European Journal of Chemistry 2021, 12(3), 235-241 | doi: https://doi.org/10.5155/eurjchem.12.3.235-241.2106 | Get rights and content

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Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies


Pedro Henrique do Nascimento Pereira (1) orcid , Jackelinne Camargo Lima (2) orcid , Victor Marcelo Deflon (3) orcid , Geoffroy Roger Pointer Malpass (4) orcid , Ronaldo Junio de Oliveira (5) orcid , Pedro Ivo da Silva Maia (6,*) orcid

(1) Núcleo de Desenvolvimento de Compostos Bioativos, Universidade Federal do Triângulo Mineiro, Uberaba-MG, 38064-200, Brazil
(2) Instituto de Química, Universidade de São Paulo, São Paulo-SP, 13560-970, Brazil
(3) Instituto de Química, Universidade de São Paulo, São Paulo-SP, 13560-970, Brazil
(4) Núcleo de Desenvolvimento de Compostos Bioativos, Universidade Federal do Triângulo Mineiro, Uberaba-MG, 38064-200, Brazil
(5) Núcleo de Desenvolvimento de Compostos Bioativos, Universidade Federal do Triângulo Mineiro, Uberaba-MG, 38064-200, Brazil
(6) Núcleo de Desenvolvimento de Compostos Bioativos, Universidade Federal do Triângulo Mineiro, Uberaba-MG, 38064-200, Brazil
(*) Corresponding Author

Received: 31 Jan 2021 | Revised: 26 Mar 2021 | Accepted: 02 Apr 2021 | Published: 30 Sep 2021 | Issue Date: September 2021

Abstract


The reaction between 5-nitroisatin with S-benzyl dithiocarbazate affords a new isatindithio carbazate so-called NO2Isadtc (Benzyl 2-(5-nitro-2-oxoindolin-3-ylidene)hydrazinecarbodi thioate) which was characterized by means of 1H NMR, FT-IR, UV-visible and single crystal X-ray diffraction - Crystal data for C16H12N4O3S2 (M =372.42 g/mol): triclinic space group P-1, (n°. 02), a = 6.640 Å, b = 8.256 Å, c = 15.908 Å, V = 849.6 Å3, Z = 2, T = 293 K, μ(MoKα) = 0.337 mm-1, Dcalc = 1.456 g/cm3, 27515 reflections measured (2.499° ≤ 2Θ ≤ 26.524°), 3518 unique (Rint = 0.0533, Rsigma =0.0222) which were used in all calculations. The final R1 was 0.0367 (I > 2σ(I)) and wR2 was 0.1045 (all data). Computational methods were applied to NO2Isadtc and its nonsubstituted parent compound Isadtc for structure optimization, electronic distribution, and infrared calculations using B3LYP functional with 6-31G(d,p) basis set in ethanol as a polarizable continuum model. Furthermore, docking studies using human thioredoxin reductase 1 (TrxR) as enzyme target also were performed using NO2Isadtc and the optimized structure of Isadtc. The results demonstrated that both NO2Isadtc and Isadtc may act as inhibitors of TrxR, having different interactions detected, highlighting the contact between the NO2 group and the S111 at the helix which is found for NO2Isadtc.


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Editor-in-Chief
European Journal of Chemistry

Keywords


DFT; Isatins; Dithiocarbazates; Antitumor agents; Molecular docking; Thioredoxin reductase

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DOI: 10.5155/eurjchem.12.3.235-241.2106

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Funding information


CNDCT (Grants: 438316/ 2018-5, 309145/2020-1, 424095/2018-1, 307443/2015-9, 307836/2018-5 and 140219/2020-0), FAPSP (Grant 2009/54011-8) and FAPEMG (Grants: APQ-00941-14, APQ-03174-18, APQ-01988-14, APQ-00583-13 and APQ-03017-16).

Citations

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[1]. Mohd Abdul Fatah Abdul Manan, David B. Cordes, Aidan P. McKay, Mohd Fazli Mohammat, Mohd Fadhlizil Fasihi Mohd Aluwi, Nor Saliyana Jumali
(Z)-Benzyl 2-(5-methyl-2-oxoindolin-3-ylidene)hydrazinecarbodithioate
IUCrData  8(9), , 2023
DOI: 10.1107/S2414314623007824
/

References


[1]. Silva, B. N. M. da; Bastos, R. S.; Silva, B. V.; Pinto, A. C. Quim. Nova 2010, 33, 2279-2282.
https://doi.org/10.1590/S0100-40422010001000043

[2]. Chiyanzu, I.; Hansell, E.; Gut, J.; Rosenthal, P. J.; McKerrow, J. H.; Chibale, K. Bioorg. Med. Chem. Lett. 2003, 13, 3527-3530.
https://doi.org/10.1016/S0960-894X(03)00756-X

[3]. Manan, M. A. F. A.; Crouse, K. A.; Tahir, M. I. M.; Rosli, R.; How, F. N.-F.; Watkin, D. J.; Slawin, A. M. Z. J. Chem. Crystallogr. 2011, 41, 1630-1641.
https://doi.org/10.1007/s10870-011-0151-2

[4]. El-Sawi, E. A.; Mostafa, T. B.; Radwan, H. A. Eur. J. Chem. 2011, 2, 539-543.
https://doi.org/10.5155/eurjchem.2.4.539-543.55

[5]. Singh, V. P.; Singh, S.; Singh, D. P. J. Enzyme Inhib. Med. Chem. 2012, 27, 319-329.
https://doi.org/10.3109/14756366.2011.588228

[6]. Pavan, F. R.; da S Maia, P. I.; Leite, S. R. A.; Deflon, V. M.; Batista, A. A.; Sato, D. N.; Franzblau, S. G.; Leite, C. Q. F. Eur. J. Med. Chem. 2010, 45, 1898-1905.
https://doi.org/10.1016/j.ejmech.2010.01.028

[7]. Singh, R.; Kaushik, N. K. Main Group Met. Chem. 2004, 27 (6), 327-334.
https://doi.org/10.1515/MGMC.2004.27.6.327

[8]. Yekke-ghasemi, Z.; Takjoo, R.; Ramezani, M.; Mague, J. T. RSC Adv. 2018, 8, 41795-41809.
https://doi.org/10.1039/C8RA07100D

[9]. Ramilo-Gomes, F.; Addis, Y.; Tekamo, I.; Cavaco, I.; Campos, D. L.; Pavan, F. R.; Gomes, C. S. B.; Brito, V.; Santos, A. O.; Domingues, F.; Luís, Â.; Marques, M. M.; Pessoa, J. C.; Ferreira, S.; Silvestre, S.; Correia, I. J. Inorg. Biochem. 2021, 216, 111331.
https://doi.org/10.1016/j.jinorgbio.2020.111331

[10]. Yekke-ghasemi, Z.; Ramezani, M.; Mague, J. T.; Takjoo, R. New J. Chem. 2020, 44, 8878-8889.
https://doi.org/10.1039/D0NJ01187H

[11]. Fritz-Wolf, K.; Urig, S.; Becker, K. J. Mol. Biol. 2007, 370, 116-127.
https://doi.org/10.1016/j.jmb.2007.04.044

[12]. Maia, P. I. da S.; Fernandes, A. G. de A.; Silva, J. J. N.; Andricopulo, A. D.; Lemos, S. S.; Lang, E. S.; Abram, U.; Deflon, V. M. J. Inorg. Biochem. 2010, 104, 1276-1282.
https://doi.org/10.1016/j.jinorgbio.2010.08.009

[13]. Altomare, A.; Cascarano, G.; Giacovazzo, C.; Guagliardi, A.; Burla, M. C.; Polidori, G.; Camalli, M. J. Appl. Crystallogr. 1994, 27, 435-435.
https://doi.org/10.1107/S002188989400021X

[14]. Sheldrick, G. M. Acta Crystallogr. A 2008, 64, 112-122.
https://doi.org/10.1107/S0108767307043930

[15]. Abu El-Reash, G. M.; Taha, F.; Shallaby, A. M.; El-Gamal, O. A. Indian J. Chem., Sect. A: Inorg., Phys., Theor. Anal. 1991, 30 (3), 286-289. http://nopr.niscair.res.in/handle/123456789/41831 (accessed April 6, 2021).

[16]. Ali, M. A.; Mirza, A. H.; Bakar, H. J. H. A.; Bernhardt, P. V. Polyhedron 2011, 30, 556-564.
https://doi.org/10.1016/j.poly.2010.11.016

[17]. Xia, J.-J. J. Struct. Chem. 2014, 55, 130-133.
https://doi.org/10.1134/S0022476614010211

[18]. Frisch, M. J.; Trucks G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, J. L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Montgomery, J. A.; Peralta, J. E.; Ogliaro, F.; Bearpark, M.; Heyd, J. J.; Brothers, E.; Kudin, K. N.; Staroverov, V. N.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Rega, N.; Millam, J. M.; Klene, M.; Knox, J. E.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; A. J. Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Zakrzewski, V. G; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Dapprich, S.; Daniels, A. D.; Farkas, O.; Foresman, J. B.; Ortiz, J. V.; Cioslowski, J.; Fox, D. J. Gaussian, Inc. , Gaussian 09, Revision D.01-SMP, Wallingford CT, 2013.

[19]. Jones, G.; Willett, P.; Glen, R. C.; Leach, A. R.; Taylor, R. J. Mol. Biol. 1997, 267, 727-748.
https://doi.org/10.1006/jmbi.1996.0897

[20]. Tavares, T. T.; Azevedo, G. C.; Garcia, A.; Carpanez, A. G.; Lewer, P. M.; Paschoal, D.; Müller, B. L.; Dos Santos, H. F.; Matos, R. C.; Silva, H.; Grazul, R. M.; Fontes, A. P. S. Polyhedron 2017, 132, 95-104.
https://doi.org/10.1016/j.poly.2017.05.004

[21]. Verdonk, M. L.; Cole, J. C.; Hartshorn, M. J.; Murray, C. W.; Taylor, R. D. Proteins 2003, 52, 609-623.
https://doi.org/10.1002/prot.10465

[22]. Meng, X.-Y.; Zhang, H.-X.; Mezei, M.; Cui, M. Curr. Comput. Aided Drug Des. 2011, 7, 146-157.
https://doi.org/10.2174/157340911795677602

[23]. Laskowski, R. A.; Swindells, M. B. J. Chem. Inf. Model. 2011, 51, 2778-2786.
https://doi.org/10.1021/ci200227u

[24]. Gonçalves, A. C. R.; Carneiro, Z. A.; Oliveira, C. G.; Danuello, A.; Guerra, W.; Oliveira, R. J.; Ferreira, F. B.; Veloso-Silva, L. L. W.; Batista, F. A. H.; Borges, J. C.; de Albuquerque, S.; Deflon, V. M.; Maia, P. I. S. Eur. J. Med. Chem. 2017, 141, 615-631.
https://doi.org/10.1016/j.ejmech.2017.10.013

[25]. Lacerda, R. B. M.; Freitas, T. R.; Martins, M. M.; Teixeira, T. L.; da Silva, C. V.; Candido, P. A.; Oliveira, R. J. de; Júnior, C. V.; Bolzani, V. da S.; Danuello, A.; Pivatto, M. Bioorg. Med. Chem. 2018, 26, 5816-5823.
https://doi.org/10.1016/j.bmc.2018.10.032

[26]. Lopes, C. D.; Possato, B.; Gaspari, A. P. S.; Oliveira, R. J.; Abram, U.; Almeida, J. P. A.; Rocho, F. dos R.; Leitão, A.; Montanari, C. A.; Maia, P. I. S.; da Silva, J. S.; de Albuquerque, S.; Carneiro, Z. A. ACS Infect. Dis. 2019, 5, 1698-1707.
https://doi.org/10.1021/acsinfecdis.8b00284

[27]. Sousa, L. M.; Souza, W. A.; Paixão, D. A.; Fazzi, R. B.; Tezuka, D. Y.; Lopes, C. D.; Carneiro, Z. A.; Moreira, M. B.; Pivatto, M.; Netto, A. V. G.; de Albuquerque, S.; Ferreira, F. B.; De Oliveira, R. J.; Resende, J. A. L. C.; Lino, R. C.; De Oliveira Júnior, R. J.; Da Costa Ferreira, A. M.; Guerra, W. Inorg. Chim. Acta 2020, 511, 119824.
https://doi.org/10.1016/j.ica.2020.119824

[28]. Farrugia, L. J. J. Appl. Crystallogr. 1997, 30, 565-565.
https://doi.org/10.1107/S0021889897003117

[29]. Carneiro, Z. A.; Lima, J. C.; Lopes, C. D.; Gaspari, A. P. S.; de Albuquerque, S.; Dinelli, L. R.; Veloso-Silva, L. L. W.; Paganelli, M. O.; Libardi, S. H.; Oliveira, C. G.; Deflon, V. M.; Oliveira, R. J.; Borges, J. C.; Maia, P. I. S. Eur. J. Med. Chem. 2019, 180, 213-223.
https://doi.org/10.1016/j.ejmech.2019.07.014

[30]. Ilari, A.; Baiocco, P.; Messori, L.; Fiorillo, A.; Boffi, A.; Gramiccia, M.; Di Muccio, T.; Colotti, G. Amino Acids 2012, 42, 803-811.
https://doi.org/10.1007/s00726-011-0997-9

[31]. Messori, L.; Scaletti, F.; Massai, L.; Cinellu, M. A.; Gabbiani, C.; Vergara, A.; Merlino, A. Chem. Commun. (Camb.) 2013, 49, 10100-10102.
https://doi.org/10.1039/c3cc46400h


Supporting information


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How to cite


Pereira, P.; Lima, J.; Deflon, V.; Malpass, G.; de Oliveira, R.; Maia, P. Eur. J. Chem. 2021, 12(3), 235-241. doi:10.5155/eurjchem.12.3.235-241.2106
Pereira, P.; Lima, J.; Deflon, V.; Malpass, G.; de Oliveira, R.; Maia, P. Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies. Eur. J. Chem. 2021, 12(3), 235-241. doi:10.5155/eurjchem.12.3.235-241.2106
Pereira, P., Lima, J., Deflon, V., Malpass, G., de Oliveira, R., & Maia, P. (2021). Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies. European Journal of Chemistry, 12(3), 235-241. doi:10.5155/eurjchem.12.3.235-241.2106
Pereira, Pedro, Jackelinne Camargo Lima, Victor Marcelo Deflon, Geoffroy Roger Pointer Malpass, Ronaldo Junio de Oliveira, & Pedro Ivo da Silva Maia. "Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies." European Journal of Chemistry [Online], 12.3 (2021): 235-241. Web. 10 Dec. 2023
Pereira, Pedro, Lima, Jackelinne, Deflon, Victor, Malpass, Geoffroy, de Oliveira, Ronaldo, AND Maia, Pedro Ivo. "Nitroisatin dithiocarbazate: Synthesis, structural characterization, DFT, and docking studies" European Journal of Chemistry [Online], Volume 12 Number 3 (30 September 2021)

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