European Journal of Chemistry 2021, 12(3), 279-283 | doi: https://doi.org/10.5155/eurjchem.12.3.279-283.2118 | Get rights and content

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Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent


Gautam Sadawarte (1) orcid , Samadhan Jagatap (2) orcid , Mukesh Patil (3) orcid , Vasant Jagrut (4) orcid , Jamatsing Darbarsing Rajput (5,*) orcid

(1) Department of Chemistry, Faculty of B.P. Arts, S.M.A. Science and K.K.C. Commerce College Chalisgaon, Maharashtra, 424101, India
(2) Department of Chemistry, Faculty of B.P. Arts, S.M.A. Science and K.K.C. Commerce College Chalisgaon, Maharashtra, 424101, India
(3) Department of Zoology, Faculty of B.P. Arts, S.M.A. Science and K.K.C. Commerce College, Chalisgaon Maharashtra, 424101, India
(4) Department of Chemistry, Swami Vivekanand College, Mantha Jalna, 431504 India
(5) Department of Chemistry, Faculty of B.P. Arts, S.M.A. Science and K.K.C. Commerce College Chalisgaon, Maharashtra, 424101, India
(*) Corresponding Author

Received: 07 Apr 2021 | Revised: 11 Jun 2021 | Accepted: 15 Jul 2021 | Published: 30 Sep 2021 | Issue Date: September 2021

Abstract


This research work describes the synthesis of a new series of heterocyclic compounds, namely sulfonamide derivatives. Sulfonamides are a diverse class of organic compounds having significant and potent biological activities. Diverse synthetic methods have been engaged to build up its various derivatives for different biological functions. In this study, the production of novel pyridine-based heterocyclic compounds having sulfonamide moieties has been elaborated. The obtained sulfonamide-based pyridine scaffold was used to investigate their alpha-amylase inhibition activity. The structures of freshly prepared compounds were described using 1H NMR, 13C NMR, and IR spectroscopic techniques. The molecular docking of sulfonamides performed against porcine pancreatic alpha-amylase using PDB file 1LP was used for generation of grid. All the new synthesized compounds were shown notable anti-diabetic activity.


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Editor-in-Chief
European Journal of Chemistry

Keywords


Acarbose; Sulfonamides; Alpha-amylase; Antidiabetic activity; Medicinal chemistry; N-Isopropyl-4-methylpyridine-2,6-diamine

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DOI: 10.5155/eurjchem.12.3.279-283.2118

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Citations

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[1]. Gautam P. Sadawarte, Nilesh K. Halikar, Amol D. Kale, Vasant B. Jagrut
Sodium Oxalate Mediate Synthesis and α-Amalyase Inhibition Assay of 5-Substituted-3-Phenyl-2-Thioxoimidazolidin-4-Ones
Polycyclic Aromatic Compounds  , 1, 2023
DOI: 10.1080/10406638.2023.2177681
/


[2]. Aprajita Matthew, Rajnish Kumar, Avijit Mazumder, Salahuddin, Harshita Bhadauria
Insights Into the Synthetic Strategies, Biological Activity, and Structure- Activity Relationship of Pyridine and Analogs: A Review
Letters in Organic Chemistry  20(11), 1025, 2023
DOI: 10.2174/1570178620666230525142927
/


[3]. Sourav De, Ashok Kumar S K, Suraj Kumar Shah, Sabnaz Kazi, Nandan Sarkar, Subhasis Banerjee, Sanjay Dey
Pyridine: the scaffolds with significant clinical diversity
RSC Advances  12(24), 15385, 2022
DOI: 10.1039/D2RA01571D
/


[4]. Redouane Achagar, Abdelhakim Elmakssoudi, Abderrahmane Thoume, Mohamed Dakir, Abdelaziz Elamrani, Yassine Zouheir, Mohamed Zahouily, Zouhair Ait-Touchente, Jamal Jamaleddine, Mohamed M. Chehimi
Nanostructured Na2CaP2O7: A New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity
Applied Sciences  12(11), 5487, 2022
DOI: 10.3390/app12115487
/


[5]. Christiana Abimbola Salubi, Vijay Kumar Siripuram
Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety
Journal of Chemistry  2023, 1, 2023
DOI: 10.1155/2023/3601764
/


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How to cite


Sadawarte, G.; Jagatap, S.; Patil, M.; Jagrut, V.; Rajput, J. Eur. J. Chem. 2021, 12(3), 279-283. doi:10.5155/eurjchem.12.3.279-283.2118
Sadawarte, G.; Jagatap, S.; Patil, M.; Jagrut, V.; Rajput, J. Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent. Eur. J. Chem. 2021, 12(3), 279-283. doi:10.5155/eurjchem.12.3.279-283.2118
Sadawarte, G., Jagatap, S., Patil, M., Jagrut, V., & Rajput, J. (2021). Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent. European Journal of Chemistry, 12(3), 279-283. doi:10.5155/eurjchem.12.3.279-283.2118
Sadawarte, Gautam, Samadhan Jagatap, Mukesh Patil, Vasant Jagrut, & Jamatsing Darbarsing Rajput. "Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent." European Journal of Chemistry [Online], 12.3 (2021): 279-283. Web. 10 Dec. 2023
Sadawarte, Gautam, Jagatap, Samadhan, Patil, Mukesh, Jagrut, Vasant, AND Rajput, Jamatsing. "Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent" European Journal of Chemistry [Online], Volume 12 Number 3 (30 September 2021)

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