European Journal of Chemistry 2022, 13(4), 478-482 | doi: https://doi.org/10.5155/eurjchem.13.4.478-482.2352 | Get rights and content

Issue cover




Crossmark

  Open Access OPEN ACCESS | Open Access PEER-REVIEWED | RESEARCH ARTICLE | DOWNLOAD PDF | VIEW FULL-TEXT PDF | TOTAL VIEWS

Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire


Sylla Tahiri (1,*) orcid , M’bra Kouassi Fulgence (2) orcid , Dongui Bini Kouame (3) orcid

(1) Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
(2) Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
(3) Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire
(*) Corresponding Author

Received: 27 Sep 2022 | Revised: 14 Oct 2022 | Accepted: 28 Oct 2022 | Published: 31 Dec 2022 | Issue Date: December 2022

Abstract


The phytochemical, antioxidant, and anti-inflammatory potential of root (ethanol and aqueous) extracts of Combretum glutinosum was investigated in this study. Their antioxidant activity was determined using an in vitro DPPH radical scavenging activity assay. The ethanol extract had the lowest IC50 (0.055 mg/mL), which is comparable to vitamin C. Phytochemical screening of extracts revealed the presence of sterols and polyterpenes, polyphenols, alkaloids, flavonoids, catechin tannins, gallic tannins, saponosides, terpenoids, mucilages, anthocyanins, volatile oils, and cardiac glycosides. The extracts significantly inhibit the development of paw edema induced by carrageenan. Anti-inflammatory studies showed that the inflammation inhibition potential of 200 mg/kg body weight of all extracts was significantly lower than the standard diclofenac (20 mg/kg) in the first hours. At the third hour, the inflammation inhibition potential of ethanolic and aqueous extracts was significantly higher than that of the standard. This study revealed that Combretum glutinosum extracts have anti-inflammatory effects and can act as an effective antioxidant.


Announcements


One of our sponsors will cover the article processing fee for all submissions made between May 17, 2023 and May 31, 2023 (Voucher code: SPONSOR2023).

Editor-in-Chief
European Journal of Chemistry

Keywords


Paw edema; Antioxidant; DPPH radical; Phytochemical; Anti-inflammatory; Combretum glutinosum

Full Text:

PDF
PDF    Open Access

DOI: 10.5155/eurjchem.13.4.478-482.2352

Links for Article


| | | | | | |

| | | | | | |

| | | |

Related Articles




Article Metrics

icon graph This Abstract was viewed 233 times | icon graph PDF Article downloaded 49 times

Funding information


Laboratory of Environmental Sciences and Technologies, UFR Environment, Jean Lorougnon Guede University, BP 150 Daloa, Côte d'Ivoire.

Citations

/


[1]. Yevgeniya Shatalova, Tolkyn Zakupova, Frants Galitskiy, Mete Korkut Gülmen, Kenan Kaya, Tuğçe Koca Yavuz
Analysis of the Pregnancy Outcome in Severe Injury in Pregnant Women According to Forensic Examinations for 2008-2017 in Astana
The Bulletin of Legal Medicine  28(1), 41, 2023
DOI: 10.17986/blm.1620
/


[2]. Ananya Bahuguna, Shiv Kumar Dubey, Vaishali Garia, Ravendra Kumar, Om Prakash, Dharmendra Singh Rawat
Composition, antioxidant and anti-inflammatory activities of different polarity extracts of Anaphalis busua from the Himalayan terrain of Uttarakhand
European Journal of Chemistry  14(1), 114, 2023
DOI: 10.5155/eurjchem.14.1.114-120.2395
/


References


[1]. Cirak, C.; Radusiene, J.; Raudone, L.; Vilkickyte, G.; Seyis, F.; Marksa, M.; Ivanauskas, L.; Yayla, F. Phenolic compounds and antioxidant activity of Achillea arabica populations. S. Afr. J. Bot. 2022, 147, 425-433.
https://doi.org/10.1016/j.sajb.2022.02.006

[2]. Liu, Z.-Q. Why natural antioxidants are readily recognized by biological systems? 3D architecture plays a role! Food Chem. 2022, 380, 132143.
https://doi.org/10.1016/j.foodchem.2022.132143

[3]. Luna, E. M.; Lopes, H. T. O.; Rodrigues, F. A. Á.; Coutinho, H. D. M.; de Oliveira, L. C. C. Antioxidant potential of the Caatinga flora. Phytomedicine Plus 2022, 2, 100240.
https://doi.org/10.1016/j.phyplu.2022.100240

[4]. Francis, P.; Chakraborty, K. An anti-inflammatory salmachroman from the sea urchin Salmacis bicolor: a prospective duel inhibitor of cyclooxygenase-2 and 5-lipoxygenase. Nat. Prod. Res. 2021, 35, 5102-5111.
https://doi.org/10.1080/14786419.2020.1781115

[5]. Truong, V.-L.; Jeong, W.-S. Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases. Food Sci. Hum. Wellness 2022, 11, 502-511.
https://doi.org/10.1016/j.fshw.2021.12.008

[6]. Urumbil, S. K.; Anilkumar, M. N. Anti-inflammatory activity of endophytic bacterial isolates from Emilia sonchifolia (Linn.) DC. J. Ethnopharmacol. 2021, 281, 114517.
https://doi.org/10.1016/j.jep.2021.114517

[7]. Dimobe, K.; Mensah, S.; Goetze, D.; Ouédraogo, A.; Kuyah, S.; Porembski, S.; Thiombiano, A. Aboveground biomass partitioning and additive models for Combretum glutinosum and Terminalia laxiflora in West Africa. Biomass Bioenergy 2018, 115, 151-159.
https://doi.org/10.1016/j.biombioe.2018.04.022

[8]. Madièye, S.; Firmin, S. B.; Abdou, S.; Alioune, D. F.; Yacine, N.; Guata, Y. S. Y. Healing and topical anti-inflammatory activities of the total aqueous bark extract of Combretum glutinosum Perr. (Combretaceae). J. Med. Plant Res. 2020, 14, 215-224.
https://doi.org/10.5897/JMPR2019.6879

[9]. Alowanou, G. G.; Olounlade, A. P.; Azando, E. V. B.; Dedehou, V.; Daga, F. D.; Hounzangbe-adote, M. A review of Bridelia ferruginea, Combretum glutinosum and Mitragina inermis plants used in zoo therapeutic remedies in West Africa: historical origins, current uses and implications for conservation. J. Appl. Biosci. 2015, 87, 8003-8014.
https://doi.org/10.4314/jab.v87i1.4

[10]. Rana, A.; Bhakuni Negi, P.; Gopal Sahoo, N. Phytochemical screening and characterization of bioactive compounds from Juniperus squamata root extract. Mater. Today 2022, 48, 672-675.
https://doi.org/10.1016/j.matpr.2021.07.305

[11]. Alqethami, A.; Aldhebiani, A. Y. Medicinal plants used in Jeddah, Saudi Arabia: Phytochemical screening. Saudi J. Biol. Sci. 2021, 28, 805-812.
https://doi.org/10.1016/j.sjbs.2020.11.013

[12]. Lanuza, J.; Postils, V.; Lopez, X. Can aluminum, a non-redox metal, alter the thermodynamics of key biological redox processes? The DPPH-QH2 radical scavenging reaction as a test case. Free Radic. Biol. Med. 2022, 179, 200-207.
https://doi.org/10.1016/j.freeradbiomed.2021.12.308

[13]. Chen, X.; Liang, L.; Han, C. Borate suppresses the scavenging activity of gallic acid and plant polyphenol extracts on DPPH radical: A potential interference to DPPH assay. Lebenson. Wiss. Technol. 2020, 131, 109769.
https://doi.org/10.1016/j.lwt.2020.109769

[14]. Pierre Luhata, L.; Usuki, T. Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae). Bioorg. Med. Chem. Lett. 2022, 59, 128528.
https://doi.org/10.1016/j.bmcl.2022.128528

[15]. Chakraborty, K.; Francis, P. Hyrtioscalaranes A and B, two new scalarane-type sesterterpenes from Hyrtios erectus with anti-inflammatory and antioxidant effects. Nat. Prod. Res. 2021, 35, 5559-5570.
https://doi.org/10.1080/14786419.2020.1795854

[16]. Chen, J.-T.; Ostermann, M. Review of anti-inflammatory and antiviral therapeutics for hospitalized patients infected with severe acute respiratory syndrome Coronavirus 2. Crit. Care Clin. 2022, 38, 587-600.
https://doi.org/10.1016/j.ccc.2022.02.002

[17]. Nikkheslat, N. Targeting inflammation in depression: Ketamine as an anti-inflammatory antidepressant in psychiatric emergency. Brain Behav Immun Health 2021, 18, 100383.
https://doi.org/10.1016/j.bbih.2021.100383

[18]. Bailly, C. Medicinal properties and anti-inflammatory components of Phytolacca (Shanglu). Digital Chinese Medicine 2021, 4, 159-169.
https://doi.org/10.1016/j.dcmed.2021.09.001

[19]. Adem, S. R.; Ayangbenro, A. S.; Gopane, R. E. Phytochemical screening and antimicrobial activity of Olea europaea subsp. africana against pathogenic microorganisms. Scientific African 2020, 10, e00548.
https://doi.org/10.1016/j.sciaf.2020.e00548

[20]. Ahmed, H. M. Phytochemical screening, total phenolic content and phytotoxic activity of corn (Zea mays) extracts against some indicator species. Nat. Prod. Res. 2018, 32, 714-718.
https://doi.org/10.1080/14786419.2017.1333992


How to cite


Tahiri, S.; Fulgence, M.; Kouame, D. Eur. J. Chem. 2022, 13(4), 478-482. doi:10.5155/eurjchem.13.4.478-482.2352
Tahiri, S.; Fulgence, M.; Kouame, D. Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire. Eur. J. Chem. 2022, 13(4), 478-482. doi:10.5155/eurjchem.13.4.478-482.2352
Tahiri, S., Fulgence, M., & Kouame, D. (2022). Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire. European Journal of Chemistry, 13(4), 478-482. doi:10.5155/eurjchem.13.4.478-482.2352
Tahiri, Sylla, M’bra Kouassi Fulgence, & Dongui Bini Kouame. "Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire." European Journal of Chemistry [Online], 13.4 (2022): 478-482. Web. 28 May. 2023
Tahiri, Sylla, Fulgence, M’bra, AND Kouame, Dongui. "Phytochemical analysis, investigation of antioxidant and anti-inflammatory activities of ethanolic and aqueous extracts of roots of Combretum glutinosum Perr. ex DC from Cote d'Ivoire" European Journal of Chemistry [Online], Volume 13 Number 4 (31 December 2022)

The other citation formats (EndNote | Reference Manager | ProCite | BibTeX | RefWorks) for this article can be found online at: How to cite item



DOI Link: https://doi.org/10.5155/eurjchem.13.4.478-482.2352


CrossRef | Scilit | GrowKudos | Researchgate | Publons | ScienceGate | Scite | Lens | OUCI

WorldCat Paperbuzz | LibKey Citeas | Dimensions | Semanticscholar | Plumx | Kopernio | Zotero | Mendeley

ZoteroSave to Zotero MendeleySave to Mendeley



European Journal of Chemistry 2022, 13(4), 478-482 | doi: https://doi.org/10.5155/eurjchem.13.4.478-482.2352 | Get rights and content

Refbacks

  • There are currently no refbacks.




Copyright (c) 2022 Authors

Creative Commons License
This work is published and licensed by Atlanta Publishing House LLC, Atlanta, GA, USA. The full terms of this license are available at http://www.eurjchem.com/index.php/eurjchem/pages/view/terms and incorporate the Creative Commons Attribution-Non Commercial (CC BY NC) (International, v4.0) License (http://creativecommons.org/licenses/by-nc/4.0). By accessing the work, you hereby accept the Terms. This is an open access article distributed under the terms and conditions of the CC BY NC License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited without any further permission from Atlanta Publishing House LLC (European Journal of Chemistry). No use, distribution or reproduction is permitted which does not comply with these terms. Permissions for commercial use of this work beyond the scope of the License (http://www.eurjchem.com/index.php/eurjchem/pages/view/terms) are administered by Atlanta Publishing House LLC (European Journal of Chemistry).



© Copyright 2010 - 2023  Atlanta Publishing House LLC All Right Reserved.

The opinions expressed in all articles published in European Journal of Chemistry are those of the specific author(s), and do not necessarily reflect the views of Atlanta Publishing House LLC, or European Journal of Chemistry, or any of its employees.

Copyright 2010-2023 Atlanta Publishing House LLC. All rights reserved. This site is owned and operated by Atlanta Publishing House LLC whose registered office is 2850 Smith Ridge Trce Peachtree Cor GA 30071-2636, USA. Registered in USA.