhang, D.; Wang, C. N. Engl. J. Med. 2020, 382 (19), 1787-1799.
https://doi.org/10.1056/NEJMoa2001282

[71]. Hung, I. F.-N.; Lung, K.-C.; Tso, E. Y.-K.; Liu, R.; Chung, T. W.-H.; Chu, M.-Y.; Ng, Y.-Y.; Lo, J.; Chan, J.; Tam, A. R.; Shum, H.-P.; Chan, V.; Wu, A. K.-L.; Sin, K.-M.; Leung, W.-S.; Law, W.-L.; Lung, D. C.; Sin, S.; Yeung, P.; Yip, C. C.-Y.; Zhang, R. R.; Fung, A. Y.-F.; Yan, E. Y.-W.; Leung, K.-H.; Ip, J. D.; Chu, A. W.-H.; Chan, W.-M.; Ng, A. C.-K.; Lee, R.; Fung, K.; Yeung, A.; Wu, T.-C.; Chan, J. W.-M.; Yan, W.-W.; Chan, W.-M.; Chan, J. F.-W.; Lie, A. K.-W.; Tsang, O. T.-Y.; Cheng, V. C.-C.; Que, T.-L.; Lau, C.-S.; Chan, K.-H.; To, K. K.-W.; Yuen, K.-Y. Lancet 2020, 395 (10238), 1695-1704.
https://doi.org/10.1016/S0140-6736(20)31042-4

[72]. Lopinavir/Ritonavir for the Treatment of COVID-19 Positive Patients With Cancer and Immune Suppression in the Last Year
https://clinicaltrials.gov/ct2/show/NCT04455958 (accessed December 9, 2020).

[73]. Dong, L.; Hu, S.; Gao, J. Drug Discov. Ther. 2020, 14 (1), 58-60.
https://doi.org/10.5582/ddt.2020.01012

[74]. Lee, J. S.; Shin, E.-C. Nat. Rev. Immunol. 2020, 20 (10), 585-586.
https://doi.org/10.1038/s41577-020-00429-3

[75]. Zhou, Q.; Chen, V.; Shannon, C. P.; Wei, X.-S.; Xiang, X.; Wang, X.; Wang, Z.-H.; Tebbutt, S. J.; Kollmann, T. R.; Fish, E. N. Front. Immunol. 2020, 11, 1061.

[76]. Colson, P.; Rolain, J.-M.; Lagier, J.-C.; Brouqui, P.; Raoult, D. Int. J. Antimicrob. Agents 2020, 55 (4), 105932.
https://doi.org/10.1016/j.ijantimicag.2020.105932

[77]. Jie, Z.; He, H.; Xi, H.; Zhi, Z. Zhonghua Jie He He Hu Xi Za Zhi 2020, 43 (3), 185-188.

[78]. Gao, J.; Tian, Z.; Yang, X. Biosci. Trends 2020, 14 (1), 72-73.
https://doi.org/10.5582/bst.2020.01047

[79]. Gautret, P.; Lagier, J.-C.; Parola, P.; Hoang, V. T.; Meddeb, L.; Sevestre, J.; Mailhe, M.; Doudier, B.; Aubry, C.; Amrane, S.; Seng, P.; Hocquart, M.; Eldin, C.; Finance, J.; Vieira, V. E.; Tissot-Dupont, H. T.; Honoré, S.; Stein, A.; Million, M.; Colson, P.; La Scola, B.; Veit, V.; Jacquier, A.; Deharo, J.-C.; Drancourt, M.; Fournier, P. E.; Rolain, J.-M.; Brouqui, P.; Raoult, D. Travel Med. Infect. Dis. 2020, 34 (101663), 101663.
https://doi.org/10.1016/j.tmaid.2020.101663

[80]. "Solidarity" clinical trial for COVID-19 treatments
https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments (accessed December 9, 2020).

[81]. Randomised Evaluation of COVID-19 Therapy - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/ (accessed December 9, 2020).

[82]. Mehra, M. R.; Ruschitzka, F.; Patel, A. N. Lancet 2020, 395 (10240), 1820.
https://doi.org/10.1016/S0140-6736(20)31324-6

[83]. Torjesen, I. BMJ 2020, 369, m2263.
https://doi.org/10.1136/bmj.m2263

[84]. Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons With COVID-19
https://clinicaltrials.gov/ct2/show/NCT04358068 (accessed December 9, 2020).

[85]. Waldrop, T.; Alsup, D.; McLaughlin, E. C. Here's What You Need to Know about Chloroquine. CNN. March 24, 2020.
https://edition.cnn.com/2020/03/23/health/arizona-coronavirus-chloroquine-death/index.html (accessed December 9, 2020).

[86]. Consortium. Lancet 2012, 379 (9822), 1214-1224.
https://doi.org/10.1016/S0140-6736(12)60110-X

[87]. Roche provides an update on the phase III COVACTA trial of Actemra/RoActemra in hospitalised patients with severe COVID-19 associated pneumonia
https://www.roche.com/investors/updates/inv-update-2020-07-29.htm (accessed December 9, 2020).

[88]. Cortegiani, A.; Ippolito, M.; Greco, M.; Granone, V.; Protti, A.; Gregoretti, C.; Giarratano, A.; Einav, S.; Cecconi, M. Pulmonology 2021, 27 (1), 52-66.
https://doi.org/10.1016/j.pulmoe.2020.07.003

[89]. Organization, W. H. Clinical Management of COVID-19: Interim Guidance. World Health Organization 2020.

[90]. Chen, L.; Xiong, J.; Bao, L.; Shi, Y. Convalescent Plasma as a Potential Therapy for COVID-19. Lancet Infect. Dis. 2020, 20 (4), 398-400.
https://doi.org/10.1016/S1473-3099(20)30141-9

[91]. Joyner, M. J.; Bruno, K. A.; Klassen, S. A.; Kunze, K. L.; Johnson, P. W.; Lesser, E. R.; Wiggins, C. C.; Senefeld, J. W.; Klompas, A. M.; Hodge, D. O.; Shepherd, J. R. A.; Rea, R. F.; Whelan, E. R.; Clayburn, A. J.; Spiegel, M. R.; Baker, S. E.; Larson, K. F.; Ripoll, J. G.; Andersen, K. J.; Buras, M. R.; Vogt, M. N. P.; Herasevich, V.; Dennis, J. J.; Regimbal, R. J.; Bauer, P. R.; Blair, J. E.; van Buskirk, C. M.; Winters, J. L.; Stubbs, J. R.; van Helmond, N.; Butterfield, B. P.; Sexton, M. A.; Diaz Soto, J. C.; Paneth, N. S.; Verdun, N. C.; Marks, P.; Casadevall, A.; Fairweather, D.; Carter, R. E.; Wright, R. S. Mayo Clin. Proc. 2020, 95 (9), 1888-1897.
https://doi.org/10.1016/j.mayocp.2020.06.028

[92]. Xia, X.; Li, K.; Wu, L.; Wang, Z.; Zhu, M.; Huang, B.; Li, J.; Wang, Z.; Wu, W.; Wu, M.; Li, W.; Li, L.; Cai, Y.; Bosco, B.; Zhong, A.; Liu, X.; Lv, T.; Gan, Z.; Chen, G.; Pan, Y.; Liu, C.; Zhang, K.; Xu, X.; Wang, C.; Wang, Q. Blood 2020, 136 (6), 755-759.
https://doi.org/10.1182/blood.2020007079

[93]. Remy, V.; Largeron, N.; Quilici, S.; Carroll, S. Value Health 2014, 17 (7), A450.
https://doi.org/10.1016/j.jval.2014.08.1211

[94]. Neher, R. A.; Dyrdak, R.; Druelle, V.; Hodcroft, E. B.; Albert, J. Swiss Med. Wkly 2020, 150, w20224.

[95]. Zhang, J.; Zeng, H.; Gu, J.; Li, H.; Zheng, L.; Zou, Q. Vaccines (Basel) 2020, 8 (2), 153.
https://doi.org/10.3390/vaccines8020153

[96]. Singh, D.; Yi, S. V. Exp. Mol. Med. 2021.
https://doi.org/10.1038/s12276-021-00604-z

[97]. Sharma, A.; Krause, A.; Worgall, S. Hum. Vaccin. 2011, 7 (10), 999-1011.
https://doi.org/10.4161/hv.7.10.16369

[98]. Pardi, N.; Hogan, M. J.; Porter, F. W.; Weissman, D. Nat. Rev. Drug Discov. 2018, 17 (4), 261-279.
https://doi.org/10.1038/nrd.2017.243

[99]. Jahanafrooz, Z.; Baradaran, B.; Mosafer, J.; Hashemzaei, M.; Rezaei, T.; Mokhtarzadeh, A.; Hamblin, M. R. Drug Discov. Today 2020, 25 (3), 552-560.
https://doi.org/10.1016/j.drudis.2019.12.003

[100]. Adnal, M. Pfizer concludes phase 3 study of COVID-19 vaccine candidate, says it's 95% effective
https://www.oneindia.com/international/pfizer-concludes-phase-3-study-of-covid-19-vaccine-candidate-says-it-s-95-effective-3178319.html (accessed December 9, 2020).

[101]. Herper, M.; Branswell, H.; McFarling, U. L.; Florko, N.; St. Fleur, N. Moderna's Covid-19 vaccine is strongly effective, early look at data show
https://www.statnews.com/2020/11/16/modernas-covid-19-vaccine-is-strongly-effective-early-look-at-data-show/ (accessed December 9, 2020).

[102]. Burton, T. M.; Hopkins, J. S. FDA Set to Release Analyses of the Pfizer-BioNTech Covid-19 Vaccine. Wall Street journal (Eastern ed.). wsj.com December 8, 2020.
https://www.wsj.com/articles/fda-set-to-release-analyses-of-the-pfizer-biontech-covid-19-vaccine-11607423403 (accessed December 9, 2020).

[103]. Triggle, J. G. A. Covid-19: Oxford-AstraZeneca Vaccine Approved for Use in UK. BBC. December 30, 2020.
https://www.bbc.com/news/health-55280671 (accessed December 9, 2020).

[104]. Liu, M. A. Vaccines (Basel) 2019, 7 (2), 37.
https://doi.org/10.3390/vaccines7020037

[105]. Azmi, F.; Ahmad Fuaad, A. A. H.; Skwarczynski, M.; Toth, I. Hum. Vaccin. Immunother. 2014, 10 (3), 778-796.
https://doi.org/10.4161/hv.27332

[106]. Hassan, A. O.; Kafai, N. M.; Dmitriev, I. P.; Fox, J. M.; Smith, B. K.; Harvey, I. B.; Chen, R. E.; Winkler, E. S.; Wessel, A. W.; Case, J. B.; Kashentseva, E.; McCune, B. T.; Bailey, A. L.; Zhao, H.; VanBlargan, L. A.; Dai, Y.-N.; Ma, M.; Adams, L. J.; Shrihari, S.; Danis, J. E.; Gralinski, L. E.; Hou, Y. J.; Schäfer, A.; Kim, A. S.; Keeler, S. P.; Weiskopf, D.; Baric, R. S.; Holtzman, M. J.; Fremont, D. H.; Curiel, D. T.; Diamond, M. S. Cell 2020, 183 (1), 169-184.e13.

[107]. Feng, L.; Wang, Q.; Shan, C.; Yang, C.; Feng, Y.; Wu, J.; Liu, X.; Zhou, Y.; Jiang, R.; Hu, P.; Liu, X.; Zhang, F.; Li, P.; Niu, X.; Liu, Y.; Zheng, X.; Luo, J.; Sun, J.; Gu, Y.; Liu, B.; Xu, Y.; Li, C.; Pan, W.; Zhao, J.; Ke, C.; Chen, X.; Xu, T.; Zhong, N.; Guan, S.; Yuan, Z.; Chen, L. Nat. Commun. 2020, 11 (1), 4207.
https://doi.org/10.1038/s41467-020-18077-5

[108]. Prasad, A.; Muthamilarasan, M.; Prasad, M. Plant Cell Rep. 2020, 39 (9), 1109-1114.
https://doi.org/10.1007/s00299-020-02560-w

[109]. Silverman, E. Medicago strikes Covid-19 vaccine deals with GSK, Dynavax
https://www.statnews.com/pharmalot/2020/07/09/covid19-coronavirus-pandemic-vaccines-medicago-glaxo-dynavax/ (accessed December 9, 2020).

[110]. Rajapaksha, H.; Perera, B. T.; Meepage, J.; Perera, R. T.; Dissanayake, C. Eur. J. Chem. 2020, 11 (4), 351-363.
https://doi.org/10.5155/eurjchem.11.4.351-363.2043

[111]. Chen, C.; Zhang, Y.; Huang, J.; Yin, P.; Cheng, Z.; Wu, J.; Chen, S.; Zhang, Y.; Chen, B.; Lu, M.; Luo, Y.; Ju, L.; Zhang, J.; Wang, X. bioRxiv, 2020.
https://doi.org/10.1101/2020.03.17.20037432

[112]. Wang, Y.; Zhang, D.; Du, G.; Du, R.; Zhao, J.; Jin, Y.; Fu, S.; Gao, L.; Cheng, Z.; Lu, Q.; Hu, Y.; Luo, G.; Wang, K.; Lu, Y.; Li, H.; Wang, S.; Ruan, S.; Yang, C.; Mei, C.; Wang, Y.; Ding, D.; Wu, F.; Tang, X.; Ye, X.; Ye, Y.; Liu, B.; Yang, J.; Yin, W.; Wang, A.; Fan, G.; Zhou, F.; Liu, Z.; Gu, X.; Xu, J.; Shang, L.; Zhang, Y.; Cao, L.; Guo, T.; Wan, Y.; Qin, H.; Jiang, Y.; Jaki, T.; Hayden, F. G.; Horby, P. W.; Cao, B.; Wang, C. Lancet 2020, 395 (10236), 1569-1578.
https://doi.org/10.1016/S0140-6736(20)31022-9

[113]. Gautret, P.; Lagier, J.-C.; Parola, P.; Hoang, V. T.; Meddeb, L.; Mailhe, M.; Doudier, B.; Courjon, J.; Giordanengo, V.; Vieira, V. E.; Tissot Dupont, H.; Honoré, S.; Colson, P.; Chabrière, E.; La Scola, B.; Rolain, J.-M.; Brouqui, P.; Raoult, D. Int. J. Antimicrob. Agents 2020, 56 (1), 105949.
https://doi.org/10.1016/j.ijantimicag.2020.105949

[114]. Guaraldi, G.; Meschiari, M.; Cozzi-Lepri, A.; Milic, J.; Tonelli, R.; Menozzi, M.; Franceschini, E.; Cuomo, G.; Orlando, G.; Borghi, V.; Santoro, A.; Di Gaetano, M.; Puzzolante, C.; Carli, F.; Bedini, A.; Corradi, L.; Fantini, R.; Castaniere, I.; Tabbì, L.; Girardis, M.; Tedeschi, S.; Giannella, M.; Bartoletti, M.; Pascale, R.; Dolci, G.; Brugioni, L.; Pietrangelo, A.; Cossarizza, A.; Pea, F.; Clini, E.; Salvarani, C.; Massari, M.; Viale, P. L.; Mussini, C. Lancet Rheumatol 2020, 2 (8), e474-e484.
https://doi.org/10.1016/S2665-9913(20)30173-9

[115]. Liu, S. T. H.; Lin, H.-M.; Baine, I.; Wajnberg, A.; Gumprecht, J. P.; Rahman, F.; Rodriguez, D.; Tandon, P.; Bassily-Marcus, A.; Bander, J.; Sanky, C.; Dupper, A.; Zheng, A.; Nguyen, F. T.; Amanat, F.; Stadlbauer, D.; Altman, D. R.; Chen, B. K.; Krammer, F.; Mendu, D. R.; Firpo-Betancourt, A.; Levin, M. A.; Bagiella, E.; Casadevall, A.; Cordon-Cardo, C.; Jhang, J. S.; Arinsburg, S. A.; Reich, D. L.; Aberg, J. A.; Bouvier, N. M. Nat. Med. 2020, 26 (11), 1708-1713.
https://doi.org/10.1038/s41591-020-1088-9

[116]. Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152) for COVID-19 in Healthy Volunteers - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04471519 (accessed December 9, 2020).

[117]. Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04456595 (accessed December 9, 2020).

[118]. A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04510207 (accessed December 9, 2020).

[119]. Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults
https://clinicaltrials.gov/ct2/show/NCT04516746 (accessed December 9, 2020).

[120]. Phase III Trial of A COVID-19 Vaccine of Adenovirus Vector in Adults 18 Years Old and Above
https://clinicaltrials.gov/ct2/show/NCT04526990 (accessed December 9, 2020).

[121]. A Study of Ad26.COV2.S in Adults (COVID-19)
https://clinicaltrials.gov/ct2/show/NCT04436276 (accessed December 9, 2020).

[122]. Clinical Trial to Evaluate the Safety and Immunogenicity of the COVID-19 Vaccine - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04497298 (accessed December 9, 2020).

[123]. Clinical Trial of Efficacy, Safety, and Immunogenicity of Gam-COVID-Vac Vaccine Against COVID-19 - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04530396 (accessed December 9, 2020).

[124]. A Study to Evaluate the Safety, Reactogenicity, and Effectiveness of mRNA-1273 Vaccine in Adolescents 12 to <18 Years Old to Prevent COVID-19 - Full Text View - ClinicalTrials.Gov
https://clinicaltrials.gov/ct2/show/NCT04649151 (accessed December 9, 2020).

[125]. Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals
https://www.clinicaltrials.gov/ct2/show/NCT04368728 (accessed December 9, 2020).

[126]. A Dose-Confirmation Study to Evaluate the Safety, Reactogenicity and Immunogenicity of Vaccine CVnCoV in Healthy Adults for COVID-19
https://clinicaltrials.gov/ct2/show/NCT04515147 (accessed December 9, 2020).

[127]. Ascending Dose Study of Investigational SARS-CoV-2 Vaccine ARCT-021 in Healthy Adult Subjects
https://clinicaltrials.gov/ct2/show/NCT04480957 (accessed December 9, 2020).

[128]. Ward, D.; McCormack, S. Clinical Trial to Assess the Safety of a Coronavirus Vaccine in Healthy Men and Women 2020.
https://doi.org/10.1186/ISRCTN17072692

[129]. CTRI
http://ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45306&EncHid=&userName=vaccine (accessed December 9, 2020).

[130]. Safety and Immunogenicity Study of GX-19, a COVID-19 Preventive DNA Vaccine in Healthy Adults
https://clinicaltrials.gov/ct2/show/NCT04445389 (accessed December 9, 2020).

[131]. Safety, Tolerability and Immunogenicity of INO-4800 Followed by Electroporation in Healthy Volunteers for COVID19
https://clinicaltrials.gov/ct2/show/NCT04447781 (accessed December 9, 2020).

[132]. Study of COVID-19 DNA Vaccine (AG0301-COVID19)
https://clinicaltrials.gov/ct2/show/NCT04463472 (accessed December 9, 2020).

[133]. Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS Nanoparticle Vaccine With/Without Matrix-M Adjuvant
https://clinicaltrials.gov/ct2/show/NCT04368988 (accessed December 9, 2020).

[134]. KBP-201 COVID-19 Vaccine Trial in Healthy Volunteers
https://clinicaltrials.gov/ct2/show/NCT04473690 (accessed December 9, 2020).

[135]. A Phase III Clinical Trial to Determine the Safety and Efficacy of ZF2001 for Prevention of COVID-19
https://clinicaltrials.gov/ct2/show/NCT04646590 (accessed December 9, 2020).

[136]. Monovalent Recombinant COVID19 Vaccine - Full Text View - ClinicalTrials.gov
https://clinicaltrials.gov/ct2/show/NCT04453852 (accessed December 9, 2020).

[137]. Study of a Recombinant Coronavirus-Like Particle COVID-19 Vaccine in Adults
https://clinicaltrials.gov/ct2/show/NCT04636697 (accessed December 9, 2020).


How to cite


Firdaus, Z.; Singh, S.; Singh, T.; Singh, M. Eur. J. Chem. 2021, 12(2), 222-234. doi:10.5155/eurjchem.12.2.222-234.2084
Firdaus, Z.; Singh, S.; Singh, T.; Singh, M. The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges. Eur. J. Chem. 2021, 12(2), 222-234. doi:10.5155/eurjchem.12.2.222-234.2084
Firdaus, Z., Singh, S., Singh, T., & Singh, M. (2021). The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges. European Journal of Chemistry, 12(2), 222-234. doi:10.5155/eurjchem.12.2.222-234.2084
Firdaus, Zeba, Sushil Kumar Singh, Tryambak Deo Singh, & Meenakshi Singh. "The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges." European Journal of Chemistry [Online], 12.2 (2021): 222-234. Web. 25 Jul. 2021
Firdaus, Zeba, Singh, Sushil, Singh, Tryambak, AND Singh, Meenakshi. "The scientific community in COVID-19 global pandemic: A systematic update on recent progress and challenges" European Journal of Chemistry [Online], Volume 12 Number 2 (30 June 2021)

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