European Journal of Chemistry 2011, 2(3), 394-403 | doi: | Get rights and content

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Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide

Linganna Shiva Kumar (1) , Kollur Shiva Prasad (2) , Hosakere Doddarevanna Revanasiddappa (3,*)

(1) Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
(2) Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
(3) Department of Chemistry, University of Mysore, Manasagangotri, Mysore-570006, Karnataka, India
(*) Corresponding Author

Received: 06 Aug 2010 | Revised: 30 Nov 2010 | Accepted: 17 Feb 2011 | Published: 30 Sep 2011 | Issue Date: September 2011


In this report, we explore the DNA binding properties of mixed ligand copper(II)/cobalt(II) complexes of the type [M(bnp)(phen)H2O].nH2O, and copper(II)/cobalt(II) complexes of the type [M(Hbnp)2], where n=0, 1, ..., H2bnp=3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphtho-hydrazide and phen=1,10-phenanthroline. A host of physical methods like spectral absorption, emission studies and hydrodynamic measurements have been used to probe the effect of ligands on the mode and extent of interaction of the complexes with Calf Thymus DNA. The efficiencies of the complexes to oxidatively cleaved pUC19 DNA was performed in the absence and presence of H2O2. Among the compounds tested for antioxidant capacity, H2bnp displayed excellent activity than its complexes and standards used. It has been observed that Cu(II) and Co(II) complexes exhibited different levels of antibacterial and antifungal effects, with the assays carried out on four pathogenic bacteria and two pathogenic fungi. H2bnp showed moderate activity against bacteria E. coli, X. vesicatoria and fungi, A. niger and A. flavus, but less than its complexes and standard drugs used for assay.



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European Journal of Chemistry


Naphthohydrazide; Metal complexes; DNA binding; Oxidative cleavage; Antioxidant; Antimicrobial activity

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DOI: 10.5155/eurjchem.2.3.394-403.232

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University Grants Commission, University of Mysore, Mysore, Karnataka, India



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How to cite

Kumar, L.; Prasad, K.; Revanasiddappa, H. Eur. J. Chem. 2011, 2(3), 394-403. doi:10.5155/eurjchem.2.3.394-403.232
Kumar, L.; Prasad, K.; Revanasiddappa, H. Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide. Eur. J. Chem. 2011, 2(3), 394-403. doi:10.5155/eurjchem.2.3.394-403.232
Kumar, L., Prasad, K., & Revanasiddappa, H. (2011). Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide. European Journal of Chemistry, 2(3), 394-403. doi:10.5155/eurjchem.2.3.394-403.232
Kumar, Linganna, Kollur Shiva Prasad, & Hosakere Doddarevanna Revanasiddappa. "Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide." European Journal of Chemistry [Online], 2.3 (2011): 394-403. Web. 28 Sep. 2023
Kumar, Linganna, Prasad, Kollur, AND Revanasiddappa, Hosakere. "Synthesis, characterization, antioxidant, antimicrobial, DNA binding and cleavage studies of mononuclear Cu(II) and Co(II) complexes of 3-hydroxy-N'-(2-hydroxybenzylidene)-2-naphthohydrazide" European Journal of Chemistry [Online], Volume 2 Number 3 (30 September 2011)

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